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Author Details

Neeltje Steeghs
Netherlands Cancer Institute-Antoni Van Leeuwenhoek
2003
175
35
PMIDPaper TitleJournal TitlePublished Year
37348074Clinical Relevance of High Plasma Trough Levels of the Kinase Inhibitors Crizotinib, Alectinib, Osimertinib, Dabrafenib, and Trametinib in NSCLC Patients.Ther Drug Monit2024
37906253Are novel oral oncolytics underdosed in obese patients?Cancer Chemother Pharmacol2024
37939124Olaparib plus Durvalumab, with or without Bevacizumab, as Treatment in PARP Inhibitor-Naïve Platinum-Sensitive Relapsed Ovarian Cancer: A Phase II Multi-Cohort Study.Clin Cancer Res2024
37982822Phase I Study of Elraglusib (9-ING-41), a Glycogen Synthase Kinase-3β Inhibitor, as Monotherapy or Combined with Chemotherapy in Patients with Advanced Malignancies.Clin Cancer Res2024
36282874Combination of the STING Agonist MIW815 (ADU-S100) and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-Label, Multicenter, Phase Ib Study.Clin Cancer Res2023
37598656Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study.Eur J Cancer2023
37597246Phase Ib/II Study of the Efficacy and Safety of Binimetinib (MEK162) Plus Panitumumab for Mutant or Wild-Type RAS Metastatic Colorectal Cancer.Oncologist2023
37856077The association of having a monitoring or blunting coping style with psychological distress, health-related quality of life and satisfaction with healthcare in gastrointestinal stromal tumour (GIST) patients.Acta Oncol2023
37902257Therapeutic drug monitoring to personalize dosing of imatinib, sunitinib, and pazopanib: A mixed methods study on barriers and facilitators.Cancer Med2023
37584840Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.Clin Pharmacokinet2023
37828717The use of microtracers in food-effect trials: An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib.Clin Transl Sci2023
37686693Genomic Alterations Associated with Estrogen Receptor Pathway Activity in Metastatic Breast Cancer Have a Differential Impact on Downstream ER Signaling.Cancers (Basel)2023
37814179Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GISTs) is Effective and Safe: Results from a Prospective Single-Center Study with 108 Patients.Ann Surg Oncol2023
37125403Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer.EClinicalMedicine2023
36947208Exposure-response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients.Cancer Chemother Pharmacol2023
36944815Exposure-Response Analyses of Olaparib in Real-Life Patients with Ovarian Cancer.Pharm Res2023
37246093Local treatment in metastatic GIST patients: A multicentre analysis from the Dutch GIST Registry.Eur J Surg Oncol2023
37079223Improved Efficacy of First-Line Imatinib in Advanced Gastrointestinal Stromal Tumors (GIST): The Dutch GIST Registry Data.Target Oncol2023
37444404Framework for Implementing Individualised Dosing of Anti-Cancer Drugs in Routine Care: Overcoming the Logistical Challenges.Cancers (Basel)2023
37310647CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer Patients.Clin Pharmacokinet2023
37173151Elevated preoperative serum interleukin-6 level is predictive for worse postoperative outcome after soft tissue sarcoma surgery.Eur J Surg Oncol2023
37172331Design and statistics of pharmacokinetic drug-drug, herb-drug, and food-drug interaction studies in oncology patients.Biomed Pharmacother2023
37236033WEE1 inhibitor adavosertib in combination with carboplatin in advanced TP53 mutated ovarian cancer: A biomarker-enriched phase II study.Gynecol Oncol2023
36969063Therapeutic drug monitoring guided dosing versus standard dosing of alectinib in advanced ALK positive non-small cell lung cancer patients: Study protocol for an international, multicenter phase IV randomized controlled trial (ADAPT ALEC).Front Oncol2023
37194167Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT-enhanced estimate of renal function.Br J Clin Pharmacol2023
37062209Local recurrence in primary localised resected gastrointestinal stromal tumours: A registry observational national cohort study including 912 patients.Eur J Cancer2023
36409435A phase 1 open-label study to assess the relative bioavailability of TAK-931 tablets in reference to powder-in-capsule in patients with advanced solid tumors.Invest New Drugs2023
36621142Identifying somatic changes in drug transporters using whole genome and transcriptome sequencing data of advanced tumors.Biomed Pharmacother2023
36689692Tarlatamab, a First-in-Class DLL3-Targeted Bispecific T-Cell Engager, in Recurrent Small-Cell Lung Cancer: An Open-Label, Phase I Study.J Clin Oncol2023
