Author details

Full Name

Nunzio Bottini

Affiliation

ORCID

Career Start Year

1997

Papers

176

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36693907	Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders.		2023
38016062	Immunomodulatory Nanoparticles for Modulating Arthritis Flares.		2023
37909274	Inhibiting the inhibitor in synovial macrophages and cancer immunotherapy-associated inflammatory arthritis.		2023
37409507	Revisiting VH1 phosphatase at the time of monkeypox: back to the spotlight.		2023
37402225	Clustering of phosphatase RPTPÎ± promotes Src signaling and the arthritogenic action of synovial fibroblasts.		2023
36890657	Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.	Adv Sci (Weinh)	2023
36566262	Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro.	Drug Deliv Transl Res	2023
35600637	Lipid-based regulators of immunity.	Bioengineering and Translational Medicine	2022
35655388	T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation.	British Journal of Haematology	2022
35451370	Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex.	JCI insight	2022
36328244	Macromolecular crowding amplifies allosteric regulation of T-cell protein tyrosine phosphatase.	Journal of Biological Chemistry	2022
35476502	Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis.	American Journal of Physiology - Cell Physiology	2022
34380042	Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.	Cell Reports	2021
33914534	Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.	J Med Chem	2021
33615467	The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.	Journal of Cellular Physiology	2021
33055428	PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.	JCI Insight	2020
32139509	RPTPÎ± phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.	Journal of Biological Chemistry	2020
32184287	PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling.	Sci Signal	2020
32637608	Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.	Sci Adv	2020
30808624	PTPN14 phosphatase and YAP promote TGFÎ² signalling in rheumatoid synoviocytes.	Ann Rheum Dis	2019
30507064	The Contribution of PTPN22 to Rheumatic Disease.	Arthritis and Rheumatology	2019
30620725	Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.	J Clin Invest	2019
30978282	Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy.	ACS Nano	2019
29334180	Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery.	Advanced healthcare materials	2018
29980684	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.	Nature Communications	2018
29057934	PTP4A1 promotes TGFÎ² signaling and fibrosis in systemic sclerosis.	Nat Commun	2017
28346406	Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.	Nat Chem Biol	2017
28412041	Targeting Tyrosine Phosphatases: Time to End the Stigma.	Trends in Pharmacological Sciences	2017
28322585	Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.	Epigenomics	2017
28397126	Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.	Current Rheumatology Reports	2017
27841348	CD45-mediated control of TCR tuning in naÃ¯ve and memory CD8 T cells.	Nature Communications	2016
25378349	TGFÎ² responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.	Ann Rheum Dis	2016
27056269	T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.	Journal of Allergy and Clinical Immunology	2016
27275015	Abnormal <i>PTPN11</i> enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.	JCI Insight	2016
26657854	Chondrocyte clocks make cartilage time-sensitive material.	Journal of Clinical Investigation	2016
26414708	Receptor Protein Tyrosine Phosphatase Î±-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.	Arthritis Rheumatol	2016
26707894	Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy.	Nanomedicine: Nanotechnology, Biology, and Medicine	2016
25995222	Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.	Sci Transl Med	2015
26061731	Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.	PLoS ONE	2015
26438525	Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.	Journal of Immunology	2015
26390844	Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside.	Nature reviews. Rheumatology	2015
26213100	Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.	Journal of Pathology	2015
24730253	Targeted nanodrugs for cancer therapy: prospects and challenges.	Journal of Nanoscience and Nanotechnology (discontinued)	2014
25415768	Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.	ACS Nano	2014
24403103	Covalent inhibition of the lymphoid tyrosine phosphatase.	ChemMedChem	2014
24294920	Cellular biochemistry methods for investigating protein tyrosine phosphatases.	Antioxidants and Redox Signaling	2014
23886911	pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays.	Methods	2014
24498279	Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.	PLoS One	2014
24364806	Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.	Annu Rev Immunol	2014
24905474	The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization.	Clinical and Experimental Immunology	2014