Author details

Full Name

Decio L Eizirik

Affiliation

ORCID

Career Start Year

1982

Papers

410

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38081640	RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures.		2024
37493471	Islet cells in human type 1 diabetes: from recent advances to novel therapies - a symposium-based roadmap for future research.		2023
36201618	Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.	Diabetes	2023
36401627	Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.	Diabetologia	2023
37949065	Stress-induced Î² cell early senescence confers protection against type 1 diabetes.		2023
37749140	Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.		2023
37745505	Interferon-Î± promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic Î²-cells.		2023
38076918	Protection of Î² cells against pro-inflammatory cytokine stress by the GDF15-ERBB2 signaling.	medRxiv	2023
37148359	The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.	Diabetologia	2023
37072614	Why does the immune system destroy pancreatic Î²-cells but not Î±-cells in type 1 diabetes?		2023
37442376	EndoC-Î²H5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion.		2023
37250773	Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning.		2023
36995380	GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.		2023
36543979	Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.		2023
36988639	Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-Î±-induced human beta cell dysfunction and death.		2023
36982731	BCL-XL Overexpression Protects Pancreatic Î²-Cells against Cytokine- and Palmitate-Induced Apoptosis.		2023
34890851	Neuropeptide Y1 receptor antagonism protects Î²-cells and improves glycemic control in type 2 diabetes.	Mol Metab	2022
36103539	Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic Î² cells.	Science advances	2022
35954309	The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.	Cells	2022
36289205	The type 1 diabetes gene TYK2 regulates Î²-cell development and its responses to interferon-Î±.	Nature Communications	2022
36287121	Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic Î² Cells.	Non-coding RNA	2022
36345338	Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic Î²-cell and brain diseases to discover therapies.	iScience	2022
35806437	The Role of Beta Cell Recovery in Type 2 Diabetes Remission.	International Journal of Molecular Sciences	2022
36134336	Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.	iScience	2022
36060810	In depth functional characterization of human induced pluripotent stem cell-derived beta cells and .	Frontiers in Cell and Developmental Biology	2022
35602948	NR5A2/LRH-1 regulates the PTGS2-PGE<sub>2</sub>-PTGER1 pathway contributing to pancreatic islet survival and function.	iScience	2022
36415826	A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.	NAR Genomics and Bioinformatics	2022
36518246	ADAR1-dependent editing regulates human Î²Â cell transcriptome diversity during inflammation.		2022
34417266	From Pancreatic Î²-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.		2021
34241569	A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.	Islets	2021
33486469	DNAJC3 deficiency induces Î²-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.	European Journal of Endocrinology	2021
34056599	Correction to 'Integration of single-cell datasets reveals novel transcriptomic signatures of Î²-cells in human type 2 diabetes'.	NAR Genomics and Bioinformatics	2021
33523973	Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis.	Science advances	2021
33669901	Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.	Biomolecules	2021
33462408	Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus.	Cell Death and Differentiation	2021
33773604	Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.	Autoimmunity Highlights	2021
33376132	The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic Î²-cells.	Life Science Alliance	2021
34407177	The Pancreatic Ã¿-cell Response to Secretory Demands and Adaption to Stress.	Endocrinology	2021
34561224	CD8<sup>+</sup> T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes.	Diabetes	2021
34721418	A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.	Frontiers in Immunology	2021
34957512	The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets.		2021
34819394	100 YEARS OF INSULIN: 100 years of insulin: progress, current perspectives and future challenges.	Journal of Endocrinology	2021
34644572	TIGER: The gene expression regulatory variation landscape of human pancreatic islets.	Cell Rep	2021
34697029	The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets.		2021
33159537	SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells.	Journal of Molecular Medicine	2020
32072192	Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability.	Diabetologia	2020
32417218	The pancreatic beta cells: Still much to be learned.	Seminars in Cell and Developmental Biology	2020
31900242	Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.	Stem Cell Research and Therapy	2020
32398822	Pancreatic Î²-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.	Nature Reviews Endocrinology	2020
31877117	Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia.	JCI Insight	2020