Author details

Full Name

Kevin Eggan

Affiliation

ORCID

Career Start Year

2000

Papers

150

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37500887	Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.	Nat Immunol	2023
37207277	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	iScience	2023
36640364	Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.		2023
36950384	Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.	Cell Genom	2023
36796362	Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages.		2023
35176052	Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen.	PLoS ONE	2022
35760976	The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.	Nat Commun	2022
35680907	Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues.	Nature Communications	2022
36417722	A Multimodal and Multifunctional CMOS Cellular Interfacing Array for Digital Physiology and Pathology Featuring an Ultra Dense Pixel Array and Reconfigurable Sampling Rate.		2022
36480942	Loss of mouse Stmn2 function causes motor neuropathy.		2022
35341748	Spinal motor neuron transplantation to enhance nerve reconstruction strategies: Towards a cell therapy.	Experimental Neurology	2022
35312356	Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS.	Proceedings of the National Academy of Sciences of the United States of America	2022
35294901	Loss of mouse Stmn2 function causes motor neuropathy.	Neuron	2022
34910584	A multiparametric activity profiling platform for neuron disease phenotyping and drug screening.	Mol Biol Cell	2022
35176222	Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation.	Cell Stem Cell	2022
34416176	De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells.	Stem Cell Reports	2021
33972534	Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data.	Nat Commun	2021
34107252	Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation.	Cell Reports	2021
33832769	Connecting TDP-43 Pathology with Neuropathy.	Trends in Neurosciences	2021
33557935	Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.	Molecular Autism	2021
33226425	Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.	JAMA Neurol	2021
33433329	Retraction Notice to: Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells.		2021
33321073	Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells.		2021
34883504	Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia.	Complex Psychiatry	2021
33022228	Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice.	Neuron	2020
31857710	Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.	Nat Neurosci	2020
31959800	A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells.	Scientific Reports	2020
32483373	C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.	Nature	2020
33659408	Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus.	Bio-protocol	2020
31533043	A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.	Cell Rep	2019
31789594	Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9.	eLife	2019
31768050	Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.	Nat Neurosci	2019
30446391	A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.	Mol Ther	2019
30643292	ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.	Nature Neuroscience	2019
31543368	Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells.		2019
30962586	Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder.	Nat Biomed Eng	2019
30664768	Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.	Nat Neurosci	2019
31548358	RNA-seq as a tool for evaluating human embryo competence.	Genome Research	2019
29779896	All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.	Stem Cell Reports	2018
30120633	Hippo signaling in the ovary and polycystic ovarian syndrome.		2018
29973287	Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.	Acta Neuropathol Commun	2018
30352993	Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development.	Transl Psychiatry	2018
30337375	Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.	Development	2018
29950492	The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.	Genes Dev	2018
30275587	All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.	Nature Methods	2018
30410030	Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.	Transl Psychiatry	2018
29549319	Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium.	Nat Neurosci	2018
29802307	TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.	Sci Rep	2018
29791859	Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.	Cell Reports	2018
29107592	Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons.	Stem Cell Reports	2017