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Author Details

Joseph F Costello
University of California san francisco
1991
157
63
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37645893Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections.bioRxiv2024
36239925Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions.Neuro Oncol2023
38079020"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.Acta Neuropathol2023
37436963Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.Neuro Oncol2023
36997627Hyperpolarized δ-[1- <sup>13</sup>C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma.Sci Rep2023
36856115Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects.J Clin Invest2023
35325218TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo.Neuro Oncol2022
35679032Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.Clin Cancer Res2022
35534562Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.Nat Genet2022
35460557Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma.Neuro Oncol2022
36130485GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.Cell Rep2022
35945463Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.Acta Neuropathol2022
36114166Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer.Nat Commun2022
35287169PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications.Neuro Oncol2022
33130899Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors.Neuro Oncol2021
33823014Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas.Neuro Oncol2021
33758101miRNA-independent function of long noncoding pri-miRNA loci.Proc Natl Acad Sci U S A2021
33758097Cancer-specific loss of <i>TERT</i> activation sensitizes glioblastoma to DNA damage.Proc Natl Acad Sci U S A2021
33668509Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma.Metabolites2021
33864084Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas.Neuro Oncol2021
33891899Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease.Dev Cell2021
34671124Publisher Correction: Epigenomic contributions to tumor cell heterogeneity and plasticity.Nat Genet2021
34608295Epigenomic contributions to tumor cell heterogeneity and plasticity.Nat Genet2021
34049406Spatial concordance of DNA methylation classification in diffuse glioma.Neuro Oncol2021
33367885Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.Neuro Oncol2021
33397920Non-invasive assessment of telomere maintenance mechanisms in brain tumors.Nat Commun2021
32157385Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features.Acta Neuropathol2020
33264551Prostate Cancer Progression and the Epigenome.N Engl J Med2020
32968068Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.Nat Commun2020
32677466Epigenomic programming in early fetal brain development.Epigenomics2020
32904945Patient-derived cells from recurrent tumors that model the evolution of <i>IDH</i>-mutant glioma.Neurooncol Adv2020
32958546Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment.Cancer Res2020
32166314MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence.Neuro Oncol2020
30877433Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.Acta Neuropathol2019
31748746Longitudinal molecular trajectories of diffuse glioma in adults.Nature2019
30202865Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.Toxicol Sci2019
31395865Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution.Nat Commun2019
29077933Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas.Neuro Oncol2018
30154825To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes.Front Genet2018
30205050Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.Cancer Cell2018
29644006The long non-coding RNA <i>HOTAIR</i> is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma.Oncotarget2018
29452419Temozolomide-associated hypermutation in gliomas.Neuro Oncol2018
27571885Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide.Neuro Oncol2017
28450738DNA methylation: an epigenetic mark of cellular memory.Exp Mol Med2017
28289245Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution.Cold Spring Harb Perspect Med2017
28319047Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.J Clin Invest2017
29259179Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.Nat Commun2017
29308320Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma.Oncoimmunology2017
29056344Comprehensive Analysis of Hypermutation in Human Cancer.Cell2017
28916733Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant <i>IDH1</i>.Proc Natl Acad Sci U S A2017
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Collaborators

Joanna J Phillips
University of California san francisco
Co-authored papers 20
Christoph Plass
German Cancer Research Center
Co-authored papers 20
Mitchel S Berger
University of California san francisco
Co-authored papers 19
Tali Mazor
Co-authored papers 19
Marco A Marra
University of British Columbia
Co-authored papers 18
Ting Wang
Washington University School of Medicine
Co-authored papers 18
Martin Hirst
University of British Columbia
Co-authored papers 17
Annette M Molinaro
Co-authored papers 13
Jun S Song
University of Illinois at Urbana-Champaign
Co-authored papers 11
Peggy J Farnham
Keck School of Medicine of USC
Co-authored papers 11
Steven J M Jones
University of British Columbia
Co-authored papers 10
David A Solomon
University of California san francisco
Co-authored papers 10
Arie Perry
University of California san francisco
Co-authored papers 9
Bo Zhang
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Adam B Olshen
12224University of California san francisco
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Webster K Cavenee
Ludwig Institute for Cancer Research, University of California San Diego
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Nicholas Butowski
University of California san francisco
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Nancy Ann Oberheim Bush
University of California san francisco
Co-authored papers 7
Brett E Johnson
Co-authored papers 7
Michael D Prados
University of California san francisco
Co-authored papers 6
Richard A Moore
Co-authored papers 6
Angela Tam
Co-authored papers 6
Manish K Aghi
University of California san francisco
Co-authored papers 5
Michael C Frühwald
Co-authored papers 5
Scott R VandenBerg
University of California san francisco
Co-authored papers 5
Alireza Heravi-Moussavi
Ferdowsi University of Mashhad
Co-authored papers 5
Kenneth Aldape
National Cancer Institute
Co-authored papers 5
William A Weiss
University of California san francisco
Co-authored papers 5
Release 1.2