Author details

Full Name

Charlie Hatton

Affiliation

ORCID

Career Start Year

1997

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36455613	Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.	Cancer Discov	2023
37591951	KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.	Nat Cell Biol	2023
37478846	UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.	Mol Cell	2023
36922589	MEN1 mutations mediate clinical resistance to menin inhibition.	Nature	2023
34582559	The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.	Blood	2022
35499757	MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.	Cancer Discov	2022
35534777	IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.	Nat Cancer	2022
34465866	YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.	Leukemia	2022
35245435	MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.	Mol Cell	2022
32575123	Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts.	Blood	2020
32001657	Therapeutic targeting of preleukemia cells in a mouse model of <i>NPM1</i> mutant acute myeloid leukemia.	Science	2020
30559381	Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.	Nature	2019
31821784	A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.	Cancer Cell	2019
27875550	An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.	PLoS One	2016
26759243	Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response.	Cancer Research	2016
26837761	Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.	Cancer Research	2016
27056325	Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.	Journal of Biological Chemistry	2016
26731516	Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.	eLife	2016
27411486	Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.	eLife	2016
27169995	Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment.	Clinical Cancer Research	2016
25157968	Prospective enterprise-level molecular genotyping of a cohort of cancer patients.	J Mol Diagn	2014
25457180	EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.		2014
24066160	Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.	PLoS One	2013
22829774	Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.	PLoS Genet	2012
22460905	The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.	Nature	2012
21209378	High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.	Blood	2011
22328973	Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.	Cancer Discov	2011
20601955	Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.	Nat Genet	2010
19915144	MEK1 mutations confer resistance to MEK and B-RAF inhibition.	Proc Natl Acad Sci U S A	2009
19924296	Profiling critical cancer gene mutations in clinical tumor samples.	PLoS One	2009
18552176	Drug-sensitive FGFR2 mutations in endometrial carcinoma.	Proc Natl Acad Sci U S A	2008
18077431	Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.	Proc Natl Acad Sci U S A	2007
16324910	Using UMLS metathesaurus concepts to describe medical images: dermatology vocabulary.	Comput Biol Med	2006
9199635	Continuing medical education on the World Wide Web (WWW). Interactive pathology case studies on the Internet.	Arch Pathol Lab Med	1997
9357660	Application of UMLS indexing systems to a WWW-based tool for indexing of digital images.	Proc AMIA Annu Fall Symp	1997