Author details

Full Name

Eric A Sobie

Affiliation

ORCID

Career Start Year

1995

Papers

120

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36914446	Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients.	Trends Pharmacol Sci	2023
37101545	Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors.	Front Pharmacol	2023
35325615	PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.	Cell Stem Cell	2022
36056380	Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation.	Stem Cell Research and Therapy	2022
36409762	Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models.	PLoS Computational Biology	2022
35598117	Quantitative approaches to drug safety: The 2022 PSP special issue.	CPT: Pharmacometrics and Systems Pharmacology	2022
35058449	Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity.	Sci Data	2022
34650052	Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.	Nature Communications	2021
34298582	CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision.	CPT: Pharmacometrics and Systems Pharmacology	2021
33953668	Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development.	Frontiers in Pharmacology	2021
33679437	and Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic "COVID-19 Cardiomyocyte".	Frontiers in Physiology	2021
33941686	Protein structure-based gene expression signatures.	Proc Natl Acad Sci U S A	2021
33205613	Investigational Treatments for COVID-19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions.	CPT: Pharmacometrics and Systems Pharmacology	2021
33326834	The role of Î²-adrenergic system remodeling in human heart failure: A mechanistic investigation.	Journal of Molecular and Cellular Cardiology	2021
34739849	A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals.	Stem Cell Reports	2021
34493665	Prediction of arrhythmia susceptibility through mathematical modeling and machine learning.	Proceedings of the National Academy of Sciences of the United States of America	2021
32511528	Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions.		2020
32339567	A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant.	Journal of Molecular and Cellular Cardiology	2020
31758700	Pharmacometrics and Systems Pharmacology 2030.	Clin Pharmacol Ther	2020
31709525	General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.	Clin Pharmacol Ther	2020
32330487	Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and Î²-adrenergic signaling.	Journal of Molecular and Cellular Cardiology	2020
32968055	Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity.	Nat Commun	2020
30859176	Holistic optimization of an RNA-seq workflow for multi-threaded environments.		2019
31521606	Building Containerized Workflows Using the BioDepot-Workflow-Builder.		2019
29199020	The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.	Cell Syst	2018
30354408	Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species: A Computational Study.	Circulation: Arrhythmia and Electrophysiology	2018
30190684	Ca Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations.	Frontiers in Physiology	2018
29987808	An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.	Methods in Molecular Biology	2018
29899058	A privileged role for neuronal Na channels in regulating ventricular [Ca] and arrhythmias.	Journal of General Physiology	2018
29507757	Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.	npj Systems Biology and Applications	2018
27618710	Response to "Complexity vs. Simplicity: The Winner Is?" Mechanism-Based Classifiers Provide More Than Just Classification.	Clinical Pharmacology and Therapeutics	2017
28951721	Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.	Front Physiol	2017
28642329	Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.	Circ Res	2017
28798276	Ambiguous interactions between diastolic and SR Ca in the regulation of cardiac Ca release.	Journal of General Physiology	2017
29116112	A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.	Sci Rep	2017
27913283	I love it when a plan comes together: Insight gained through convergence of competing mathematical models.	Journal of Molecular and Cellular Cardiology	2017
27779762	Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.	Journal of Physiology	2017
27559151	A network medicine approach to build a comprehensive atlas for the prognosis of human cancer.	Brief Bioinform	2016
27296897	Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea-pigs.	Journal of Physiology	2016
26964092	The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation.	PLoS ONE	2016
26950176	Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms.	Clinical Pharmacology and Therapeutics	2016
27454812	Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.	PLoS Computational Biology	2016
26661516	Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms.	Journal of Physiology	2016
26235057	There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes.	Journal of Molecular and Cellular Cardiology	2016
27569062	Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.	Stem Cell Reports	2016
27605670	Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal Î±-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking.	Journal of Biological Chemistry	2016
27690302	Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data.	Oncotarget	2016
25995318	Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome.	Circulation	2015
25485896	Calcium homeostasis in a local/global whole cell model of permeabilized ventricular myocytes with a Langevin description of stochastic calcium release.	American Journal of Physiology - Heart and Circulatory Physiology	2015
25772298	Maximal acceleration of Ca2+ release refractoriness by Î²-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes.	Journal of Physiology	2015