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Author Details

Stuart A Lipton
The Scripps Research Institute, University of California
1977
396
124
PMIDPaper TitleJournal TitlePublished Year
36175661Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.Nat Chem Biol2023
37797736Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression.Neuropharmacology2023
37478858S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons.Cell Chem Biol2023
37100955Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell Death Differ2023
36817649Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer's disease: Mechanistic insights and potential therapies.Front Neural Circuits2023
36739439Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.Nat Commun2023
35169022S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.J Neurosci2022
35411336Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection.bioRxiv2022
35462559S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders.Cell Death Differ2022
36516243Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3.Sci Adv2022
36314651Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.EMBO J2022
35870288Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways.Curr Opin Pharmacol2022
36243209Hidden networks of aberrant protein transnitrosylation contribute to synapse loss in Alzheimer's disease.Free Radic Biol Med2022
35052628Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome.Antioxidants (Basel)2022
32467645NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models.Mol Psychiatry2021
33876414TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use.J Neurovirol2021
33483428α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.J Neurosci2021
33692125S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.Proc Natl Acad Sci U S A2021
33833060Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.Proc Natl Acad Sci U S A2021
33942273Correction to: TCA cycle metabolic compromise due to an aberrant Sâ¿¿nitrosoproteome in HIVâ¿¿associated neurocognitive disorder with methamphetamine use.J Neurovirol2021
33957758Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders.Antioxid Redox Signal2021
34360966Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases.Int J Mol Sci2021
34115964Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.Immunity2021
34224817Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration.Free Radic Biol Med2021
33273062Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease.Science2021
32997602Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases.Annu Rev Pharmacol Toxicol2021
31657228Nitric Oxide-Dependent Protein Post-Translational Modifications Impair Mitochondrial Function and Metabolism to Contribute to Neurodegenerative Diseases.Antioxid Redox Signal2020
30611669Novel Direct Conversion of Microglia to Neurons.Trends Mol Med2019
31782729Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls.Elife2019
30928642NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.Neurobiol Dis2019
29229998Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.Cell Death Differ2018
30205056The mouse as a model for neuropsychiatric drug development.Curr Biol2018
29362479Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.Cell Death Differ2018
29523838Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease.Nat Commun2018
29483518Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.Nat Commun2018
26681768Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke.J Cereb Blood Flow Metab2017
28461502MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.Proc Natl Acad Sci U S A2017
29133852NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.Nat Commun2017
29123083Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease.Nat Commun2017
29097102'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders.Trends Endocrinol Metab2017
29166608S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.Cell Rep2017
29263788Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate.F1000Res2017
28738418Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency.Invest Ophthalmol Vis Sci2017
26118537Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation.Neurochem Res2016
26374431Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model.J Mol Neurosci2016
27821734Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons.Proc Natl Acad Sci U S A2016
27906174Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.Cell Death Dis2016
27473602S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein.J Mol Biol2016
27571160Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities.Lancet Neurol2016
27183239Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes.Neuroreport2016
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Collaborators

Tomohiro Nakamura
The Scripps Research Institute
Co-authored papers 67
Maria Talantova
The Scripps Research Institute
Co-authored papers 26
Eliezer Masliah
National Institute On Aging
Co-authored papers 22
Rajesh Ambasudhan
The Scripps Research Institute
Co-authored papers 20
Dorit Trudler
Tel Aviv University
Co-authored papers 13
Nima Dolatabadi
The Scripps Research Institute
Co-authored papers 12
John R Yates
TheScripps Research Institute
Co-authored papers 12
Swagata Ghatak
National Institute of Science Education and Research
Co-authored papers 9
Abdullah Sultan
King Abdulaziz University
Co-authored papers 7
Xuemei Han
Co-authored papers 7
Amanda J Roberts
The Scripps Research Institute
Co-authored papers 6
Adam Godzik
University of California Riverside
Co-authored papers 6
Valina L Dawson
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Co-authored papers 5
Howard E Gendelman
Co-authored papers 5
Matthew P Frosch
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 5
Rosario Rizzuto
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Piotr Cieplak
Sanford-Burnham-Prebys Medical Discovery Institute
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Jan Paul Medema
Oncode Institute
Co-authored papers 4
Michael Karin
Co-authored papers 4
Ted M Dawson
Johns Hopkins University School of Medicine
Co-authored papers 4
Mark H Ellisman
National Center for Microscopy and Imaging Research, University of California
Co-authored papers 4
David Zurakowski
Harvard Medical School, Boston Children's Hospital
Co-authored papers 4
Simone Fulda
Co-authored papers 4
Brian D Dynlacht
New York University Cancer Institute, New York University School of Medicine
Co-authored papers 4
Guang Bai
Co-authored papers 4
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 3
Jerry E Chipuk
Co-authored papers 3
Michael M Segal
PhenoSolve Inc.
Co-authored papers 3
David M Simpson
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Evan Y Snyder
Sanford Burnham Prebys Medical Discovery Institute
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Release 1.2