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Author Details

Sarah Alice Long
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
1999
62
28
PMIDPaper TitleJournal TitlePublished Year
36920087Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.Diabetes Care2023
37918404Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.Cell Rep Med2023
37758901Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.Commun Biol2023
37667106High proinsulin:C-peptide ratio identifies individuals with stage 2 type 1 diabetes at high risk for progression to clinical diagnosis and responses to teplizumab treatment.Diabetologia2023
37794253Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.Nat Med2023
37502867Latent EBV impairs immune cell signaling and enhances the efficacy of anti-CD3 mAb in Type 1 Diabetes.medRxiv2023
37432736Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes.JCI Insight2023
34593707Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.Crit Care Med2022
35608267Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness.Am J Physiol Lung Cell Mol Physiol2022
35980300Clinical and experimental treatment of type 1 diabetes.Clin Exp Immunol2022
35025103Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.Eur J Immunol2022
35020411Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.Sci Transl Med2022
33351781Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects.JCI Insight2021
33483981The many faces of islet antigen-specific CD8 T cells: clues to clinical outcome in type 1 diabetes.Immunol Cell Biol2021
33662335Combination therapy in recent-onset type 1 diabetes.Lancet Diabetes Endocrinol2021
33658358Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals.Sci Transl Med2021
35072168A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes.Immunother Adv2021
34747368IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.JCI Insight2021
34214479Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.Lancet Diabetes Endocrinol2021
33125521Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice.Diabetologia2021
33097590A distinct GM-CSF<sup>+</sup> T helper cell subset requires T-bet to adopt a T<sub>H</sub>1 phenotype and promote neuroinflammation.Sci Immunol2020
31815738Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.J Clin Invest2020
30830871B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.JCI Insight2019
31671072A composite immune signature parallels disease progression across T1D subjects.JCI Insight2019
31722988Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.J Immunol2019
31221801Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.Diabetes2019
31157632Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D.Curr Opin Endocrinol Diabetes Obes2019
30894366Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression.Diabetes2019
29769438Cytometry TOF identifies alveolar macrophage subtypes in acute respiratory distress syndrome.JCI Insight2018
29842945Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype.Clin Immunol2018
29473705Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics.Pediatr Diabetes2018
28844471Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.Cell Immunol2017
28645874Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.Clin Immunol2017
27629486Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.Sci Transl Med2016
28664195Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes.Sci Immunol2016
25634360Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.J Autoimmun2015
26249556Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies.J Cell Mol Med2015
26448755Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways.Int J Cell Biol2015
26606968Type 1 diabetes immunotherapy using polyclonal regulatory T cells.Sci Transl Med2015
26193635Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients.J Clin Invest2015
24576418Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance.Clin Immunol2014
23363979In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling.Sci Transl Med2013
24376757Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.PLoS One2013
23600824Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes.Clin Exp Immunol2013
23807601Intersection between genetic polymorphisms and immune deviation in type 1 diabetes.Curr Opin Endocrinol Diabetes Obes2013
23499139IL-2 therapy in type 1 diabetes: "Trials" and tribulations.Clin Immunol2013
22721971Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.Diabetes2012
21179116An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.Genes Immun2011
21865550Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells.J Immunol2011
21856944CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game.J Immunol2011
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Collaborators

Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 24
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 17
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Co-authored papers 12
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 11
Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 10
8Benaroya Research Institute
Co-authored papers 10
Yale University
Co-authored papers 9
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 7
The Henry Jackson Foundation.
Co-authored papers 5
University of California san francisco
Co-authored papers 5
Benaroya Research Institute at Virginia Mason
Co-authored papers 5
Clinical Trials Group
Co-authored papers 5
Co-authored papers 5
Benaroya Research Institute at Virginia Mason
Co-authored papers 3
College of Medicine, Diabetes Institute, University of Florida
Co-authored papers 3
Allergy and Clinical Immunology, University of California at Davis
Co-authored papers 3
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 3
Children's Hospital of Philadelphia
Co-authored papers 3
Center for Systems Immunology, Benaroya Research Institute Seattle
Co-authored papers 3
Nursing and Health SciencesMonash UniversityClaytonVictoriaAustralia.
Co-authored papers 2
Benaroya Research Institute at Virginia Mason
Co-authored papers 2
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Co-authored papers 2
Health Informatics Institute, University of South Florida
Co-authored papers 2
Center for Translational Research
Co-authored papers 2
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 2
University of California berkeley
Co-authored papers 2
Co-authored papers 2
University of Washington
Co-authored papers 2
Benaroya Research Institute
Co-authored papers 2