Author details

Full Name

Roberto Sanchez

Affiliation

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
34812843	An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.	J Exp Med	2022
35897808	Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid.	Int J Mol Sci	2022
36128717	Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.	Open Biol	2022
34535664	A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.	Nat Commun	2021
36540756	Photochemical control of drug efficacy - a comparison of uncaging and photoswitching ifenprodil on NMDA receptors.	ChemPhotoChem	2021
33602808	Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.	Proc Natl Acad Sci U S A	2021
33781745	Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes.	J Biol Chem	2021
34604860	Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators.	J Cell Signal	2021
32160276	DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.	Hum Mol Genet	2020
32051230	GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human Î² cell regeneration.	Sci Transl Med	2020
31821176	Pharmacologic and genetic approaches define human pancreatic Î² cell mitogenic targets of DYRK1A inhibitors.	JCI Insight	2020
32633484	Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex.	ACS Chem Biol	2020
32340326	Structure-Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human Î²-Cell Proliferation.	Molecules	2020
29157977	Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.	Nanomedicine	2018
30059217	Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human Î²-Cell Proliferation.	J Med Chem	2018
29681544	Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.	Stem Cell Reports	2018
27001857	Suramin inhibits cullin-RING E3 ubiquitin ligases.	Proc Natl Acad Sci U S A	2016
27769355	Structural features and inhibitors of bromodomains.	Drug Discov Today Technol	2016
27654292	Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication.	J Virol	2016
26910498	In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy.	J Cell Biochem	2016
25751815	A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.	Nat Med	2015
26068603	Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.	Nat Commun	2015
24470572	ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains.	Bioinformatics	2014
24746559	Privileged diazepine compounds and their emergence as bromodomain inhibitors.	Chem Biol	2014
24912152	Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.	Proc Natl Acad Sci U S A	2014
24686119	The bromodomain: from epigenome reader to druggable target.	Biochim Biophys Acta	2014
23151229	Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation.	AIDS Res Hum Retroviruses	2013
22368247	SiteComp: a server for ligand binding site analysis in protein structures.	Bioinformatics	2012
22928775	Scaling the druggability landscape of human bromodomains, a new class of drug targets.	J Med Chem	2012
22619105	Automated identification of binding sites for phosphorylated ligands in protein structures.	Proteins	2012
21301906	Systematic assessment of accuracy of comparative model of proteins belonging to different structural fold classes.	J Mol Model	2011
21514168	The PHD finger: a versatile epigenome reader.	Trends Biochem Sci	2011
21537951	Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures.	J Struct Funct Genomics	2011
20126658	Biochemical profiling of histone binding selectivity of the yeast bromodomain family.	PLoS One	2010
18636505	Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites.	Proteins	2009
19627087	Modern homology modeling of G-protein coupled receptors: which structural template to use?	J Med Chem	2009
19789268	EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures.	Bioinformatics	2009
19736624	The role of human bromodomains in chromatin biology and gene transcription.	Curr Opin Drug Discov Devel	2009
19398430	SITEHOUND-web: a server for ligand binding site identification in protein structures.	Nucleic Acids Res	2009
19217386	Outcome of a workshop on applications of protein models in biomedical research.	Structure	2009
18631402	Systematic analysis of the effect of multiple templates on the accuracy of comparative models of protein structure.	BMC Struct Biol	2008
16423846	Variable gap penalty for protein sequence-structure alignment.	Protein Eng Des Sel	2006
15647507	Accuracy of structure-derived properties in simple comparative models of protein structures.	Nucleic Acids Res	2005
14759370	Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.	Mol Cell	2004
15296739	Systematic analysis of added-value in simple comparative models of protein structure.	Structure	2004
15292138	Bacillus subtilis YhcR, a high-molecular-weight, nonspecific endonuclease with a unique domain structure.	J Bacteriol	2004
15254232	Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta.	Mol Cell Biol	2004
11790853	Statistical potentials for fold assessment.	Protein Sci	2002
12399495	Bacillus subtilis YhaM, a member of a new family of 3'-to-5' exonucleases in gram-positive bacteria.	J Bacteriol	2002
12408817	The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.	Mol Cell	2002

1 - 50 of 62

Mark N Wass

University of Kent

Career Start Year 2007

Number of shared co-authors 1

Narcis Fernandez-Fuentes

Institute of Biological, Aberystwyth University

Career Start Year 2002

Number of shared co-authors 5

Yang Zhang

University of Michigan ann arbor

Career Start Year 2002

Number of shared co-authors 11

Hao Fan

College of Biotechnology and Bioengineering, Zhejiang University of Technology

Career Start Year 2001

Number of shared co-authors 5

Jun-Tao Guo

University of North Carolina at Charlotte

Career Start Year 1999

Number of shared co-authors 0

Jeffrey B Bonanno

Albert Einstein College of Medicine

Career Start Year 1999

Number of shared co-authors 11

Jo??o P G L M Rodrigues

Stanford University

Career Start Year 1999

Number of shared co-authors 5

David R Hall

Diamond Light Source Ltd, Harwell Science & Innovation Campus

Career Start Year 1998

Number of shared co-authors 5

Daisuke Kihara

Purdue University

Career Start Year 1997

Number of shared co-authors 10

Kentaro Tomii

National Institute of Advanced Industrial Science and Technology (AIST)

