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Author Details

Andrew J Elia
University Health Network, Princess Margaret Cancer Centre
1995
81
52
PMIDPaper TitleJournal TitlePublished Year
36736318IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.Cancer Cell2023
37640929Tumor-specific cholinergic CD4<sup>+</sup> T lymphocytes guide immunosurveillance of hepatocellular carcinoma.Nat Cancer2023
35167826Cisplatin toxicity in the developing brain displays an absolute requirement for caspase-3.Exp Neurol2022
36108220Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.Cancer Discov2022
32844322Necroptotic-Apoptotic Regulation in an Endothelin-1 Model of Cerebral Ischemia.Cell Mol Neurobiol2021
34518219Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer.Proc Natl Acad Sci U S A2021
33382742Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity.PLoS One2020
30733420Choline acetyltransferase-expressing T cells are required to control chronic viral infection.Science2019
31892360High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation.J Immunother Cancer2019
31741762Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer.Oncoimmunology2019
31073782Endothelin-1-mediated cerebral ischemia in mice: early cellular events and the role of caspase-3.Apoptosis2019
29378962Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.Proc Natl Acad Sci U S A2018
28137882E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.Proc Natl Acad Sci U S A2017
27058317Metabolic reprogramming during neuronal differentiation.Cell Death Differ2016
27424808Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Cancer Cell2016
27184401Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.Cell Stem Cell2016
26915295The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.Cell Death Differ2016
25620030Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.Cancer Cell2015
25882048Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.Cell Death Differ2015
23435421PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.Oncogene2014
24747746Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.Nat Med2014
24656129Largen: a molecular regulator of mammalian cell size control.Mol Cell2014
24449892TAp73 is required for spermatogenesis and the maintenance of male fertility.Proc Natl Acad Sci U S A2014
23708664Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells.Oncogene2014
22614012Lipocalin 2 performs contrasting, location-dependent roles in APCmin tumor initiation and progression.Oncogene2013
23857982BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.J Exp Med2013
23946427Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.Proc Natl Acad Sci U S A2013
23699408Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.Genes Dev2013
23787995Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo.Cell Death Differ2013
23412344Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model.Cell Death Differ2013
22213803The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.J Exp Med2012
232132422-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.Proc Natl Acad Sci U S A2012
22925884D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.Genes Dev2012
21636789Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.Proc Natl Acad Sci U S A2011
21597464Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.Cell Death Differ2011
21576264Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.Genes Dev2011
20133630Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.Proc Natl Acad Sci U S A2010
20543135Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.Proc Natl Acad Sci U S A2010
20566848Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.Proc Natl Acad Sci U S A2010
20679220Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.Proc Natl Acad Sci U S A2010
18550520Inhibition of apoptosome activation protects injured motor neurons from cell death.J Biol Chem2008
18835195Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.Immunity2008
16446425Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.Proc Natl Acad Sci U S A2006
15907471Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.Cell2005
15026330Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.Cancer Res2004
15343267Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.EMBO J2004
15492213grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.Proc Natl Acad Sci U S A2004
14757745Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.J Exp Med2004
12925852The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.Nat Immunol2003
11937492Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.Genes Dev2002
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Collaborators

Princess Margaret Cancer Centre, University Health Network
Co-authored papers 65
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
Co-authored papers 39
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 9
Division of Clinical Studies, The Institute of Cancer Research
Co-authored papers 9
Princess Margaret Cancer Centre
Co-authored papers 8
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Campbell Family Institute for Breast Cancer Research, University Health Network
Co-authored papers 5
University Health Network, University of Toronto
Co-authored papers 5
University Health Network
Co-authored papers 5
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Children's Hospital Research Foundation
Co-authored papers 3
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Oregon Health & Science University
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
The Hospital for Sick Children
Co-authored papers 2
University of Toronto.
Co-authored papers 2
University of Toronto
Co-authored papers 2
Princess Margaret Cancer Centre, University Avenue
Co-authored papers 2
University of Toronto
Co-authored papers 2
University of Sao Paulo
Co-authored papers 2
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 2
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 1
McGill University
Co-authored papers 1
Institute of Cancer Research
Co-authored papers 1
Translational Research Institute for Space Health
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1