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Author Details

Briana C Prager
Massachusetts General Hospital
2015
43
25
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36394953Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.J Clin Invest2023
37746272Editorial: Epigenetic and metabolic regulation of primary and metastatic brain cancers.Front Oncol2023
37980347LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation.Nat Commun2023
37979586EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.Mol Cell2023
36795488Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting.JCI Insight2023
34615656Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells.Cancer Discov2022
35534562Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.Nat Genet2022
35393416CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity.Nat Commun2022
35659339PDGF signaling inhibits mitophagy in glioblastoma stem cells through N<sup>6</sup>-methyladenosine.Dev Cell2022
36091544A picture is worth a thousand words: A proposal to incorporate video into the evaluation of adults with intellectual or developmental disability living outside the home.Front Public Health2022
34903607Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.Cancer Res2022
35133980ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance.J Clin Invest2022
34985972Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.Sci Transl Med2022
33023892The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.Cancer Discov2021
33850013Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma.Proc Natl Acad Sci U S A2021
33594762Phage display targeting identifies EYA1 as a regulator of glioblastoma stem cell maintenance and proliferation.Stem Cells2021
34617969Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe.J Exp Med2021
34181729Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.Nucleic Acids Res2021
33328215CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies.Cancer Discov2021
32499560Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions.Cell Res2020
31956038Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α<sub>v</sub>β<sub>5</sub> Axis.Cell Stem Cell2020
32101725Glioblastoma Stem Cells: Driving Resilience through Chaos.Trends Cancer2020
33124191SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.EMBO Mol Med2020
32703768The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.Cancer Discov2020
30609398Cancer Stem Cells: The Architects of the Tumor Ecosystem.Cell Stem Cell2019
31455674Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.Cancer Discov2019
31201181Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling.Cancer Discov2019
31391321Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells.Sci Transl Med2019
30779712Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC.JCI Insight2019
30948495Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma.J Exp Med2019
29258295Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.Nature2018
30392959N<sup>6</sup>-methyladenine DNA Modification in Glioblastoma.Cell2018
29625067Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression.Cell Stem Cell2018
28874392Zika virus has oncolytic activity against glioblastoma stem cells.J Exp Med2017
28346452Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.Nat Neurosci2017
29035367Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.Nat Med2017
28679344Survey-based assessment of the relationship between cognitive impairment and mentally stimulating activity in multiple sclerosis.Neurol Res2017
28515364Nicotinamide metabolism regulates glioblastoma stem cell maintenance.JCI Insight2017
28916645Correction: Zika virus has oncolytic activity against glioblastoma stem cells.J Exp Med2017
28729418MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells.Cancer Res2017
26896279A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo.Cancer Res2016
25939882Sphingosine 1-phosphate signaling at the blood-brain barrier.Trends Mol Med2015
26668819Spatiotemporal ablation of CXCR2 on oligodendrocyte lineage cells: Role in myelin repair.Neurol Neuroimmunol Neuroinflamm2015
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Collaborators

Jeremy N Rich
UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Co-authored papers 38
Zhixin Qiu
UPMC Hillman Cancer Center
Co-authored papers 15
Stephen C Mack
St Jude Children's Research Hospital
Co-authored papers 13
Andrew E Sloan
Co-authored papers 6
Lukas Chavez
University of California San Diego
Co-authored papers 5
Sameer Agnihotri
Co-authored papers 3
Kui Zhai
Lerner Research Institute, Cleveland Clinic
Co-authored papers 3
David R Raleigh
University of California san francisco
Co-authored papers 3
Arie Perry
University of California san francisco
Co-authored papers 2
Pei-Yong Shi
University of Texas Medical Branch
Co-authored papers 2
Gene H Barnett
Co-authored papers 2
Harish N Vasudevan
University of California San Francisco
Co-authored papers 2
Paul S Mischel
Stanford University
Co-authored papers 2
Chao Shan
Wuhan Institute of Virology, Chinese Academy of Sciences
Co-authored papers 2
Peter C Scacheri
Case Western Reserve University School of Medicine
Co-authored papers 2
Milan G Chheda
Co-authored papers 2
Michael A Vogelbaum
Moffit Cancer Center
Co-authored papers 2
Robert J Wechsler-Reya
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Matthew J Gorman
Co-authored papers 2
Xiang-Dong Fu
Co-authored papers 2
Alysson R Muotri
Department of Pediatrics/Rady Children's Hospital, University of California San Diego
Co-authored papers 2
Michael S Diamond
Washington University School of Medicine
Co-authored papers 1
Marc Zapatka
Co-authored papers 1
Betty Luu
University of Wollongong
Co-authored papers 1
Peter J Houghton
The University of Texas Health Science Center at San Antonio
Co-authored papers 1
Annie Huang
Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children
Co-authored papers 1
David U Gorkin
Center for Epigenomics, University of California San Diego
Co-authored papers 1
Clark Chen
University of Minnesota
Co-authored papers 1
Tai-Chung Lam
University of Hong Kong
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Release 1.2