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Author Details

Aniruddha J Deshpande
Sanford Burnham Prebys Medical Discovery Institute
2004
49
25
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38048593Transcriptional control of leukemogenesis by the chromatin reader SGF29.Blood2024
36264490Detection of TP53 Mutation in Acute Myeloid Leukemia by RT-PCR-Based Sanger Sequencing.Methods Mol Biol2023
37995701DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity.Stem Cell Reports2023
37945900Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma.Nat Genet2023
38049829Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.Mol Cancer2023
37601659Therapeutic targeting of leukemia stem cells in acute myeloid leukemia.Front Oncol2023
37022737Silencing with SAFB: a new role for HOXA9 in AML.Blood2023
37082953The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.Development2023
34896393Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.J Biol Chem2022
35577818Author Correction: A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing.Nat Commun2022
35712672The Role of DOT1L in Normal and Malignant Hematopoiesis.Front Cell Dev Biol2022
36313423Biphasic cell cycle defect causes impaired neurogenesis in down syndrome.Front Genet2022
34907396Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.Nat Neurosci2022
35022500Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis.Leukemia2022
34226546The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.Nat Commun2021
34764240A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing.Nat Commun2021
34518534The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.Nat Commun2021
32424282Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.Nat Neurosci2020
32634241Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML.Blood Adv2020
32768595Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.Gastroenterology2020
32839770SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells.bioRxiv2020
30663717Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays.J Vis Exp2019
31393631The role of TP53 in acute myeloid leukemia: Challenges and opportunities.Genes Chromosomes Cancer2019
29692408The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.Nat Commun2018
29527516Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia.Front Oncol2018
27827825Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus.Blood2017
28202522Histone Acetyltransferase Activity of MOF Is Required for <i>MLL-AF9</i> Leukemogenesis.Cancer Res2017
26878175MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.J Clin Invest2016
26487272Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo.Leukemia2016
27535106Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.Cancer Discov2016
25822366DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Nat Med2015
26439302The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.Mol Cell2015
25079327DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.Nature2014
25464900AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.Cancer Cell2014
23138183Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.Leukemia2013
23361907Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.Blood2013
22867873Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Trends Immunol2012
21681188The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.Leukemia2011
19443658Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.Blood2009
19582419Identification of murine and human acute myeloid leukemia stem cells.Methods Mol Biol2009
198230253'UTR mediated regulation of the cyclin D1 proto-oncogene.Cell Cycle2009
17855634Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia.Blood2008
19383357The CALM and CALM/AF10 interactor CATS is a marker for proliferation.Mol Oncol2008
18316418A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis.J Exp Med2008
17329976Lymphoid progenitors as candidate cancer stem cells in AML: new perspectives.Cell Cycle2007
18371398Knocking the Wnt out of the sails of leukemia stem cell development.Cell Stem Cell2007
17097559Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.Cancer Cell2006
16025155The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.J Clin Invest2005
14718672Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.Proc Natl Acad Sci U S A2004
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Collaborators

Scott A Armstrong
Boston Children's Hospital
Co-authored papers 14
Anagha Deshpande
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 9
Nan Zhu
Shanghai General Hospital, Shanghai Jiaotong University
Co-authored papers 7
Amit U Sinha
Memorial Sloan Kettering Cancer Center
Co-authored papers 6
Richard Koche
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Co-authored papers 4
Ze'ev Ronai
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
Eytan Ruppin
National Cancer Institute
Co-authored papers 4
James E Bradner
Co-authored papers 4
Robert J Wechsler-Reya
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
Bo-Rui Chen
National Taiwan Ocean University
Co-authored papers 3
Lin Qi
Xiangya Hospital of Central South University
Co-authored papers 2
Jessica M Rusert
University of California San Diego
Co-authored papers 2
Nina Thiessen
Co-authored papers 2
Robert G Roeder
the Rockefeller University
Co-authored papers 2
Richard A Moore
Co-authored papers 2
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Rady Children's Hospital San Diego.
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Discovery and Preclinical Sciences
Co-authored papers 2
Yussanne Ma
Co-authored papers 2
Anca Sorana Morrissy
Cumming School of Medicine, University of Calgary
Co-authored papers 2
John G Doench
Co-authored papers 2
Marco A Marra
University of British Columbia
Co-authored papers 2
Yongmei Feng
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Florence M G Cavalli
Institut Curie, PSL Research University
Co-authored papers 2
Steven J M Jones
University of British Columbia
Co-authored papers 2
Vijay Ramaswamy
Hospital for Sick Children
Co-authored papers 2
Hamza Farooq
BioBox Analytics Inc.
Co-authored papers 2
Xiao-Nan Li
Northwestern University
Co-authored papers 2
Carl F Ware
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Co-authored papers 2
Rabi Murad
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Co-authored papers 2
James M Olson
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