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Author Details

Judith Frydman
Stanford University
1990
152
67
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36603548Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein.Neuron2023
37487061High-resolution mapping reveals the mechanism and contribution of genome insertions and deletions to RNA virus evolution.Proc Natl Acad Sci U S A2023
37625406A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT.Mol Cell2023
37461541SARS-CoV-2 Nsp1 regulates translation start site fidelity to promote infection.bioRxiv2023
37016670A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle.bioRxiv2023
37116473Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.Cell2023
37081164Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear-vacuolar junctions and perinuclear ESCRT.Nat Cell Biol2023
37376634Novel Mode of nanoLuciferase Packaging in SARS-CoV-2 Virions and VLPs Provides Versatile Reporters for Virus Production.Viruses2023
37034684Proteostasis and lysosomal quality control deficits in Alzheimer's disease neurons.bioRxiv2023
35259016Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration.Proc Natl Acad Sci U S A2022
35472290Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes.Annu Rev Biomed Data Sci2022
35830852A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.Cell Chem Biol2022
36493755Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.Cell2022
36367941Fragment-based computational design of antibodies targeting structured epitopes.Sci Adv2022
35046576Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis.Nature2022
35000205Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.Ann N Y Acad Sci2022
34362932CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin.Nat Commun2021
33491648Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells.Elife2021
33836586Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network.Proc Natl Acad Sci U S A2021
34852237A defective viral genome strategy elicits broad protective immunity against respiratory viruses.Cell2021
34675396Author Correction: Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis.Nature2021
34408324Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis.Nature2021
34158536Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns.Sci Rep2021
34239038Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.Commun Biol2021
30858229Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay.Cold Spring Harb Perspect Biol2020
32019880Dynamics and clustering of IRE1α during ER stress.Proc Natl Acad Sci U S A2020
32042106REP-X: An Evolution-guided Strategy for the Rational Design of Cysteine-less Protein Variants.Sci Rep2020
33219289Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.Sci Rep2020
32814034Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells.Structure2020
32268122Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network.Mol Cell2020
30504455The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis.J Biol Chem2019
30149694Huntingtin's N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective.ACS Chem Neurosci2019
31400849Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT.Mol Cell2019
31371460Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy.Genes Dev2019
30955883The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.Cell2019
30982745Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.Mol Cell2019
30978594The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story.Curr Opin Struct Biol2019
30910025Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae.Methods Enzymol2019
30673613Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.Cell Rep2019
29531365The TRiC chaperonin controls reovirus replication through outer-capsid folding.Nat Microbiol2018
30204984Post-extubation non-invasive ventilation in the pediatric intensive care unit: a multicenter study.Arch Argent Pediatr2018
30429547Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control.Nature2018
30308158A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.Cell Host Microbe2018
29725062Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.Nat Commun2018
29565826Time-Resolved Measurement of the ATP-Dependent Motion of the Group II Chaperonin by Diffracted Electron Tracking.Int J Mol Sci2018
29590078Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.Science2018
28741612An information theoretic framework reveals a tunable allosteric network in group II chaperonins.Nat Struct Mol Biol2017
28489421Mechanisms and Functions of Spatial Protein Quality Control.Annu Rev Biochem2017
28085263Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.J Am Chem Soc2017
28293421Protein misfolding in neurodegenerative diseases: implications and strategies.Transl Neurodegener2017
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Collaborators

Wah Chiu
Stanford University
Co-authored papers 18
Raul Andino
University of California san francisco
Co-authored papers 13
Alexander Leitner
ETH Zurich
Co-authored papers 10
V??ronique Alban??se
Universite Paris Cite, CNRS, Institut Jacques Monod
Co-authored papers 9
Anne S Meyer
University of Rochester
Co-authored papers 8
Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 6
Steven J Ludtke
Baylor College of Medicine
Co-authored papers 6
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West China Hospital, Sichuan University
Co-authored papers 5
Yao Cong
University of Chinese Academy of Sciences
Co-authored papers 5
Thomas Walzthoeni
Institute for Computational Biology
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Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Michael Levitt
Stanford University
Co-authored papers 3
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Co-authored papers 3
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
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Grigore Pintilie
Stanford University
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Yu Xia
College of Information Engineering, Zhejiang University of Technology
Co-authored papers 3
Gunnar F Schr??der
Institute of Biological Information Processing (Structural Biochemistry)
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Paul Tempst
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Aaron D Gitler
Stanford University School of Medicine
Co-authored papers 2
Paul D Adams
Lawrence Berkeley National Laboratory
Co-authored papers 2
Christopher R Booth
3Gatan Inc.,Pleasanton,CA,USA.
Co-authored papers 2
Tony Wyss-Coray
Stanford University
Co-authored papers 2
Corie Y Ralston
Lawrence Berkeley National Laboratory
Co-authored papers 2
Hediye Erdjument-Bromage
Neuroscience Institute, NYU Grossman School of Medicine
Co-authored papers 2
Eliezer Masliah
National Institute On Aging
Co-authored papers 2
Matthew T Dougherty
Baylor College of Medicine
Co-authored papers 2
Hao Shao
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
Matthew L Baker
McGovern Medical School at the University of Texas Health Science Center
Co-authored papers 2
Mark Gerstein
Yale University
Co-authored papers 2
Eric B Dammer
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Co-authored papers 1
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