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Author Details

Pritam Das
Institute of Medical Sciences, Banaras Hindu University
1998
63
39
PMIDPaper TitleJournal TitlePublished Year
35846360Vascular Endothelial Growth Factor Receptor-1 Modulates Hypoxia-Mediated Endothelial Senescence and Cellular Membrane Stiffness <i>via</i> YAP-1 Pathways.Front Cell Dev Biol2022
30506121L-type calcium channel blockers and a symptom complex mimicking de Melo-Souza's syndrome.Neurol Sci2019
31942518A case of rapidly progressive dementia: A diagnosis not to be missed.Aging Med (Milton)2019
31513781Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.Biochim Biophys Acta Biomembr2019
30576228VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells.FASEB J2019
29626114Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice.J Exp Med2018
30090985Morvan's syndrome-is a pathogen behind the curtain?Neurol Sci2018
28919107Combination of Aβ Suppression and Innate Immune Activation in the Brain Significantly Attenuates Amyloid Plaque Deposition.Am J Pathol2017
29161341Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease.Brain2017
25619653IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.Neuron2015
26374899Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).J Biol Chem2015
26447481Altered Innate Immune and Glial Cell Responses to Inflammatory Stimuli in Amyloid Precursor Protein Knockout Mice.PLoS One2015
26111938Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.J Neurochem2015
24625695Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease.Brain2014
24623762Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.J Neurosci2014
23532086TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure.J Cereb Blood Flow Metab2013
22621179Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.Alzheimers Res Ther2012
23046583Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Mol Neurodegener2012
22697412Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.Alzheimers Res Ther2012
22709352Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult.Mol Neurodegener2012
22892055Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.Mol Neurodegener2012
22886847Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.Cardiovasc Res2012
22838967Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.Mol Neurodegener2012
21411653Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy.J Neurosci2011
22197934Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.Nat Genet2011
21868378Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.J Biol Chem2011
21572432Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.Nat Neurosci2011
21324189Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo.Mol Neurodegener2011
19825975Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.FASEB J2010
21123562Reduced Alzheimer's disease ÿ-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.J Neurosci2010
20368278IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.J Immunol2010
19275635Quantitative and mechanistic studies of Abeta immunotherapy.CNS Neurol Disord Drug Targets2009
19419556Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.Mol Neurodegener2009
19320056Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.Neurobiol Dis2009
18272491Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.Proc Natl Acad Sci U S A2008
18550850Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.Blood2008
18647832A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.Proc Natl Acad Sci U S A2008
17827153Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.J Biol Chem2007
17897827A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.Bioorg Med Chem Lett2007
17559680Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.Mol Neurodegener2007
16341263Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.J Clin Invest2006
17108166Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.J Neurosci2006
17068112Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.FASEB J2006
17080189Dysfunction of TGF-beta signaling in Alzheimer's disease.J Clin Invest2006
16872492Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.J Neuroinflammation2006
16460841Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.Vaccine2006
16672644Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.J Neurosci2006
15708450Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.Neurobiol Aging2005
15834426Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.Nat Med2005
16039562Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.Neuron2005
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Collaborators

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Mayo Clinic Jacksonville
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Co-authored papers 10
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Yona Levites
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College of Medicine, University of Florida
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University of Antwerp
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Co-authored papers 1
Susan G Hilsenbeck
Co-authored papers 1
James A Eddy
Benaroya Research Institute at Virginia Mason, Institute for Systems Biology, Sage Bionetworks, University of Illinois at Urbana-Champaign
Co-authored papers 1
Hui Zheng
Baylor College of Medicine
Co-authored papers 1
Tong Li
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Bradley F Boeve
Mayo Clinic Rochester
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Amanda N Sacino
Johns Hopkins University School of Medicine
Co-authored papers 1
Eliezer Masliah
National Institute On Aging
Co-authored papers 1
Bradley T Hyman
Massachusetts General Hospital
Co-authored papers 1
NiCole A Finch
Mayo Clinic
Co-authored papers 1
Amanda J Roberts
The Scripps Research Institute
Co-authored papers 1
Charles G Eberhart
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Release 1.2