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Author Details

Ralph A DeFronzo
1967
717
156
PMIDPaper TitleJournal TitlePublished Year
37034666Insulinotropic effect of endogenous incretins is greater after gastric bypass than sleeve gastrectomy despite diminished beta-cell sensitivity to plasma incretins.2023
36204991Pioglitazone reduces epicardial fat and improves diastolic function in patients with type 2 diabetes.Diabetes, Obesity and Metabolism2023
37853989Differential effect of gastric bypass versus sleeve gastrectomy on insulinotropic action of endogenous incretins.2023
37790563Contribution of endogenous glucagon-like peptide 1 to prandial counterregulatory responses to hypoglycemia after bariatric surgery.2023
37961500GLP-1 enhances beta-cell response to protein ingestion and bariatric surgery amplifies it.2023
37467435Bariatric Surgery Alters the Postprandial Recovery From Hypoglycemia, Mediated by Cholinergic Signal.2023
36947093Fasting Hyperinsulinemia and Obesity: Cause or Effect.2023
36746320Chronic physiologic hyperglycemia impairs insulin-mediated suppression of plasma glucagon concentration in healthy humans.2023
36857415Distinct Mechanisms Responsible for the Increase in Glucose Production and Ketone Formation Caused by Empagliflozin in T2DM Patients.Diabetes Care2023
36988137Plasma insulin is required for the increase in plasma angiopoietin-like protein 8 in response to nutrient ingestion.Diabetes Metab Res Rev2023
36669322Early intervention and intensive management of patients with diabetes, cardiorenal, and metabolic diseases.J Diabetes Complications2023
37481263Emergence of a New Gluco-Regulatory Mechanism for Glycemic Control with Dapagliflozin/Exenatide Therapy in Type 2 Diabetes.2023
35066003Insulin: The master regulator of glucose metabolism.Metabolism: Clinical and Experimental2022
35971756Are angiotensin-converting enzyme inhibitors/angiotensin receptor blockers associated with reduced severe acute respiratory syndrome coronavirus 2 infections and improved outcomes, and does race matter?Diabetes, Obesity and Metabolism2022
35390439Prandial hepatic glucose production during hypoglycemia is altered after gastric bypass surgery and sleeve gastrectomy.Metabolism: Clinical and Experimental2022
35963508American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocr Pract2022
35581905Type 2 diabetes subgroups and response to glucose-lowering therapy: Results from the EDICT and Qatar studies.Diabetes, Obesity and Metabolism2022
35887007Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions.International Journal of Molecular Sciences2022
36012132Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects.International Journal of Molecular Sciences2022
35552423Effects of Sustained Hyperglycemia on Skeletal Muscle Lipids in Healthy Subjects.Journal of Clinical Endocrinology and Metabolism2022
36204553Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican- American adults: Results from the genetics of brain structure image archive.Frontiers in Aging Neuroscience2022
35723225FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes.American Journal of Physiology - Endocrinology and Metabolism2022
35302284Modifying chronic kidney disease progression with the mineralocorticoid receptor antagonist finerenone in patients with type 2 diabetes.Diabetes, Obesity and Metabolism2022
34922811DCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases.J Diabetes Complications2022
35253334Efficacy of lower doses of pioglitazone after stroke or transient ischaemic attack in patients with insulin resistance.Diabetes Obes Metab2022
35235659Dapagliflozin Impairs the Suppression of Endogenous Glucose Production in Type 2 Diabetes Following Oral Glucose.Diabetes Care2022
35014145Combination therapy with pioglitazone/exenatide/metformin reduces the prevalence of hepatic fibrosis and steatosis: The efficacy and durability of initial combination therapy for type 2 diabetes (EDICT).Diabetes, Obesity and Metabolism2022
34362813New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms.Diabetes Care2021
36654276Chiglitazar: a novel pan-PPAR agonist.2021
33972318Comment on Piccinini and Bergman. The Measurement of Insulin Clearance. Diabetes Care 2020;43:2296-2302.Diabetes Care2021
33910583From glucose lowering agents to disease/diabetes modifying drugs: a "SIMPLE" approach for the treatment of type 2 diabetes.Cardiovascular Diabetology2021
33479282Further evidence supporting a potential role for ADH1B in obesity.Sci Rep2021
33852204Insulin secretion is a strong predictor for need of insulin therapy in patients with new-onset diabetes and HbA1c of more than 10%: A post hoc analysis of the EDICT study.Diabetes, Obesity and Metabolism2021
33741697Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults: A Meta-analysis.Diabetes Care2021
34162682Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration.Diabetes2021
34002953Insulin resistance limits corneal nerve regeneration in patients with typeâ¿¿2 diabetes undergoing intensive glycemic control.Journal of Diabetes Investigation2021
33524152Impaired Suppression of Glucagon in Obese Subjects Parallels Decline in Insulin Sensitivity and Beta-Cell Function.Journal of Clinical Endocrinology and Metabolism2021
33522574Insulin Resistance and Hyperinsulinemia: the Egg and the Chicken.Journal of Clinical Endocrinology and Metabolism2021
33931489Erratum. Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults: A Meta-analysis. Diabetes Care 2021;44:1062-1069.Diabetes Care2021
33714226Painful diabetic neuropathy is associated with increased nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control.Journal of Diabetes Investigation2021
33441626Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children.Scientific Reports2021
34343296Insulin Secretion Predicts the Response to Antidiabetic Therapy in Patients With New-onset Diabetes.Journal of Clinical Endocrinology and Metabolism2021
34185956Ultrasound-Targeted Microbubble Destruction Mediates Gene Transfection for Beta-Cell Regeneration and Glucose Regulation.Small2021
33547417Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.Nature Reviews Nephrology2021
33033064Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects.2021
33137378Pioglitazone corrects dysregulation of skeletal muscle mitochondrial proteins involved in ATP synthesis in type 2 diabetes.Metabolism: Clinical and Experimental2021
33077684Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance.2021
33334808Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort.Diabetes Care2021
33273042Durability of Triple Combination Therapy Versus Stepwise Addition Therapy in Patients With New-Onset T2DM: 3-Year Follow-up of EDICT.Diabetes Care2021
33400689Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.JCI Insight2021
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