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Author Details

William M Oldham
Harvard Medical School
2000
54
26
PMIDPaper TitleJournal TitlePublished Year
36599986Metabolic regulation of species-specific developmental rates.Nature2023
37546967Mechano-dependent sorbitol accumulation supports biomolecular condensate.bioRxiv2023
37257452Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome.Med2023
36949206Author Correction: Metabolic regulation of species-specific developmental rates.Nature2023
37276608Elevated Pulmonary Arterial Compliance Is Associated with Survival in Pulmonary Hypertension: Results from a Novel Network Medicine Analysis.Am J Respir Crit Care Med2023
37428010MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia.Elife2023
36626231Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension.JCI Insight2023
36043417L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling.Circ Res2022
36396654Author Correction: Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes.Nat Commun2022
34102109Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.Cell Metab2021
33738458Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.Nat Cancer2021
33558530Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes.Nat Commun2021
33890812Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism.Circ Res2021
33888254NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.J Am Coll Cardiol2021
33833034Integrating haemodynamics identifies an extreme pulmonary hypertension phenotype.Eur Respir J2021
34636650Interferon-γ Impairs Human Coronary Artery Endothelial Glucose Metabolism by Tryptophan Catabolism and Activates Fatty Acid Oxidation.Circulation2021
34625640Understanding critically ill sepsis patients with normal serum lactate levels: results from U.S. and European ICU cohorts.Sci Rep2021
33268556Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Cancer Res2020
30293773Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.Cell Metab2019
31862934Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions.Sci Rep2019
31121149Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension.Chest2019
31002526Paradoxical Embolization via Large Pulmonary Arteriovenous Malformation.Am J Respir Crit Care Med2019
30554082Innate T cells in the intensive care unit.Mol Immunol2019
28635300Pyridine Dinucleotides from Molecules to Man.Antioxid Redox Signal2018
30054282[<sup>18</sup>F]Fluorocholine and [<sup>18</sup>F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.Clin Cancer Res2018
30209366GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis.Nature2018
29899023NEDD9 targets <i>COL3A1</i> to promote endothelial fibrosis and pulmonary arterial hypertension.Sci Transl Med2018
29388834The Long Noncoding RNA LnRPT Puts the Brakes on Pulmonary Artery Smooth Muscle Cell Proliferation.Am J Respir Cell Mol Biol2018
29437835Network Analysis to Risk Stratify Patients With Exercise Intolerance.Circ Res2018
29757677MicroRNA Dysregulation in Pulmonary Arteries from Chronic Obstructive Pulmonary Disease. Relationships with Vascular Remodeling.Am J Respir Cell Mol Biol2018
29121773Systems Biology Approaches to Redox Metabolism in Stress and Disease States.Antioxid Redox Signal2018
29113451Nicotine Adenine Dinucleotides: The Redox Currency of the Cell.Antioxid Redox Signal2018
28512249p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Cancer Res2017
29029388Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.Oncotarget2017
27548520Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.J Clin Invest2016
28573160Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry.Bio Protoc2016
26586488Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study.J Heart Lung Transplant2016
27162614Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing.Pulm Circ2016
26212716Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.Cell Metab2015
26697168Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice.Pulm Circ2015
25001622Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis.Circulation2014
25530704Network-based association of hypoxia-responsive genes with cardiovascular diseases.New J Phys2014
21841905A workshop on leadership for MD/PhD students.Med Educ Online2011
20460648Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.Sci Signal2010
19222191Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.Biochemistry2009
18043707Heterotrimeric G protein activation by G-protein-coupled receptors.Nat Rev Mol Cell Biol2008
17463080Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.Proc Natl Acad Sci U S A2007
17854655How do receptors activate G proteins?Adv Protein Chem2007
16638972Direct modulation of phospholipase D activity by Gbetagamma.Mol Pharmacol2006
17053066Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway.Proc Natl Acad Sci U S A2006
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Collaborators

Heidi E Hamm
Co-authored papers 10
Stephen Y Chan
and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine
Co-authored papers 8
Jane A Leopold
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 7
Anita M Preininger
IBM Corporation
Co-authored papers 4
Alexander R Opotowsky
Heart Institute, Cincinnati Children's Hospital Medical Center
Co-authored papers 3
Sara O Vargas
Boston Children's Hospital
Co-authored papers 3
David R Ziehr
Brigham and Women's Hospital
Co-authored papers 2
Jorge Moscat
Co-authored papers 2
Magdi H Yacoub
Co-authored papers 2
Stephen W Waldo
Department of Veterans Affairs Clinical Assessment
Co-authored papers 2
Maria T Diaz-Meco
Co-authored papers 2
Mustafa Sahin
Harvard Medical School
Co-authored papers 2
Katherine A Cottrill
Emory University
Co-authored papers 2
Mohit Jain
Cumming School of Medicine, University of Calgary, 0 Hospital Drive NW
Co-authored papers 1
Jia-Ren Lin
Co-authored papers 1
David A Morrow
Brigham and Women's Hospital
Co-authored papers 1
Victoria N Parikh
Stanford University
Co-authored papers 1
Rebecca M Baron
Brigham and Women's Hospital
Co-authored papers 1
Paul Elbers
Amsterdam Institute for Infection and Immunity (AII), Vrije Universiteit
Co-authored papers 1
Judy E Garber
Dana-Farber Cancer Institute
Co-authored papers 1
Clary B Clish
Broad Institute of MIT and Harvard
Co-authored papers 1
Marc D Normandin
Massachusetts General Hospital, the Gordon Center for Medical Imaging
Co-authored papers 1
Christopher M Sauer
Amsterdam Institute for Infection and Immunity (AII), Vrije Universiteit
Co-authored papers 1
Alejandro Rodr??guez
Hospital Universitario de Tarragona Juan XXIII
Co-authored papers 1
Shi Huang
Vanderbilt University School of Medicine
Co-authored papers 1
Jamey D Young
Co-authored papers 1
J??rg Menche
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
Georges El Fakhri
Massachusetts General Hospital, the Gordon Center for Medical Imaging
Co-authored papers 1
David A Owens
Vanderbilt University Owen Graduate School of Management
Co-authored papers 1
Leo Anthony Celi
Harvard T.H. Chan School of Public Health, MIT
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Release 1.2