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Author Details

Brian Van Ness
University of Minnesota
1978
144
46
PMIDPaper TitleJournal TitlePublished Year
37217482Mass Cytometry reveals unique phenotypic patterns associated with subclonal diversity and outcomes in multiple myeloma.Blood Cancer J2023
35195258Understanding Drug Sensitivity and Tackling Resistance in Cancer.Cancer Res2022
35646666Single-Cell Proteomics and Tumor RNAseq Identify Novel Pathways Associated With Clofazimine Sensitivity in PI- and IMiD- Resistant Myeloma, and Putative Stem-Like Cells.Front Oncol2022
35853457Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.Cell Chem Biol2022
35264575secDrug: a pipeline to discover novel drug combinations to kill drug-resistant multiple myeloma cells using a greedy set cover algorithm and single-cell multi-omics.Blood Cancer J2022
34137665Pharmacogenomics education, research and clinical implementation in the state of Minnesota.Pharmacogenomics2021
32724061In vitro and ex vivo gene expression profiling reveals differential kinetic response of HSPs and UPR genes is associated with PI resistance in multiple myeloma.Blood Cancer J2020
30607001Molecular signatures of multiple myeloma progression through single cell RNA-Seq.Blood Cancer J2019
31537791Discovering genetic interactions bridging pathways in genome-wide association studies.Nat Commun2019
31111659Identification of a de novo FOXP1 mutation and incidental discovery of inherited genetic variants contributing to a case of autism spectrum disorder and epilepsy.Mol Genet Genomic Med2019
30683909The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies.Leukemia2019
29774113EZH2 inhibitors sensitize myeloma cell lines to panobinostat resulting in unique combinatorial transcriptomic changes.Oncotarget2018
30008546Pragmatic Tools for Sharing Genomic Research Results with the Relatives of Living and Deceased Research Participants.J Law Med Ethics2018
27981867Phenotypic and functional characterization of a bortezomib-resistant multiple myeloma cell line by flow and mass cytometry.Leuk Lymphoma2017
28415782Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells.Oncotarget2017
29242603Development of expression-based biomarkers of Dasatinib response in hematologic malignancies.Blood Cancer J2017
28665416A gene expression signature distinguishes innate response and resistance to proteasome inhibitors in multiple myeloma.Blood Cancer J2017
26001594Applications and limitations in translating genomics to clinical practice.Transl Res2016
28361099A de novo splice site mutation in EHMT1 resulting in Kleefstra syndrome with pharmacogenomics screening and behavior therapy for regressive behaviors.Mol Genet Genomic Med2016
26422532Risk of multiple myeloma in a case-spouse study.Leuk Lymphoma2016
27239040PIAS1 Promotes Lymphomagenesis through MYC Upregulation.Cell Rep2016
27242896Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.Front Genet2016
26710886Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors.Leukemia2016
26479555Returning a Research Participant's Genomic Results to Relatives: Analysis and Recommendations.J Law Med Ethics2015
26479561Returning a Research Participant's Genomic Results to Relatives: Perspectives from Managers of Two Distinct Research Biobanks.J Law Med Ethics2015
23734619Stabilization of activation induced cytidine deaminase by bortezomib does not confer increased drug target mutation frequency.Leuk Lymphoma2014
25368671Utilization of translational bioinformatics to identify novel biomarkers of bortezomib resistance in multiple myeloma.J Cancer2014
25005244High-throughput drug screening identifies compounds and molecular strategies for targeting proteasome inhibitor-resistant multiple myeloma.Leukemia2014
23536725Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model.Mol Cancer Ther2013
24204892Bortezomib resistance can be reversed by induced expression of plasma cell maturation markers in a mouse in vitro model of multiple myeloma.PLoS One2013
23728080Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomib.Leukemia2013
22120021Targeted overexpression of an activated N-ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia.Exp Hematol2012
22536319High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions.PLoS One2012
22436882Managing incidental findings and research results in genomic research involving biobanks and archived data sets.Genet Med2012
22382801Mapping the inputs, analyses, and outputs of biobank research systems to identify sources of incidental findings and individual research results for potential return to participants.Genet Med2012
22382800Return of individual research results and incidental findings in the clinical trials cooperative group setting.Genet Med2012
20488540Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis.Leuk Res2011
21903769Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies.Clin Cancer Res2011
21245421Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma.J Clin Oncol2011
21532841Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk.Int J Mol Epidemiol Genet2010
19798094International Myeloma Working Group molecular classification of multiple myeloma: spotlight review.Leukemia2009
19657367Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.Leukemia2009
18547191Managing incidental findings in human subjects research: analysis and recommendations.J Law Med Ethics2008
18778477Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.BMC Med2008
18805967Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping.Blood2008
19017943Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors.J Immunol2008
18528420Clinical and biological significance of RAS mutations in multiple myeloma.Leukemia2008
18547197Genomic research and incidental findings.J Law Med Ethics2008
16840723Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications.Blood2007
17483317A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma.Cancer Res2007
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Collaborators

Co-authored papers 12
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Law School and Medical School, University of Minnesota
Co-authored papers 6
University of Minnesota - Twin Cities
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University of Washington School of Medicine.
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University of Minnesota
Co-authored papers 4
Mayo Clinic
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University of California-San Francisco.
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Brigham and Women's Hospital, Broad Institute Ariadne Labs and Harvard Medical School
Co-authored papers 3
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Center for Biomedical Ethics and Society, Vanderbilt University Medical Center
Co-authored papers 3
Co-authored papers 2
Center for Bioethics & Health Law, University of Pittsburgh
Co-authored papers 2
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Co-authored papers 2
University of Minnesota
Co-authored papers 2
Harvard Medical School
Co-authored papers 2
Co-authored papers 2
Center for Biomedical Ethics, Stanford University School of Medicine
Co-authored papers 2
Mayo Clinic
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University of British Columbia.
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Berman Institute of Bioethics, Johns Hopkins University
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University of Minnesota
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University of Minnesota
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Mayo Clinic
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