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| 37421950 | Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies. | | 2023 |
| 37608574 | Treatments with the specific δ-secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury. | | 2023 |
| 37673907 | Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice. | Nat Commun | 2023 |
| 37583253 | Zein-Based Nanoparticles Improve the Therapeutic Efficacy of a TrkB Agonist toward Alzheimer's Disease. | | 2023 |
| 37257680 | Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. | | 2023 |
| 36543925 | Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease. | | 2023 |
| 36735152 | C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis. | | 2023 |
| 36609384 | C/EBPβ/AEP is age-dependently activated in Parkinson's disease and mediates α-synuclein in the gut and brain. | | 2023 |
| 36604761 | Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice. | | 2023 |
| 34689722 | Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice. | | 2022 |
| 35973996 | A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin. | Nature Communications | 2022 |
| 35443102 | A synapsin â¿ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. | Aging Cell | 2022 |
| 35496909 | Oral Treatments With the TrkB Ligand Prodrug, R13, Promote Enhanced Axon Regeneration Following Peripheral Nerve Injury. | Frontiers in Cellular Neuroscience | 2022 |
| 35422468 | C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease. | Molecular Psychiatry | 2022 |
| 35546632 | High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPβ/AEP pathway. | Molecular Psychiatry | 2022 |
| 35353567 | Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. | Sci Adv | 2022 |
| 36054165 | Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration. | Movement Disorders | 2022 |
| 35595958 | Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase. | | 2022 |
| 36544221 | CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals. | | 2022 |
| 35332321 | Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. | Nature Structural and Molecular Biology | 2022 |
| 35236988 | FSH blockade improves cognition in mice with Alzheimer's disease. | Nature | 2022 |
| 35023303 | UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. | Advanced Science | 2022 |
| 34958873 | Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model. | Progress in Neurobiology | 2022 |
| 35017199 | Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. | Gut | 2022 |
| 34480114 | Author Correction: Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth. | Acta Pharmacologica Sinica | 2022 |
| 30382187 | δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. | Molecular Psychiatry | 2021 |
| 32086435 | C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB. | Molecular Psychiatry | 2021 |
| 34018922 | Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. | eLife | 2021 |
| 34227467 | 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis. | eLife | 2021 |
| 34166772 | Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease. | Progress in Neurobiology | 2021 |
| 33895869 | ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. | Acta Neuropathologica | 2021 |
| 33677035 | Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease. | Neurobiology of Disease | 2021 |
| 34158346 | C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis. | Molecular Cancer Therapeutics | 2021 |
| 34106682 | Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase. | ACS Chemical Neuroscience | 2021 |
| 33992672 | A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. | Progress in Neurobiology | 2021 |
| 33880508 | A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies. | Brain | 2021 |
| 34260075 | Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease. | EMBO Journal | 2021 |
| 33716161 | ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. | Progress in Neurobiology | 2021 |
| 34348155 | Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. | Cell Rep | 2021 |
| 34343610 | Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease. | Neuropharmacology | 2021 |
| 33863723 | Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. | Science advances | 2021 |
| 33352311 | Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice. | Molecular Metabolism | 2021 |
| 33351190 | Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. | EMBO Journal | 2021 |
| 32911010 | BDNF and Netrin-1 repression by C/EBPβ in the gut triggers Parkinson's disease pathologies, associated with constipation and motor dysfunctions. | Progress in Neurobiology | 2021 |
| 33339957 | C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. | Molecular Psychiatry | 2021 |
| 32782380 | TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies. | Molecular Psychiatry | 2021 |
| 33323399 | Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer's Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves. | eNeuro | 2021 |
| 34744697 | Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease. | Frontiers in Aging Neuroscience | 2021 |
| 34489530 | Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice. | Molecular Psychiatry | 2021 |
| 32832679 | Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model. | Science advances | 2020 |