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Author Details

Jules A Hoffmann
Sino-French Hoffmann Institute, Guangzhou Medical University
1970
191
92
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36917667A Toll pathway effector protects <i>Drosophila</i> specifically from distinct toxins secreted by a fungus or a bacterium.Proc Natl Acad Sci U S A2023
37459549<i>mthl1</i>, a potential <i>Drosophila</i> homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies.Proc Natl Acad Sci U S A2023
36996781Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila.J Innate Immun2023
33737397A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of <i>Drosophila</i> immune defenses.Proc Natl Acad Sci U S A2021
31940269The Kinase IKKβ Regulates a STING-and NF-κB-Dependent Antiviral Response Pathway in Drosophila.Immunity2020
30119996The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.Immunity2018
27009948Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity.J Virol2016
26739560Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.Proc Natl Acad Sci U S A2016
24947515The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.J Biol Chem2014
25416947RACK1 controls IRES-mediated translation of viruses.Cell2014
25253354Drosophila C virus systemic infection leads to intestinal obstruction.J Virol2014
25107474Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.EMBO J2014
23255357Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.J Immunol2013
23749869Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.Proc Natl Acad Sci U S A2013
23452839Innate immunity.Curr Opin Immunol2013
23378635big bang gene modulates gut immune tolerance in Drosophila.Proc Natl Acad Sci U S A2013
22611248Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983.J Immunol2012
22916150Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.PLoS One2012
22450469On-bead tryptic proteolysis: an attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria.J Proteomics2012
21719711ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.Proc Natl Acad Sci U S A2011
20978209RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila.Proc Natl Acad Sci U S A2010
19286136Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.Cell Host Microbe2009
20457557NF-kappaB in the immune response of Drosophila.Cold Spring Harb Perspect Biol2009
19692333The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors.J Biol Chem2009
18066067Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.Nat Immunol2008
18953338The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.Nat Immunol2008
18474356The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation.Cell Host Microbe2008
17201680The host defense of Drosophila melanogaster.Annu Rev Immunol2007
17948019The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections.Nat Rev Immunol2007
17893693Genetic analysis of resistance to viral infection.Nat Rev Immunol2007
18039029A model of bacterial intestinal infections in Drosophila melanogaster.PLoS Pathog2007
17514202Antifungal defense in Drosophila.Nat Immunol2007
16322759Prophenoloxidase activation is not required for survival to microbial infections in Drosophila.EMBO Rep2006
17045818Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei.Immunity2006
17196037Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.PLoS Pathog2006
17190605Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors.Cell2006
16518472Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.PLoS Pathog2006
16554838Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.Nat Immunol2006
15679837New insights into Drosophila larval haemocyte functions through genome-wide analysis.Cell Microbiol2005
16239149Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.Cell2005
16086017The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.Nat Immunol2005
15653304Sensing and signaling during infection in Drosophila.Curr Opin Immunol2005
14751763Sensing infection in Drosophila: Toll and beyond.Semin Immunol2004
15556270Peptidomic and proteomic analyses of the systemic immune response of Drosophila.Biochimie2004
15373968Toll-dependent and Toll-independent immune responses in Drosophila.J Endotoxin Res2004
15448690Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.Nat Immunol2004
12792847Drosophila melanogaster antimicrobial defense.J Infect Dis2003
12872120Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.Nat Immunol2003
14603309The immune response of Drosophila.Nature2003
14525994Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.J Biol Chem2003
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Collaborators

Charles Hetru
CNRS UPR2, Institut de Biologie Moleculaire et Cellulaire
Co-authored papers 42
Bruno Lemaitre
Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL)
Co-authored papers 14
Carine Meignin
Co-authored papers 6
Hidehiro Fukuyama
Near-InfraRed Photo-Immunotherapy Research Institute, Kansai Medical University
Co-authored papers 4
Yann Verdier
PSL University, CNRS UMR9
Co-authored papers 3
Hans-Michael M??ller
Heidelberg University Biochemistry Center
Co-authored papers 3
Neal Silverman
Co-authored papers 3
Michael Boutros
German Cancer Research Center (DKFZ) and Heidelberg University
Co-authored papers 3
Jo??lle Vinh
Universite PSL, LPC CNRS UMR8249
Co-authored papers 3
Pierre Lepage
Co-authored papers 2
Jean Rossier
Sorbonne University
Co-authored papers 2
Xi Liu
Guangdong Pharmaceutical University
Co-authored papers 2
Silvia Naitza
Co-authored papers 2
Yongsheng Guan
College of Information Engineering, Xijing University
Co-authored papers 2
Iman Haddad
PSL Universite, CNRS
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Kenichiro Ono
Co-authored papers 1
Evgeny M Zdobnov
University of Geneva
Co-authored papers 1
Ivica Letunic
Co-authored papers 1
Chieko Makino-Okamura
Biosignal Research Center, Kobe University
Co-authored papers 1
Michael Ashburner
University of Cambridge
Co-authored papers 1
Elie Maksoud
Buck Institute for Research on Aging
Co-authored papers 1
Peer Bork
University of Wurzburg
Co-authored papers 1
Christos Samakovlis
Stockholm University, The Wenner-Gren Institute, Justus Liebig University of Giessen
Co-authored papers 1
Rainer Bischoff
Groningen Research Institute of Pharmacy, University of Groningen
Co-authored papers 1
Damarys Loew
Institut Curie, PSL Research University
Co-authored papers 1
Jun Matsubayashi
Tokyo Medical University
Co-authored papers 1
Victoria Y Shilova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
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Christian von Mering
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Trey Ideker (CM4AI)
University of California San Diego
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Release 1.2