Skip to Main Content

Author Details

Svend Peter Klinken
Harry Perkins Institute of Medical Research
1977
83
31
PMIDPaper TitleJournal TitlePublished Year
28850106FANTOM5 CAGE profiles of human and mouse samples.Sci Data2017
28829439An integrated expression atlas of miRNAs and their promoters in human and mouse.Nat Biotechnol2017
25678556Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.Science2015
24670764A promoter-level mammalian expression atlas.Nature2014
24552351Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival.Biochem J2014
23692855Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.Blood2013
19064729Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.Blood2009
18984583Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.J Biol Chem2009
18063753Hls5 regulated erythroid differentiation by modulating GATA-1 activity.Blood2008
18203951Erythroid defects in TRalpha-/- mice.Blood2008
16393697Cross-regulation of JAK and Src kinases.Growth Factors2006
17008314Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.J Biol Chem2006
16920712Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.J Biol Chem2006
15516974Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.Oncogene2005
15878399Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.Biochim Biophys Acta2005
14662771HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.J Biol Chem2004
15230344New insights into the regulation of erythroid cells.IUBMB Life2004
15122318Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation.Oncogene2004
12761492Differential regulation of SOCS genes in normal and transformed erythroid cells.Oncogene2003
12176995MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.J Biol Chem2002
12181065Enforced expression of HOX11 is associated with an immature phenotype in J2E erythroid cells.Br J Haematol2002
11544260Thyroid hormone receptor-interacting protein 1 modulates cytokine and nuclear hormone signaling in erythroid cells.J Biol Chem2001
11289114Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn.Cancer Res2001
11716471Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells.Arch Biochem Biophys2001
10736566Karyotypic abnormalities associated with haemopoietic lineage switching are not linked with mutations to p53.Int J Biochem Cell Biol2000
10842186Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells.J Biol Chem2000
10713104HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells.J Biol Chem2000
10702804Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo.Oncogene2000
10508919A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit.FEBS Lett1999
10582350Plasticity in the haemopoietic system.Int J Biochem Cell Biol1999
10582333The erythropoietin receptor.Int J Biochem Cell Biol1999
10582330Regulation of hemopoietic system.Int J Biochem Cell Biol1999
10495960Erythropoietin and erythropoietin receptor.Growth Factors1999
10523300HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.EMBO J1999
9726989Transcription factor erythroid Krüppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation.J Biol Chem1998
9012779Method for measuring a comprehensive energy budget in a proliferating cell system over multiple cell cycles.J Cell Physiol1997
16465216Prevention of apoptosis in J2E erythroid cells by erythropoietin: involvement of JAK2 but not MAP kinases.Cell Death Differ1997
9130706Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells.EMBO J1997
9178772Increased transcription of the E mu-myc transgene and mRNA stabilisation produce only a modest elevation in Myc protein.Oncogene1997
9363756Complex regulation of transferrin receptors during erythropoietin-induced differentiation of J2E erythroid cells--elevated transcription and mRNA stabilisation produce only a modest rise in protein content.Eur J Biochem1997
9428699Haemoglobin synthesis in erythropoietin-stimulated J2E cells does not require increased numbers of transferrin receptors.Eur J Biochem1997
8631947Disrupted signaling in a mutant J2E cell line that shows enhanced viability, but does not proliferate or differentiate, with erythropoietin.J Biol Chem1996
9052992Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells.Cell Growth Differ1996
8729004Truncated erythropoietin receptor in a murine erythroleukemia cell line.Int J Biochem Cell Biol1996
8645341Inhibition of proliferation but not erythroid differentiation of J2E cells by rapamycin.Biochem Pharmacol1996
7542230Diaminofluorene is more sensitive than benzidine for detecting hemoglobin in erythropoietin responsive J2E cells.Hemoglobin1995
8528938Interferon-alpha inhibits erythropoietin-induced proliferation, but not differentiation, and restricts erythroleukemia development.J Interferon Cytokine Res1995
7794811Emergence of myeloid cells from cultures of J2E erythroid cells is linked with karyotypic abnormalities.Cell Growth Differ1995
7794810Erythropoietin exerts transcriptional and translational control over globin synthesis in J2E cells.Cell Growth Differ1995
7769854A rapid fatal erythroleukemia caused by J2E cells can be treated ex vivo with erythropoietin.Leukemia1995
  • 1 - 50 of 83