Career Start Year 1996

Number of shared co-authors 3

Lukasz Jaroszewski

University of California Riverside School of Medicine

Career Start Year 1995

Number of shared co-authors 7

Aw Edith Chan

The Walter and Eliza Hall Institute of Medical Research

Career Start Year 1993

Number of shared co-authors 2

Robert B Russell

Heidelberg University

Career Start Year 1991

Number of shared co-authors 1

Baldo Oliva

Universitat Pompeu Fabra

Career Start Year 1991

Number of shared co-authors 4

Gerard J Kleywegt

European Bioinformatics Institute (EMBL-EBI)

Career Start Year 1990

Number of shared co-authors 11

Carlos J Camacho

University of Pittsburgh

Career Start Year 1990

Number of shared co-authors 2

Ram Samudrala

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo

Career Start Year 1990

Number of shared co-authors 5

Paul A Bates

The Francis Crick Institute

Career Start Year 1989

Number of shared co-authors 4

Ramanathan Sowdhamini

Indian Institute of Science

Career Start Year 1989

Number of shared co-authors 1

Wladek Minor

University of Virginia

Career Start Year 1989

Number of shared co-authors 11

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 4

Christopher W V Hogue

National University of Singapore

Career Start Year 1987

Number of shared co-authors 2

Mark S Johnson

Abo Akademi University

Career Start Year 1985

Number of shared co-authors 1

Ruben Abagyan

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

Career Start Year 1981

Number of shared co-authors 1

Chris Sander

Broad Institute of MIT and Harvard

Career Start Year 1979

Number of shared co-authors 9

Michael J E Sternberg

Imperial College London

Career Start Year 1976

Number of shared co-authors 6

Shoshana J Wodak

VIB-VUB Center for Structural Biology

Career Start Year 1975

Number of shared co-authors 8

Stephen H Bryant

National Center for Biotechnology Information

Career Start Year 1973

Number of shared co-authors 14

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 4

Jens Meiler

Vanderbilt University

Career Start Year 1954

Number of shared co-authors 11

row(s) 1 - 30 of 30

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 14

Sander M Houten

Co-authored papers 4

Mihaly Mezei

Co-authored papers 3

Francisco Melo

Pontificia Universidad Catolica de Chile

Co-authored papers 3

Ursula Pieper

University of California san francisco

Co-authored papers 3

Marc A Marti-Renom

Universitat Pompeu Fabra (UPF)

Co-authored papers 3

Mallur S Madhusudhan

Indian Institute of Science Education and Research Pune

Co-authored papers 2

Ning Zheng

University of Washington

Co-authored papers 2

Nathaniel Heintz

Howard Hughes Medical Institute, The Rockefeller University

Co-authored papers 2

Lan Huang

University of California Irvine

Co-authored papers 2

Narayanan Eswar

University of California at San Francisco

Co-authored papers 2

Nebojsa Mirkovic

Weill Medical College of Cornell University

Co-authored papers 2

Andras Fiser

Albert Einstein College of Medicine

Co-authored papers 2

Michael Levitt

Stanford University

Co-authored papers 1

Terry Gaasterland

Scripps Institution of Oceanography, University of California San Diego

Co-authored papers 1

Dieter Egli

Co-authored papers 1

Gaetano T Montelione

Rensselaer Polytechnic Institute

Co-authored papers 1

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Co-authored papers 1

Stefan Bekiranov

University of Virginia

Co-authored papers 1

Stanley R Krystek

Bristol-Myers Squibb Pharmaceutical Research Institute

Co-authored papers 1

Ashley C Stuart

Columbia University

Co-authored papers 1

David Jones

The Francis Crick Institute

Co-authored papers 1

Aravind Subramanian

Co-authored papers 1

L Z Xu

Howard Hughes Medical Institute, The Rockefeller University

Co-authored papers 1

Julie M Miwa

Lehigh University.

Co-authored papers 1

Mark Schroeder

University of Missouri

Co-authored papers 1

Shuba Gopal

Broad Institute of Harvard and MIT

Co-authored papers 1

Steven E Brenner

University of California berkeley

Co-authored papers 1

Nabeel Bardeesy

Massachusetts General Hospital

Co-authored papers 1

Dora Dias-Santagata

Co-authored papers 1

1 - 30

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