Author details

Full Name

Frederick P Roth

Affiliation

University of Toronto

ORCID

Career Start Year

1998

Papers

158

H Index

Expertise

CM4AI Collaborator

Prashant Mali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36217029	A proteome-scale map of the SARS-CoV-2-human contactome.	Nat Biotechnol	2023
37478847	Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens.	Mol Cell	2023
37729906	Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.	Am J Hum Genet	2023
37394429	An Atlas of Variant Effects to understand the genome at nucleotide resolution.	Genome Biol	2023
37061542	Next-generation large-scale binary protein interaction network for Drosophila melanogaster.	Nat Commun	2023
37081510	satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect.	Genome Biol	2023
37267226	A resource of human coronavirus protein-coding sequences in a flexible, multipurpose Gateway Entry clone collection.	G3 (Bethesda)	2023
37426450	Minimum information and guidelines for reporting a Multiplexed Assay of Variant Effect.	ArXiv	2023
37292969	Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.	bioRxiv	2023
36716194	Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest.	Circ Genom Precis Med	2023
36798224	Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation.	bioRxiv	2023
36732511	Author Correction: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	Nat Commun	2023
36865234	Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic libraries.	bioRxiv	2023
36055970	Scalable Functional Assays for the Interpretation of Human Genetic Variation.	Annu Rev Genet	2022
36710959	Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein.	J Extracell Biol	2022
33300982	Prioritizing genes for systematic variant effect mapping.	Bioinformatics	2021
34861178	Improved pathogenicity prediction for rare human missense variants.	Am J Hum Genet	2021
34551312	Improved pathogenicity prediction for rare human missense variants.	Am J Hum Genet	2021
34214447	Shifting landscapes of human MTHFR missense-variant effects.	Am J Hum Genet	2021
34293323	Seeds of their own destruction: Dominant-negative peptide screening yields functional insight and therapeutic leads.	Cell Syst	2021
32251504	MaveQuest: a web resource for planning experimental tests of human variant effects.	Bioinformatics	2020
32000841	A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase.	Genome Med	2020
31668799	Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network.	Cell Syst	2020
33060198	Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.	J Biol Chem	2020
32939983	Systematic analysis of bypass suppression of essential genes.	Mol Syst Biol	2020
32763951	A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions.	G3 (Bethesda)	2020
32870157	Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.	Elife	2020
32392905	Yeast-Based Genetic Interaction Analysis of Human Kinome.	Cells	2020
32203420	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	Nat Cell Biol	2020
32296183	A reference map of the human binary protein interactome.	Nature	2020
30649215	A web application and service for imputing and visualizing missense variant effect maps.	Bioinformatics	2019
31679514	MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect.	Genome Biol	2019
31344031	Quantifying immune-based counterselection of somatic mutations.	PLoS Genet	2019
31283071	Assessing predictions on fitness effects of missense variants in calmodulin.	Hum Mutat	2019
31105571	Characterizing ABC-Transporter Substrate-Likeness Using a Clean-Slate Genetic Background.	Front Pharmacol	2019
30747104	<i>CNTN5</i><sup>-</sup><i><sup>/+</sup></i>or <i>EHMT2</i><sup>-</sup><i><sup>/+</sup></i>human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks.	Elife	2019
30006486	The Impact of Oncogenic EGFRvIII on the Proteome of Extracellular Vesicles Released from Glioblastoma Cells.	Mol Cell Proteomics	2018
29807908	Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.	Mol Syst Biol	2018
30073413	Multiplexed assays of variant effects contribute to a growing genotype-phenotype atlas.	Hum Genet	2018
30150706	Modeling the impact of drug interactions on therapeutic selectivity.	Nat Commun	2018
27994090	A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and <i>N</i><sup>1</sup>-methyladenosine modification.	RNA	2017
28346509	Systematic identification of phosphorylation-mediated protein interaction switches.	PLoS Comput Biol	2017
29269382	A framework for exhaustively mapping functional missense variants.	Mol Syst Biol	2017
29163459	CRISPR/Cas9 System as a Valuable Genome Editing Tool for Wine Yeasts with Application to Decrease Urea Production.	Front Microbiol	2017
28542158	Identifying pathogenicity of human variants via paralog-based yeast complementation.	PLoS Genet	2017
28886340	Variant Interpretation: Functional Assays to the Rescue.	Am J Hum Genet	2017
28705884	Quantitative analysis of protein interaction network dynamics in yeast.	Mol Syst Biol	2017
28596290	Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target.	Genome Res	2017
28817247	Assessing predictions of fitness effects of missense mutations in SUMO-conjugating enzyme UBE2I.	Hum Mutat	2017
26871637	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	Cell	2016

1 - 50 of 158

Arthur Wuster

Genentech Inc.

