Author details

Full Name

David M Ornitz

Affiliation

ORCID

Career Start Year

1981

Papers

247

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37096042	Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.		2023
37591843	VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.	Signal Transduct Target Ther	2023
37688792	Multi-organ phenotypes in mice lacking latent TGFÎ² binding protein 2 (LTBP2).		2023
37270061	SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia.		2023
37204871	Characterization of a robust mouse model of heart failure with preserved ejection fraction.		2023
36734881	Targeted deletion of Fgf9 in tendon disrupts mineralization of the developing enthesis.		2023
35142107	New developments in the biology of fibroblast growth factors.		2022
36211556	Fibroblast growth factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury.	Front Cardiovasc Med	2022
35675358	Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis.	PLoS Pathogens	2022
36445537	FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells.	Cellular and Molecular Life Sciences	2022
34879776	Regenerative responses of rabbit corneal endothelial cells to stimulation by fibroblast growth factor 1 (FGF1) derivatives, TTHX1001 and TTHX1114.	Growth Factors	2021
34091985	Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments.	Developmental Dynamics	2021
33983905	ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control.	J Clin Invest	2021
34083250	Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer.	Cancer Research	2021
32735383	FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.	Developmental Dynamics	2021
34623323	Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension.	Journal of Clinical Investigation	2021
32664967	FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.	BMC Biol	2020
32127497	FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.	Science Signaling	2020
31830366	Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.	Journal of Cellular and Molecular Medicine	2020
31862844	Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis.	Development (Cambridge)	2020
32450229	Geminin is required for Hox gene regulation to pattern the developing limb.	Developmental Biology	2020
32492250	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	Developmental Dynamics	2020
31860803	FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury.	American Journal of Respiratory Cell and Molecular Biology	2020
33210059	Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly.	J Endocr Soc	2020
32907848	The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.	Development (Cambridge)	2020
31111569	Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei.	Journal of Neuroendocrinology	2019
31570588	Î²-Catenin is required for radial cell patterning and identity in the developing mouse cochlea.	Proceedings of the National Academy of Sciences of the United States of America	2019
30117627	Sculpting the skull through neurosensory epithelial-mesenchymal signaling.	Developmental Dynamics	2019
30595537	Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.	Dev Cell	2019
31290205	Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18).	Developmental Dynamics	2019
31090071	Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts.	Journal of Pathology	2019
30819894	Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.	Proceedings of the National Academy of Sciences of the United States of America	2019
31276493	Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.	PLoS Genetics	2019
31463736	Crouzon syndrome mouse model exhibits cartilage hyperproliferation and defective segmentation in the developing trachea.	Science China Life Sciences	2019
31449793	FGF2-induced STAT3 activation regulates pathologic neovascularization.	Exp Eye Res	2019
30903302	Diagnosis and Pathophysiological Mechanisms of Group 3 Hypoxia-Induced Pulmonary Hypertension.	Current Treatment Options in Cardiovascular Medicine	2019
30902253	Fibroblast growth factors in skeletal development.	Current Topics in Developmental Biology	2019
31206783	Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes.	Journal of Bone and Mineral Research	2019
29656749	Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms.	Lung Cancer	2018
29873400	Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.	J Pathol	2018
30100263	FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area.	Developmental Cell	2018
30283071	Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1).	Scientific Reports	2018
27987249	Achondroplasia: Development, pathogenesis, and therapy.	Developmental Dynamics	2017
28380381	FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms.		2017
28487375	Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.	Journal of Biological Chemistry	2017
28698625	Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.	Sci Rep	2017
27773526	An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.	J Pharm Sci	2016
28919847	Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.	Advanced Functional Materials	2016
26889602	Proteomic analysis of native cerebellar iFGF14 complexes.	Channels	2016
27019961	Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.	Journal of Pharmaceutical Sciences	2016