| 36928661 | Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. | Nucleic Acids Res | 2023 |
| 37847590 | Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages. | Cell Rep | 2023 |
| 37697435 | RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. | Nucleic Acids Res | 2023 |
| 37883228 | Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages. | Cell Rep | 2023 |
| 35483781 | Emerging roles of DNA topoisomerases in the regulation of R-loops. | Mutat Res Genet Toxicol Environ Mutagen | 2022 |
| 35668135 | The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness. | Nat Cell Biol | 2022 |
| 35393420 | Modification of BRCA1-associated breast cancer risk by HMMR overexpression. | Nat Commun | 2022 |
| 34196309 | Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. | J Clin Invest | 2021 |
| 33716297 | Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand. | Oncogene | 2021 |
| 33529165 | RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. | J Clin Invest | 2021 |
| 35008272 | <i>BRCA1</i> and Metastasis: Outcome of Defective DNA Repair. | Cancers (Basel) | 2021 |
| 34378323 | Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis. | EMBO Mol Med | 2021 |
| 32553156 | LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction. | Cell Rep | 2020 |
| 31819256 | Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. | Nat Immunol | 2020 |
| 32622267 | Immune Cell Associations with Cancer Risk. | iScience | 2020 |
| 32669707 | Nucleolar RNA polymerase II drives ribosome biogenesis. | Nature | 2020 |
| 29884901 | Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia. | Leukemia | 2019 |
| 30222135 | Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. | J Clin Invest | 2018 |
| 30181240 | The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. | Sci Signal | 2018 |
| 29988126 | Reducing protein oxidation reverses lung fibrosis. | Nat Med | 2018 |
| 26876210 | Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. | Oncogene | 2016 |
| 27558965 | RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. | Nat Commun | 2016 |
| 27523270 | The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis. | Immunity | 2016 |
| 24858046 | Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression. | Oncogene | 2015 |
| 24442508 | The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets. | Diabetologia | 2014 |
| 25349431 | DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. | Proc Natl Acad Sci U S A | 2014 |
| 24275659 | The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival. | J Biol Chem | 2014 |
| 23287466 | From photomorphogenesis to cancer: a CSN journey. | Cell Cycle | 2013 |
| 24360964 | LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. | Cell Rep | 2013 |
| 24324146 | RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. | Proc Natl Acad Sci U S A | 2013 |
| 24244021 | AID and caspase 8 shape the germinal center response through apoptosis. | J Immunol | 2013 |
| 23966173 | Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation. | Cell Cycle | 2013 |
| 23972991 | RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. | Cell Rep | 2013 |
| 23681708 | Systemic ceramide accumulation leads to severe and varied pathological consequences. | EMBO Mol Med | 2013 |
| 23449389 | The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. | Cell Death Differ | 2013 |
| 23382699 | Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. | PLoS Genet | 2013 |
| 23536557 | Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis. | Cancer Res | 2013 |
| 22343728 | Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis. | Blood | 2012 |
| 21368762 | RIP3 mediates the embryonic lethality of caspase-8-deficient mice. | Nature | 2011 |
| 22006951 | Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. | J Cell Biol | 2011 |
| 22125490 | Role of Pirh2 in mediating the regulation of p53 and c-Myc. | PLoS Genet | 2011 |
| 21791603 | Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. | Mol Cell Biol | 2011 |
| 21957448 | Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. | PLoS One | 2011 |
| 21625617 | Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. | PLoS Genet | 2011 |
| 21552324 | Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. | PLoS Genet | 2011 |
| 21368763 | Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. | Nature | 2011 |
| 20385750 | Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. | J Exp Med | 2010 |
| 21054854 | DNA double-strand break signaling and human disorders. | Genome Integr | 2010 |
| 20696928 | Dysregulation of the mevalonate pathway promotes transformation. | Proc Natl Acad Sci U S A | 2010 |
| 20678251 | Genome Integrity - a new open access journal. | Genome Integr | 2010 |