Author details

Full Name

David T Scadden

Affiliation

ORCID

Career Start Year

1984

Papers

391

H Index

111

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37530823	Health Consequences of Thymus Removal in Adults.		2023
36255703	Isolation of Thymus Stromal Cells from Human and Murine Tissue.	Methods in Molecular Biology	2023
37748049	Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody-drug conjugate.		2023
37595362	PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.	Blood	2023
37732224	CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer.		2023
37681409	Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo.		2023
37267513	Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors.	Blood	2023
37450380	The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression.		2023
37066307	Myelodysplastic syndromes disable human CD271+VCAM1+CD146+ niches supporting normal hematopoietic stem/progenitor cells.	bioRxiv	2023
36750562	Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses.		2023
36684088	Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration.		2023
34610101	Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.	Blood	2022
36180422	A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma.	Nature Communications	2022
35830837	Recent advances in "sickle and niche" research - Tribute to Dr. Paul S Frenette.	Stem Cell Reports	2022
35747128	Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.		2022
36129517	Sleep exerts lasting effects on hematopoietic stem cell function and diversity.	Journal of Experimental Medicine	2022
35793392	In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies.	Blood advances	2022
35352063	B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.	Nature Immunology	2022
36424441	Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging.	Nature Methods	2022
36382886	Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections.	Elife	2022
34758323	Chromatin-state barriers enforce an irreversible mammalian cell fate decision.	Cell Reports	2021
32387109	Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency.	J Allergy Clin Immunol	2021
33633351	Young haematopoietic stem cells are picky eaters.	Cell Research	2021
34103421	Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.	Science Signaling	2021
33770508	Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.		2021
33150374	Progression signature underlies clonal evolution and dissemination of multiple myeloma.	Blood	2021
33431855	Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.	Nat Commun	2021
34865700	What is the role of the bone marrow microenvironment in AML?	Best Practice and Research in Clinical Haematology	2021
34864816	Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation.	Blood Cancer Journal	2021
34403758	In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early.	Experimental Hematology	2021
34722818	Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.	Bio-protocol	2021
34719426	Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.	Cancer Cell	2021
34663922	Author Correction: An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.	Nature Biotechnology	2021
34551362	tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche.		2021
34939923	External signals regulate continuous transcriptional states in hematopoietic stem cells.	eLife	2021
32780848	Cell interactions in the bone marrow microenvironment affecting myeloid malignancies.	Blood advances	2020
31937942	A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia.	Nature Biomedical Engineering	2020
32226796	Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning.	Molecular Therapy - Methods and Clinical Development	2020
32103177	Lipid availability determines fate of skeletal progenitor cells via SOX9.	Nature	2020
32483373	C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.	Nature	2020
32458004	Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.	Blood	2020
32766876	Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations.	Blood	2020
32763164	Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.		2020
32877669	Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress.	Cell Rep	2020
32842144	VEGF-C protects the integrity of the bone marrow perivascular niche in mice.	Blood	2020
30880025	Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.		2019
31700184	Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.	Nature Medicine	2019
31765673	Metcalf Lecture Award: Applying niche biology to engineer T-cell regenerative therapies.	Experimental Hematology	2019
31809737	Identification of Functionally Distinct Mx1+Î±SMA+ Periosteal Skeletal Stem Cells.		2019
30335223	Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry.	Current Protocols in Cytometry	2019