Career Start Year 2008

Number of shared co-authors 2

Yana Bromberg

Rutgers University

Career Start Year 2003

Number of shared co-authors 7

Patrick Kemmeren

Princess Maxima Center for Pediatric Oncology

Career Start Year 2002

Number of shared co-authors 3

Predrag Radivojac

Indiana University

Career Start Year 2002

Number of shared co-authors 15

Zhaolei Zhang

University of Toronto

Career Start Year 2002

Number of shared co-authors 26

Roland Krause

University of Luxembourg

Career Start Year 2002

Number of shared co-authors 6

Johan Rung

Uppsala University

Career Start Year 2001

Number of shared co-authors 1

Sean D Mooney

University of Washington

Career Start Year 2001

Number of shared co-authors 18

Maricel G Kann

University of Maryland

Career Start Year 2000

Number of shared co-authors 4

Roded Sharan

Tel Aviv University

Career Start Year 2000

Number of shared co-authors 5

Wei Wang

IBM Thomas J Watson Research Center, University of California Los Angeles, University of North Carolina at Chapel Hill

Career Start Year 1999

Number of shared co-authors 4

Lars Juhl Jensen

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen

Career Start Year 1998

Number of shared co-authors 8

Yan Cui

University of Tennessee Health Science Center

Career Start Year 1998

Number of shared co-authors 0

Rachel Karchin

Johns Hopkins University

Career Start Year 1998

Number of shared co-authors 16

Melissa S Cline

Genomics Institute, University of California Santa Cruz

Career Start Year 1997

Number of shared co-authors 15

Trey Ideker (CM4AI)

University of California San Diego

Career Start Year 1996

Number of shared co-authors 38

Ron Shamir

Tel Aviv University

Career Start Year 1995

Number of shared co-authors 5

Elizabeth A Worthey

Heersink School of Medicine, The University of Alabama at Birmingham

Career Start Year 1995

Number of shared co-authors 14

Christopher T Workman

Technical University of Denmark

Career Start Year 1995

Number of shared co-authors 4

Steven J M Jones

University of British Columbia

Career Start Year 1995

Number of shared co-authors 23

Ioannis Xenarios

University of Lausanne

Career Start Year 1994

Number of shared co-authors 18

Mark Yandell

University of Utah

Career Start Year 1994

Number of shared co-authors 7

Terry Gaasterland

Scripps Institution of Oceanography, University of California San Diego

Career Start Year 1994

Number of shared co-authors 9

Steven E Brenner

University of California berkeley

Career Start Year 1994

Number of shared co-authors 27

Simon Kasif

Boston University

Career Start Year 1993

Number of shared co-authors 5

Ewan Birney

European Bioinformatics Institute

Career Start Year 1992

Number of shared co-authors 28

Andreas Beyer

University of Cologne

Career Start Year 1991

Number of shared co-authors 4

Robert Gentleman

Center for Computational Biomedicine, Harvard Medical School

Career Start Year 1991

Number of shared co-authors 6

Eric S Lander

Vanderbilt-Ingram Cancer Center, Vanderbilt University

Career Start Year 1986

Number of shared co-authors 35

Stanley Fields

University of Washington

Career Start Year 1985

Number of shared co-authors 21

row(s) 1 - 30 of 30

Marc Vidal

Blavatnik Institute, Harvard Medical School

Co-authored papers 37

Gabriel F Berriz

Harvard Medical School

Co-authored papers 13

Charles Boone

University of Toronto

Co-authored papers 12

Brenda J Andrews

University of Toronto

Co-authored papers 11

Francis D Gibbons

Preclinical and Translational Sciences, Inc.

Co-authored papers 11

Haiyuan Yu

Weill Institute for Cell and Molecular Biology, Cornell University

Co-authored papers 10

Marinella Gebbia

University of Toronto

Co-authored papers 10

Lan V Zhang

Harvard Medical School

Co-authored papers 10

Can Cenik

Co-authored papers 9

Patrick Aloy

Institucio Catalana de Recerca i Estudis Avancats (ICREA)

Co-authored papers 9

Kavitha Venkatesan

Co-authored papers 8

Albert-L??szl?? Barab??si

Network Science Institute, Northeastern University

Co-authored papers 8

Debra S Goldberg

University of Colorado at Boulder

Co-authored papers 8

Sharyl L Wong

Harvard Medical School

Co-authored papers 8

Nozomu Yachie

The University of British Columbia

Co-authored papers 7

Nicolas Simonis

Co-authored papers 7

Yu Xia

College of Information Engineering, Zhejiang University of Technology

Co-authored papers 6

Anne-Ruxandra Carvunis

University of Pittsburgh School of Medicine.

Co-authored papers 6

Adnan Derti

Co-authored papers 6

Michael Costanzo

Co-authored papers 6

Nicolas Bertin

University Bordeaux, CNRS

Co-authored papers 6

Weidong Tian

Institute of Biostatistics, Fudan University

Co-authored papers 6

Anne-Claude Gingras

Lunenfeld-Tanenbaum Research Institute

Co-authored papers 6

Song Yi

Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin

Co-authored papers 6

Douglas M Fowler

University of Washington, USA Brotman Baty Institute for Precision Medicine

Co-authored papers 5

Robert E Gerszten

Co-authored papers 5

Chad L Myers

University of Minnesota - Twin Cities

Co-authored papers 5

Rahul C Deo

Co-authored papers 5

Carles Pons

Co-authored papers 5

Nidhi Sahni

The University of Texas MD Anderson Cancer Center

Co-authored papers 5

1 - 30

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