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Author Details

John E Ladbury
University of Leeds
1992
177
57
PMIDPaper TitleJournal TitlePublished Year
37777392The emerging role of receptor tyrosine kinase phase separation in cancer.Trends Cell Biol2024
37777392The emerging role of receptor tyrosine kinase phase separation in cancer.Trends Cell Biol2024
36759237Phase separation enhances probability of receptor signalling and drug targeting.Trends Biochem Sci2023
37813490Correction: Expansion microscopy reveals subdomains in <i>C. elegans</i> germ granules.Life Sci Alliance2023
37290059PLBD: protein-ligand binding database of thermodynamic and kinetic intrinsic parameters.Database (Oxford)2023
37328606Regulation of microRNA expression by the adaptor protein GRB2.Sci Rep2023
36759237Phase separation enhances probability of receptor signalling and drug targeting.Trends Biochem Sci2023
37452126The combined action of the intracellular regions regulates FGFR2 kinase activity.Commun Biol2023
36750365Expansion microscopy reveals subdomains in <i>C. elegans</i> germ granules.Life Sci Alliance2023
37813490Correction: Expansion microscopy reveals subdomains in <i>C. elegans</i> germ granules.Life Sci Alliance2023
37290059PLBD: protein-ligand binding database of thermodynamic and kinetic intrinsic parameters.Database (Oxford)2023
37452126The combined action of the intracellular regions regulates FGFR2 kinase activity.Commun Biol2023
37328606Regulation of microRNA expression by the adaptor protein GRB2.Sci Rep2023
36750365Expansion microscopy reveals subdomains in <i>C. elegans</i> germ granules.Life Sci Alliance2023
35231400Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.Mol Cell2022
36171279The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation.Commun Biol2022
35231400Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.Mol Cell2022
36171279The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation.Commun Biol2022
33945229Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.ChemistryOpen2021
33795832Grb2 binding induces phosphorylation-independent activation of Shp2.Commun Biol2021
33731760Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction.Sci Rep2021
33945229Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.ChemistryOpen2021
35052688Drug Resistance in Glioma Cells Induced by a Mesenchymal-Amoeboid Migratory Switch.Biomedicines2021
33795832Grb2 binding induces phosphorylation-independent activation of Shp2.Commun Biol2021
33731760Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction.Sci Rep2021
35052688Drug Resistance in Glioma Cells Induced by a Mesenchymal-Amoeboid Migratory Switch.Biomedicines2021
32194931A novel workflow for three-dimensional analysis of tumour cell migration.Interface Focus2020
32194931A novel workflow for three-dimensional analysis of tumour cell migration.Interface Focus2020
32843637DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.Nat Commun2020
32720471Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes.Mol Genet Genomic Med2020
32720471Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes.Mol Genet Genomic Med2020
32843637DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.Nat Commun2020
30597093H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.Nucleic Acids Res2019
30597093H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.Nucleic Acids Res2019
30929235Intrinsic Thermodynamics of Protein-Ligand Binding by Isothermal Titration Calorimetry as Aid to Drug Design.Methods Mol Biol2019
31072823Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.Biol Open2019
31051140A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.Mol Cell2019
31100409Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.Cancer Lett2019
31100409Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.Cancer Lett2019
31072823Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.Biol Open2019
31051140A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.Mol Cell2019
30929235Intrinsic Thermodynamics of Protein-Ligand Binding by Isothermal Titration Calorimetry as Aid to Drug Design.Methods Mol Biol2019
29208567Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.Int J Biochem Cell Biol2018
30061390FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.Proc Natl Acad Sci U S A2018
29967909Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.Chem Commun (Camb)2018
29208567Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.Int J Biochem Cell Biol2018
30912486Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design.Q Rev Biophys2018
29967909Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.Chem Commun (Camb)2018
30061390FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.Proc Natl Acad Sci U S A2018
30912486Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design.Q Rev Biophys2018
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Collaborators

Zamal Ahmed
The University of Texas MD Anderson Cancer Center
Co-authored papers 23
Stefan T Arold
Co-authored papers 17
Mark A Williams
Harwell Science & Innovation Campus
Co-authored papers 15
Paul C Driscoll
The Francis Crick Institute
Co-authored papers 5
Mien-Chie Hung
Co-authored papers 5
Carol V Robinson
University of Oxford
Co-authored papers 4
Iain D Campbell
University of Oxford
Co-authored papers 4
Mark Pfuhl
King's College London
Co-authored papers 4
Guillaume Poncet-Montange
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Co-authored papers 3
Ivan Dikic
Institute of Biochemistry II, Goethe University Frankfurt
Co-authored papers 2
Anil K Sood
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Cristina Ivan
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
David I Stuart
University of Oxford
Co-authored papers 2
Su-Chen Huang
Industrial Technology Research Institute
Co-authored papers 1
Gaetano T Montelione
Rensselaer Polytechnic Institute
Co-authored papers 1
Gordon B Mills
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Nicolas Stransky
Co-authored papers 1
Levi A Garraway
Broad Institute of Harvard and MIT
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Eran Hodis
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Alex H Ramos
Co-authored papers 1
Michael Noble
Co-authored papers 1
Jennifer R Grandis
University of California san francisco
Co-authored papers 1
Gad Getz
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 1
Anupama E Gururaj
National Institute of Allergy and Infectious Disease, National Institutes of Health
Co-authored papers 1
Liren Li
Co-authored papers 1
Kristian Cibulskis
Co-authored papers 1
Stephen Matthews
Imperial College London
Co-authored papers 1
Stacey Gabriel
Broad Institute of MIT and Harvard
Co-authored papers 1
Marcin Imielinski
Co-authored papers 1
Danielle DiCara
Co-authored papers 1
Release 1.2