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Author Details

David E Root
Broad Institute of Harvard and MIT
1993
175
83
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37205492Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.bioRxiv2023
37612728Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal.Genome Biol2023
37286821Genome-wide pooled CRISPR screening in neurospheres.Nat Protoc2023
37024492Mapping the landscape of genetic dependencies in chordoma.Nat Commun2023
37205492Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.bioRxiv2023
37612728Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal.Genome Biol2023
37024492Mapping the landscape of genetic dependencies in chordoma.Nat Commun2023
37286821Genome-wide pooled CRISPR screening in neurospheres.Nat Protoc2023
35105861PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.Nat Commun2022
35773251Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.Nat Commun2022
36305736BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.Cancer Discov2022
35831509Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.Nature2022
35437317Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer.Nat Cancer2022
36151395In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.Nat Immunol2022
35537449NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.Mol Cell2022
36591611Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.Gut2022
35332332Systematic identification of biomarker-driven drug combinations to overcome resistance.Nat Chem Biol2022
35016204Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion.Blood Adv2022
35105861PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.Nat Commun2022
35773251Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.Nat Commun2022
35437317Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer.Nat Cancer2022
35537449NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.Mol Cell2022
35831509Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.Nature2022
36591611Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.Gut2022
36305736BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.Cancer Discov2022
36151395In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.Nat Immunol2022
35016204Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion.Blood Adv2022
35332332Systematic identification of biomarker-driven drug combinations to overcome resistance.Nat Chem Biol2022
33150374Progression signature underlies clonal evolution and dissemination of multiple myeloma.Blood2021
33579786LKB1/<i>STK11</i> Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.Cancer Discov2021
34161704Acquired Resistance to KRAS<sup>G12C</sup> Inhibition in Cancer.N Engl J Med2021
33883167Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.Cancer Discov2021
33510483Noncanonical open reading frames encode functional proteins essential for cancer cell survival.Nat Biotechnol2021
34260938Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.Cell Rep2021
34320363SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.Cell Rep2021
33152323Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer.Cell Metab2021
33150374Progression signature underlies clonal evolution and dissemination of multiple myeloma.Blood2021
34857952Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.Nat Genet2021
34930405Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects.Genome Biol2021
33883167Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.Cancer Discov2021
33510483Noncanonical open reading frames encode functional proteins essential for cancer cell survival.Nat Biotechnol2021
33579786LKB1/<i>STK11</i> Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.Cancer Discov2021
34857952Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.Nat Genet2021
34930405Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects.Genome Biol2021
34161704Acquired Resistance to KRAS<sup>G12C</sup> Inhibition in Cancer.N Engl J Med2021
34320363SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.Cell Rep2021
34260938Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.Cell Rep2021
33152323Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer.Cell Metab2021
32483149A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor.Nat Commun2020
32371585A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer.Mol Cancer Ther2020
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Collaborators

William C Hahn
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 68
John G Doench
Co-authored papers 42
Glenn S Cowley
Broad Institute of Harvard and MIT
Co-authored papers 38
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 36
Federica Piccioni
Co-authored papers 36
Francisca Vazquez
Broad Institute of MIT and Harvard
Co-authored papers 32
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 29
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 29
Barbara A Weir
Janssen Research and Development LLC
Co-authored papers 21
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 20
Serena J Silver
Co-authored papers 15
Matthew Meyerson
Broad Institute
Co-authored papers 14
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 14
Pablo Tamayo
University of California San Diego
Co-authored papers 14
Nir Hacohen
Broad Institute of MIT and Harvard
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Benjamin L Ebert
Co-authored papers 13
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 12
Rameen Beroukhim
Co-authored papers 11
Stuart L Schreiber
Broad Institute
Co-authored papers 10
Mukta Bagul
Co-authored papers 10
Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 10
Gad Getz
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 10
Anna C Schinzel
Co-authored papers 9
Jill P Mesirov
University of California San Diego
Co-authored papers 8
Brenton R Paolella
Co-authored papers 8
Anne E Carpenter
Broad Institute of MIT and Harvard
Co-authored papers 8
Brent R Stockwell
Columbia University
Co-authored papers 8
James E Bradner
Co-authored papers 8
Aravind Subramanian
Co-authored papers 8
Paul A Clemons
Broad Institute
Co-authored papers 8
Release 1.2