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Author Details

Andrei Chabes
Umea University
1997
82
37
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36807798Quantitative Analysis of Nucleoside Triphosphate Pools in Mouse Muscle Using Hydrophilic Interaction Liquid Chromatography Coupled with Tandem Mass Spectrometry Detection.Methods Mol Biol2023
37481989Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɿ results in increased involvement of Pol δ on the leading strand.DNA Repair (Amst)2023
37548337NME6: ribonucleotide salvage sustains mitochondrial transcription.EMBO J2023
34850106Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples.Nucleic Acids Res2022
36476929dNTP concentrations do not increase in mammalian cells in response to DNA damage.Cell Metab2022
35017203Chl1 helicase controls replication fork progression by regulating dNTP pools.Life Sci Alliance2022
35038632Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex.DNA Repair (Amst)2022
32402273SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.Cell Rep2020
31647103Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.Nucleic Acids Res2020
32778836Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos.Nat Metab2020
32720483[SAMHD1 acts at stalled replication forks to prevent interferon induction].C R Biol2020
32187369High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase.Nucleic Acids Res2020
32169162Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication.Mol Cell2020
32513727Elimination of rNMPs from mitochondrial DNA has no effect on its stability.Proc Natl Acad Sci U S A2020
30698744The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.Nucleic Acids Res2019
31588022Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.Mol Cell2019
31300555<i>De novo</i> dNTP production is essential for normal postnatal murine heart development.J Biol Chem2019
31093968Ribonucleotides in mitochondrial DNA.FEBS Lett2019
30917156A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis.PLoS One2019
30462295A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance.Nucleic Acids Res2019
30670691A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.Nat Commun2019
29670289SAMHD1 acts at stalled replication forks to prevent interferon induction.Nature2018
30158111Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.EMBO J2018
30065069Rtt105 functions as a chaperone for replication protein A to preserve genome stability.EMBO J2018
30115745A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.Science2018
29899143Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.Genes Dev2018
29848621Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in <i>Saccharomyces cerevisiae</i>.G3 (Bethesda)2018
29554314Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.Nucleic Acids Res2018
29360860Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.PLoS Genet2018
28604743Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.Oncogene2017
28387227Corrigendum: Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins.Sci Rep2017
28180291Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.Nucleic Acids Res2017
28416670Alterations in cellular metabolism triggered by <i>URA7</i> or <i>GLN3</i> inactivation cause imbalanced dNTP pools and increased mutagenesis.Proc Natl Acad Sci U S A2017
29109257Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.Proc Natl Acad Sci U S A2017
29033319Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.Mol Cell2017
29069086Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.PLoS Genet2017
27085808The mutation spectrum in genomic late replication domains shapes mammalian GC content.Nucleic Acids Res2016
26609135Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.Nucleic Acids Res2016
27806303Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase.Cell Rep2016
27071091Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance.Proc Natl Acad Sci U S A2016
25751426Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.Nat Struct Mol Biol2015
26603472S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.Biol Open2015
25869206Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.Oncotarget2015
25916709Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.Methods Mol Biol2015
25827231Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.Proc Natl Acad Sci U S A2015
25827226dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Proc Natl Acad Sci U S A2015
24728996Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups.Nucleic Acids Res2014
25449133Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.Mol Cell2014
25474551Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity.PLoS Genet2014
25275495H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.PLoS Genet2014
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Collaborators

Sushma Sharma
Umea University
Co-authored papers 31
Rodney Rothstein
Columbia University Vagelos College of Physicians & Surgeons
Co-authored papers 4
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Memorial Sloan-Kettering Cancer Center
Co-authored papers 4
Zhiguo Zhang
Institute for Cancer Genetics, Columbia University Irving Medical Center
Co-authored papers 3
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German Cancer Research Center (DKFZ)
Co-authored papers 3
Junhong Han
West China Hospital, Sichuan University
Co-authored papers 3
Johan Trygg
Co-authored papers 2
Paul Russell
The Scripps Research Institute
Co-authored papers 2
Michael Chang
Columbia University Medical Center
Co-authored papers 2
Ian G Mills
Queen's University Belfast
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Gianrico Farrugia
Mayo Clinic Gastroenterology and Hepatology, Mayo Clinic
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Arancha S??nchez
The Scripps Research Institute
Co-authored papers 1
Haico van Attikum
Leiden University Medical Center
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MRC Weatherall Institute of Molecular Medicine, University of Oxford
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Prostate Cancer Research Center, Tampere University and Tays Cancer Center
Co-authored papers 1
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University of British Columbia
Co-authored papers 1
Sophie Rozenzhak
The Scripps Research Institute
Co-authored papers 1
Chad L Myers
University of Minnesota - Twin Cities
Co-authored papers 1
Amandine Batt??
Center for Integrative Genomics, University of Lausanne
Co-authored papers 1
Assen Roguev
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 1
Alfonso Urbanucci
Northwestern University Feinberg School of Medicine Chicago
Co-authored papers 1
Amos Tanay
Weizmann Institute of Science
Co-authored papers 1
John R Yates
TheScripps Research Institute
Co-authored papers 1
Marcus B Smolka
Weill Institute for Cell and Molecular Biology, Cornell University
Co-authored papers 1
Shibai Li
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