Author details

Full Name

Joshua M Francis

Affiliation

ORCID

Career Start Year

2003

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34246985	Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy.	Neoplasia	2021
33115806	Chromatin Looping Shapes KLF5-Dependent Transcriptional Programs in Human Epithelial Cancers.	Cancer Res	2020
31862696	Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma.	Mol Cancer Res	2020
30664779	Small-molecule targeting of brachyury transcription factor addiction in chordoma.	Nat Med	2019
30082399	Genotype-targeted local therapy of glioma.	Proc Natl Acad Sci U S A	2018
28963353	Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.	Cancer Discov	2018
27975234	Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.	Invest New Drugs	2017
28679620	Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.	Genome Res	2017
29109393	Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors.	Nat Commun	2017
28049633	Progressive epigenetic dysregulation in neuroendocrine tumour liver metastases.	Endocr Relat Cancer	2017
27801610	Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.	Cancer Biol Ther	2016
26883194	Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.	Oncotarget	2016
26656844	Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.	Nat Genet	2016
26169971	Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.	Clin Cancer Res	2016
27806376	Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.	Nature	2016
26181761	Rapid Intraoperative Molecular Characterization of Glioma.	JAMA Oncol	2015
25879913	Calibrating genomic and allelic coverage bias in single-cell sequencing.	Nat Commun	2015
25537453	Dynamic epigenetic regulation by menin during pancreatic islet tumor formation.	Mol Cancer Res	2015
25826094	Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants.	Oncotarget	2015
25963524	ARID1A and TERT promoter mutations in dedifferentiated meningioma.	Cancer Genet	2015
25957691	Prospective derivation of a living organoid biobank of colorectal cancer patients.	Cell	2015
26017310	Chromothripsis from DNA damage in micronuclei.	Nature	2015
24752078	Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer.	Nat Biotechnol	2014
25589003	Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.	Acta Neuropathol Commun	2014
25347344	Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.	Oncotarget	2014
24590290	SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas.	J Clin Invest	2014
24893890	EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing.	Cancer Discov	2014
23322301	Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.	Genes Dev	2013
24063894	Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.	Cancer Res	2013
24185511	Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.	Nat Genet	2013
22722202	Sequence analysis of mutations and translocations across breast cancer subtypes.	Nature	2012
21788502	Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.	Proc Natl Acad Sci U S A	2011
21264250	The menin tumor suppressor protein is phosphorylated in response to DNA damage.	PLoS One	2011
19136632	The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.	Proc Natl Acad Sci U S A	2009
16901969	Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.	Molecular Endocrinology	2006
15743769	Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.	J Biol Chem	2005
16141209	Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.	Journal of Biological Chemistry	2005
12711597	Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.	Journal of Biological Chemistry	2003