Author details

Full Name

Nagi G Ayad

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37321420	An overview of human single-cell RNA sequencing studies in neurobiological disease.		2023
37650863	Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.	EMBO Rep	2023
35151865	A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion.	Bioorganic and Medicinal Chemistry Letters	2022
35925047	A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.	Molecular Cancer Research	2022
36556332	Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer.		2022
35314408	Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma.	World Neurosurgery	2022
35276206	BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion.	Experimental Neurology	2022
35118385	A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines.	Neurooncol Adv	2021
33613198	Organoid Models of Glioblastoma and Their Role in Drug Discovery.	Frontiers in Cellular Neuroscience	2021
34862404	The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion.	Scientific Reports	2021
34489457	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.	Nature Communications	2021
33015071	Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival.	Frontiers in Cell and Developmental Biology	2020
32877743	Epigenetic pathways and plasticity in brain tumors.	Neurobiology of Disease	2020
33192321	Neuroinflammation Treatment via Targeted Delivery of Nanoparticles.	Frontiers in Cellular Neuroscience	2020
30819207	Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.	Environmental Health: A Global Access Science Source	2019
30487124	A CK1Î± Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.	Clin Cancer Res	2019
31292434	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.	Nat Commun	2019
29558959	Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.	Molecular Cancer	2018
30552330	Drug and disease signature integration identifies synergistic combinations in glioblastoma.	Nat Commun	2018
29917015	Sustainable data and metadata management at the BD2K-LINCS Data Coordination and Integration Center.	Sci Data	2018
30483476	Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme.	Frontiers in Oncology	2018
30134146	Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury.	Experimental Neurology	2018
29615902	Drug Repositioning in Glioblastoma: A Pathway Perspective.	Front Pharmacol	2018
28296622	A cell based screening approach for identifying protein degradation regulators.	Cell Cycle	2017
28714964	Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.	Oncogene	2017
28884163	Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.	ACS Omega	2017
27073358	Casein kinase signaling in axon regeneration.	Neural Regeneration Research	2016
26111795	The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.	Proceedings of the National Academy of Sciences of the United States of America	2015
25290986	Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.	J Cell Biochem	2015
25843713	Casein kinase 1Î´ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.	Cell Rep	2015
25616418	GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.	Cell Cycle	2015
25606665	Screening of cell cycle fusion proteins to identify kinase signaling networks.	Cell Cycle	2015
26219466	The APC/C and CK1 in the developing brain.	Oncotarget	2015
26596901	Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.	Sci Rep	2015
25129342	Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.	Breast Cancer Research and Treatment	2014
25551752	Identifying glioblastoma gene networks based on hypergeometric test analysis.	PLoS One	2014
25355313	The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.	Journal of Biological Chemistry	2014
24496381	BET bromodomain proteins are required for glioblastoma cell proliferation.	Epigenetics	2014
24817118	Casein kinase 1Î´-dependent Wee1 protein degradation.	J Biol Chem	2014
23807265	Epigenetic pathways and glioblastoma treatment.	Epigenetics	2013
22655255	The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis.	Frontiers in Oncology	2011
20660794	An ultra-high throughput cell-based screen for wee1 degradation inhibitors.	Journal of Biomolecular Screening	2010
20038582	Activation domain-dependent degradation of somatic Wee1 kinase.	Journal of Biological Chemistry	2010
19047054	The anaphase promoting complex induces substrate degradation during neuronal differentiation.	Journal of Biological Chemistry	2009
18032919	Redundant ubiquitin ligase activities regulate wee1 degradation and mitotic entry.	Cell Cycle	2007
16338372	Identification of ubiquitin ligase substrates by in vitro expression cloning.	Methods Enzymol	2005
15837422	Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.	Molecular Cell	2005
16179249	CDKs give Cdc6 a license to drive into S phase.	Cell	2005
14743218	The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex.	Nature Cell Biology	2004
15014503	Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.	Nature	2004