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Author Details

Timothy P Heffernan
2002
83
44
PMIDPaper TitleJournal TitlePublished Year
36658425Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials.Nat Med2023
37634013Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL.2023
37786705Evolutionary fingerprints of EMT in pancreatic cancers.bioRxiv2023
37625401KRAS<sup>G12D</sup> inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8<sup>+</sup> T cells.Cancer Cell2023
36824971Oncogenic Kras <sup>G12D</sup> specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 <sup>+</sup> T cells dependent manner.bioRxiv2023
36627494Author Correction: Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.Nature2023
36747713Combined KRAS<sup>G12C</sup> and SOS1 inhibition enhances and extends the anti-tumor response in KRAS<sup>G12C</sup>-driven cancers by addressing intrinsic and acquired resistance.bioRxiv2023
37186844SMARCB1 regulates the hypoxic stress response in sickle cell trait.Proc Natl Acad Sci U S A2023
37055414Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1.Blood Cancer J2023
36689560Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma.Clin Cancer Res2023
37226898Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy.Clin Transl Med2023
35944232Shared Nearest Neighbors Approach and Interactive Browser for Network Analysis of a Comprehensive Non-Small-Cell Lung Cancer Data Set.JCO Clin Cancer Inform2022
35705814Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.Nature2022
34529467Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.Science2021
32073931Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.Int J Radiat Biol2021
33745946Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer.Gastroenterology2021
34117030Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition.Cancer Res2021
34108622Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1 mutations.Oncogene2021
33839689Oncogenic <i>KRAS</i> Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis.Cancer Discov2021
34330913PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.Nat Commun2021
32816843BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.Cancer Discov2021
33123754Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity.Cancer Immunol Immunother2021
33158812Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress.Cancer Res2021
34518211Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer.Cancer Res2021
34857765The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.NPJ Breast Cancer2021
34732714Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.Nat Commun2021
34777916Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in <i>Braf</i>-mutated melanoma.Oncoimmunology2021
34885132Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies.Cancers (Basel)2021
32787110Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.Journal of Medicinal Chemistry2020
31852834<i>EGFR</i> Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.Clin Cancer Res2020
32359397Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma.Cancer Cell2020
32928921Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib.Cancer Res2020
33118821Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.J Med Chem2020
30996079Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state.Sci Transl Med2019
31719531ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.Nat Commun2019
31557131YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma.JCI Insight2019
30625329Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.Cell Rep2019
30986992Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer.Cancers (Basel)2019
30867319ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.Sci Transl Med2019
30918400Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.Nature2019
30753823p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.Cancer Cell2019
31500168Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research.Cancers (Basel)2019
31068440Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma.Sci Transl Med2019
30726735Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors.Cell Rep2019
29496759The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression.Clin Cancer Res2018
29892070An inhibitor of oxidative phosphorylation exploits cancer vulnerability.Nat Med2018
30498242High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer.Nat Commun2018
30388424PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.Cell Stem Cell2018
29628419Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.Cell Metab2018
29267866The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy.J Natl Cancer Inst2018
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