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Author Details

Razqallah Hakem
Princess Margaret Cancer Centre, University Health Network, University of Toronto
1987
103
52
PMIDPaper TitleJournal TitlePublished Year
36928661Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.Nucleic Acids Res2023
37847590Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.Cell Rep2023
37697435RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.Nucleic Acids Res2023
37883228Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.Cell Rep2023
35483781Emerging roles of DNA topoisomerases in the regulation of R-loops.Mutat Res Genet Toxicol Environ Mutagen2022
35668135The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.Nat Cell Biol2022
35393420Modification of BRCA1-associated breast cancer risk by HMMR overexpression.Nat Commun2022
34196309Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.J Clin Invest2021
33716297Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand.Oncogene2021
33529165RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.J Clin Invest2021
35008272<i>BRCA1</i> and Metastasis: Outcome of Defective DNA Repair.Cancers (Basel)2021
34378323Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis.EMBO Mol Med2021
32553156LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction.Cell Rep2020
31819256Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.Nat Immunol2020
32622267Immune Cell Associations with Cancer Risk.iScience2020
32669707Nucleolar RNA polymerase II drives ribosome biogenesis.Nature2020
29884901Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia.Leukemia2019
30222135Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.J Clin Invest2018
30181240The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.Sci Signal2018
29988126Reducing protein oxidation reverses lung fibrosis.Nat Med2018
26876210Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.Oncogene2016
27558965RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.Nat Commun2016
27523270The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.Immunity2016
24858046Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.Oncogene2015
24442508The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.Diabetologia2014
25349431DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.Proc Natl Acad Sci U S A2014
24275659The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.J Biol Chem2014
23287466From photomorphogenesis to cancer: a CSN journey.Cell Cycle2013
24360964LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.Cell Rep2013
24324146RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.Proc Natl Acad Sci U S A2013
24244021AID and caspase 8 shape the germinal center response through apoptosis.J Immunol2013
23966173Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation.Cell Cycle2013
23972991RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation.Cell Rep2013
23681708Systemic ceramide accumulation leads to severe and varied pathological consequences.EMBO Mol Med2013
23449389The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.Cell Death Differ2013
23382699Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.PLoS Genet2013
23536557Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.Cancer Res2013
22343728Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.Blood2012
21368762RIP3 mediates the embryonic lethality of caspase-8-deficient mice.Nature2011
22006951Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.J Cell Biol2011
22125490Role of Pirh2 in mediating the regulation of p53 and c-Myc.PLoS Genet2011
21791603Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis.Mol Cell Biol2011
21957448Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.PLoS One2011
21625617Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.PLoS Genet2011
21552324Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.PLoS Genet2011
21368763Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.Nature2011
20385750Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.J Exp Med2010
21054854DNA double-strand break signaling and human disorders.Genome Integr2010
20696928Dysregulation of the mevalonate pathway promotes transformation.Proc Natl Acad Sci U S A2010
20678251Genome Integrity - a new open access journal.Genome Integr2010
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Collaborators

Princess Margaret Cancer Centre, University Health Network
Co-authored papers 33
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 26
Ontario Tech University
Co-authored papers 16
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 11
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 9
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
Co-authored papers 8
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 7
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 7
University of Sao Paulo
Co-authored papers 7
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 4
Schroeder Arthritis Institute
Co-authored papers 4
University of Toronto
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
University of Toronto
Co-authored papers 3
University Health Network, University of Toronto
Co-authored papers 3
University of Toronto
Co-authored papers 3
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 2
Division of Clinical Studies, The Institute of Cancer Research
Co-authored papers 2
QIMR Berghofer Medical Research Institute
Co-authored papers 2
Children's Hospital Research Foundation
Co-authored papers 2
University of California los angeles
Co-authored papers 2
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 2
University of California San Diego
Co-authored papers 2
University of Ottawa
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
QIMR Berghofer Medical Research Institute
Co-authored papers 2
University of California, Los Angeles (university of california los angeles)
Co-authored papers 2
University Health Network
Co-authored papers 2