Recommended Authors

Boston Children's Hospital, Harvard Medical School
Career Start Year 2006
Number of shared co-authors 0
MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital
Career Start Year 2000
Number of shared co-authors 0
Heidelberg University
Career Start Year 2000
Number of shared co-authors 0
Children's Hospital of Philadelphia
Career Start Year 1999
Number of shared co-authors 1
University of Texas Southwestern Medical Center
Career Start Year 1997
Number of shared co-authors 0
RIKEN BioResource Research Center
Career Start Year 1992
Number of shared co-authors 3
Center for Cancer Innovation, University of Washington
Career Start Year 1991
Number of shared co-authors 0
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Career Start Year 1990
Number of shared co-authors 0
The Leucegene Project at Institute for Research in Immunology and Cancer.
Career Start Year 1989
Number of shared co-authors 0
Universite de Montreal, Institute for Research in Immunology and Cancer
Career Start Year 1988
Number of shared co-authors 1
Center for Molecular Medicine, University of Georgia
Career Start Year 1986
Number of shared co-authors 0
Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University
Career Start Year 1981
Number of shared co-authors 1
Advanced Research Institute, Tokyo Medical and Dental University
Career Start Year 1981
Number of shared co-authors 54
Johns Hopkins University School of Medicine
Career Start Year 1980
Number of shared co-authors 0
Hollings Cancer Center, Medical University of South Carolina
Career Start Year 1979
Number of shared co-authors 3
University of Minnesota
Career Start Year 1978
Number of shared co-authors 0
St. Jude Children's Research Hospital
Career Start Year 1977
Number of shared co-authors 2
Center for Stem Cell Biology & Regenerative Medicine and.
Career Start Year 1976
Number of shared co-authors 1
Harvard Stem Cell Institute, Harvard Medical School
Career Start Year 1975
Number of shared co-authors 2
Princess Margaret Cancer Centre, University Health Network
Career Start Year 1975
Number of shared co-authors 0
Dana-Farber Cancer Institute
Career Start Year 1975
Number of shared co-authors 5
University of Rochester Medical Center, Wilmot Cancer Institute
Career Start Year 1974
Number of shared co-authors 0
National Heart Lung and Blood Institute Division of Intramural Research
Career Start Year 1972
Number of shared co-authors 0
University of California los angeles
Career Start Year 1972
Number of shared co-authors 2
Princess Margaret Cancer Centre, University Health Network
Career Start Year 1970
Number of shared co-authors 5
St. Jude Children's Research Hospital
Career Start Year 1968
Number of shared co-authors 0
The Johns Hopkins University School of Medicine
Career Start Year 1968
Number of shared co-authors 0
Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School
Career Start Year 1967
Number of shared co-authors 6
Knight Cancer Institute, Oregon Health and Science University
Career Start Year 1966
Number of shared co-authors 0
University of Washington
Career Start Year 1962
Number of shared co-authors 2

Collaborators

Harry Perkins Institute of Medical Research
Co-authored papers 9
International Institute of Molecular and Cell Biology in Warsaw
Co-authored papers 4
University of British Columbia and BC Children's Hospital
Co-authored papers 4
Center for Integrative Medical Sciences
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences (IMS)
Co-authored papers 4
Institute for Protein Research, Osaka University
Co-authored papers 4
Institute of Industrial Science, The University of Tokyo
Co-authored papers 4
Center for Integrative Medical Sciences
Co-authored papers 4
Karolinska Institutet
Co-authored papers 4
The University of Melbourne
Co-authored papers 4
Ellen and Ronald Caplan Cancer Center, The Wistar Institute
Co-authored papers 4
Institute of Industrial Science, The University of Tokyo
Co-authored papers 4
Karolinska Institutet at Karolinska Hospital-Huddinge
Co-authored papers 4
Telethon Kids Institute, University of Western Australia
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences
Co-authored papers 4
Cerevance Ltd
Co-authored papers 4
Mater Research Institute-University of Queensland, Translational Research Institute
Co-authored papers 4
RIKEN Center for Life Science Technologies
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences
Co-authored papers 4
Institute of Industrial Science, The University of Tokyo
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences
Co-authored papers 4
RIKEN Center for Integrative Medical Sciences
Co-authored papers 4
University of British Columbia
Co-authored papers 4
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 4
Child and Family Research Institute, University of British Columbia
Co-authored papers 4
Kyungpook National University, Kyungpook National University Hospital
Co-authored papers 3
Tohoku University Graduate School of Medicine
Co-authored papers 3
Leiden University Medical Center
Co-authored papers 3