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Author Details

Kathy K Niakan
The Francis Crick Institute
2000
47
28
PMIDPaper TitleJournal TitlePublished Year
37295962Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1.Hum Reprod2023
38012405Author Correction: Changing the public perception of human embryology.Nat Cell Biol2023
37619506Human embryo models: the importance of national policy and governance review.Curr Opin Genet Dev2023
37985870Changing the public perception of human embryology.Nat Cell Biol2023
37879938MICA: a multi-omics method to predict gene regulatory networks in early human embryos.Life Sci Alliance2023
36971487A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals.Development2023
35502739GIANI - open-source software for automated analysis of 3D microscopy images.J Cell Sci2022
33239783TRF2-independent chromosome end protection during pluripotency.Nature2021
34432381Generating CRISPR-Cas9-Mediated Null Mutations and Screening Targeting Efficiency in Human Pluripotent Stem Cells.Curr Protoc2021
34463252TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells.Elife2021
34050011Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos.Proc Natl Acad Sci U S A2021
34048692ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.Stem Cell Reports2021
34048690Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines.Stem Cell Reports2021
32451402The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.Nat Commun2020
31778245Effects of thyroid hormone on mitochondria and metabolism of human preimplantation embryos.Stem Cells2020
31822824Author Correction: Human germline genome editing.Nat Cell Biol2020
32034154IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche.Nat Commun2020
32968278Initiation of a conserved trophectoderm program in human, cow and mouse embryos.Nature2020
33021826Human Embryogenesis: A Comparative Perspective.Annu Rev Cell Dev Biol2020
29477167Human Pre-gastrulation Development.Curr Top Dev Biol2018
30393076SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.Dev Cell2018
28976971Erratum: Genome editing reveals a role for OCT4 in human embryogenesis.Nature2017
28087629Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.Development2017
29107595Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development.Stem Cell Reports2017
28953884Genome editing reveals a role for OCT4 in human embryogenesis.Nature2017
27281217Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.Nature2016
27144686Self-organization of the human embryo in the absence of maternal tissues.Nat Cell Biol2016
27462813Corrigendum: Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.Nature2016
26109048Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells.Genes Dev2015
26487783Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.Development2015
26293300Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.Development2015
26059426Dynamic Proteomic Profiling of Extra-Embryonic Endoderm Differentiation in Mouse Embryonic Stem Cells.Stem Cells2015
23261930Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse.Dev Biol2013
23640167Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells.Nat Protoc2013
22318624Human pre-implantation embryo development.Development2012
22802932Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.PLoS One2012
22791892Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states.Development2012
21816365BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.Cell Stem Cell2011
20123909Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.Genes Dev2010
19200798Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines.Cell Stem Cell2009
18669821Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.Science2008
16466956Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis.Mol Genet Metab2006
16146703DAX1 origin, function, and novel role.Mol Genet Metab2005
14678822Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis.Gene Expr Patterns2004
15300857IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1.Hum Mutat2004
12200364X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.Blood2002
10733494Mapping of a syndrome of X-linked thrombocytopenia with Thalassemia to band Xp11-12: further evidence of genetic heterogeneity of X-linked thrombocytopenia.Blood2000
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Collaborators

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Stanford University
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Exercise Medicine Research Institute, Edith Cowan University
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Newcastle University
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UK Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge
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Carlsberg Laboratory, Case Western Reserve University, Johns Hopkins Medicine, Johns Hopkins School of Medicine, Johns Hopkins School of Public Health, Johns Hopkins University, National Academy of Sciences, Pennsylvania State University, Presidential Commission for the Study of Bioethical Issues
Co-authored papers 2
The Hospital for Sick Children
Co-authored papers 2
College of life sciences, Jiangxi Normal university
Co-authored papers 2
University of Washington School of Medicine
Co-authored papers 2
University of Washington
Co-authored papers 2
College of Life Sciences
Co-authored papers 2
The Gurdon Institute
Co-authored papers 2
University of Washington
Co-authored papers 2
Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University
Co-authored papers 2
Harvard University, Howard Hughes Medical Institute, Harvard Stem Cell Institute
Co-authored papers 2
Osaka University
Co-authored papers 2
the Rockefeller University
Co-authored papers 2
Center for Reproductive Science, University of California los angeles
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California Institute of Technology, USA. institute of technology.edu.
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Department of Medical Ethics and Law, Peking University Health Science Center
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Advanced Research Institute, Tokyo Medical and Dental University
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Catalan Institution for Research and Advanced Studies (ICREA)
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Johns Hopkins University, Berman Institute of Bioethics
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Boston Children's Hospital, Harvard Medical School
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