36893690Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.Cancer Treat Rev2023
34727226Taste, smell and mouthfeel disturbances in patients with gastrointestinal stromal tumors treated with tyrosine-kinase inhibitors.Support Care Cancer2022
35775126Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer.Clin Transl Sci2022
35653981Quality of life with encorafenib plus cetuximab with or without binimetinib treatment in patients with BRAF V600E-mutant metastatic colorectal cancer: patient-reported outcomes from BEACON CRC.ESMO Open2022
35352280Ritonavir-Boosted Exposure of Kinase Inhibitors: an Open Label, Cross-over Pharmacokinetic Proof-of-Concept Trial with Erlotinib.Pharm Res2022
35406604Health-Related Quality of Life and Side Effects in Gastrointestinal Stromal Tumor (GIST) Patients Treated with Tyrosine Kinase Inhibitors: A Systematic Review of the Literature.Cancers (Basel)2022
35834987Feasibility of therapeutic drug monitoring of sorafenib in patients with liver or thyroid cancer.Biomed Pharmacother2022
35397932Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management.Semin Oncol2022
35426526Is age just a number? A population pharmacokinetic study of gemcitabine.Cancer Chemother Pharmacol2022
35777707Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study.Ann Oncol2022
36520526Sample Bias in Web-Based Patient-Generated Health Data of Dutch Patients With Gastrointestinal Stromal Tumor: Survey Study.JMIR Form Res2022
36463731Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics.ESMO Open2022
36493601Sex differences in patients with gastrointestinal stromal tumours: do they exist and does it affect survival?ESMO Open2022
36481665Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.Nat Commun2022
36374447Dutch Gastrointestinal Stromal Tumor (GIST) Registry Data Comparing Sunitinib with Imatinib Dose Escalation in Second-Line Advanced Non-KIT Exon 9 Mutated GIST Patients.Target Oncol2022
36097345Manufacturing-dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development.Clin Transl Sci2022
36055309The QT interval prolongation potential of anticancer and supportive drugs: a comprehensive overview.Lancet Oncol2022
36055228Detection and localization of early- and late-stage cancers using platelet RNA.Cancer Cell2022
35980618Activity of Cabazitaxel in Metastatic or Inoperable Locally Advanced Dedifferentiated Liposarcoma: A Phase 2 Study of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG).JAMA Oncol2022
35978149Exposure-Response Analysis of Osimertinib in EGFR Mutation Positive Non-Small Cell Lung Cancer Patients in a Real-Life Setting.Pharm Res2022
36185303Beta-adrenergic receptor blockade in angiosarcoma: Which beta-blocker to choose?Front Oncol2022
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Collaborators

Department of Pharmaceutical Sciences, Utrecht University
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Erasmus MC Cancer Institute, University Medical Center Rotterdam
Co-authored papers 27
Erasmus MC Cancer Institute
Co-authored papers 23
Hartwig Medical Foundation
Co-authored papers 14
The Netherlands Cancer Institute
Co-authored papers 13
Erasmus Medical Center (MC) Cancer Institute
Co-authored papers 6
Erasmus MC Cancer Institute
Co-authored papers 5
Center for Statistics, Hasselt University
Co-authored papers 4
Franciscus Gasthuis & Vlietland Hospital Rotterdam and Schiedam
Co-authored papers 4
Princess Margaret Cancer Centre, University Ave
Co-authored papers 3
Center for Molecular Medicine, University Medical Center Utrecht
Co-authored papers 3
Department of Immunology Erasmus University Medical Center
Co-authored papers 3
University of Texas MD Anderson Cancer Center
Co-authored papers 3
University of Zagreb
Co-authored papers 2
McGill University
Co-authored papers 2
Leiden Institute of Advanced Computer Science, Leiden University
Co-authored papers 2
Center for Molecular Medicine, University Medical Center Utrecht
Co-authored papers 2
Radboud University Medical Center
Co-authored papers 2
The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital
Co-authored papers 2
Ontario Institute for Cancer Research Toronto
Co-authored papers 2
Sloan Kettering Institute
Co-authored papers 2
The Netherlands Cancer Institute
Co-authored papers 2
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 2
Cancer Center Amsterdam
Co-authored papers 2
Radboud university medical center
Co-authored papers 2
Co-authored papers 2
University Hospital Zurich
Co-authored papers 1
Sylvester Comprehensive Cancer Center, University of Miami
Co-authored papers 1
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University of California san francisco
Co-authored papers 1