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Author Details

Christopher D Fjell
St. Paul's Hospital, University of British Columbia
1994
53
31
PMIDPaper TitleJournal TitlePublished Year
35084500Comparative Single-Dose mRNA and ChAdOx1 Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2, Including Variants of Concern: Test-Negative Design, British Columbia, Canada.J Infect Dis2022
35438175Two-Dose Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Effectiveness With Mixed Schedules and Extended Dosing Intervals: Test-Negative Design Studies From British Columbia and Quebec, Canada.Clin Infect Dis2022
35641782DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis.Cell Death Differ2022
35859775Spike Mutation Profiles Associated With SARS-CoV-2 Breakthrough Infections in Delta Emerging and Predominant Time Periods in British Columbia, Canada.Front Public Health2022
34388358Rapid Increase in SARS-CoV-2 P.1 Lineage Leading to Codominance with B.1.1.7 Lineage, British Columbia, Canada, January-April 2021.Emerg Infect Dis2021
31242491The Specific Organism: Not Bacterial Gram Type: Drives the Inflammatory Response in Septic Shock.J Innate Immun2020
32207249Urine biomarkers of renal renin-angiotensin system activity: Exploratory analysis in humans with and without obstructive sleep apnea.Physiol Rep2020
31332258Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients.Sci Rep2019
27618276Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients.Crit Care Med2017
26756586Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis.J Innate Immun2016
26347487TNFAIP2 Inhibits Early TNFα-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients.J Innate Immun2016
27071387Plasma cytokine levels predict response to corticosteroids in septic shock.Intensive Care Med2016
26849681In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents.PLoS One2016
25896417VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock.J Innate Immun2015
24485960Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery.J Thorac Cardiovasc Surg2014
25685830An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.EBioMedicine2014
25320235PCSK9 is a critical regulator of the innate immune response and septic shock outcome.Sci Transl Med2014
24836792Could altered leukocyte gene expression profile in trauma patients guide immune interventions to prevent gram-negative bacteremia?Crit Care Med2014
24949855A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.PLoS One2014
24907323Knockout of extracytoplasmic function sigma factor ECF-10 affects stress resistance and biofilm formation in Pseudomonas putida KT2440.Appl Environ Microbiol2014
24601781Small acute increases in serum creatinine are associated with decreased long-term survival in the critically ill.Am J Respir Crit Care Med2014
24525633The meta-genome of sepsis: host genetics, pathogens and the acute immune response.J Innate Immun2014
24339166Innate defense regulator peptide 1018 protects against perinatal brain injury.Ann Neurol2014
24335447A multibiomarker-based outcome risk stratification model for adult septic shock*.Crit Care Med2014
23308112Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation.PLoS One2013
24244449Cytokines and signaling molecules predict clinical outcomes in sepsis.PLoS One2013
23796235Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock.Am J Respir Crit Care Med2013
23766290INMEX--a web-based tool for integrative meta-analysis of expression data.Nucleic Acids Res2013
23487427Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.J Immunol2013
23264659Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.J Immunol2013
22061966A systems biology approach to nutritional immunology - focus on innate immunity.Mol Aspects Med2012
23105139Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.J Immunol2012
20942839Optimization of antibacterial peptides by genetic algorithms and cheminformatics.Chem Biol Drug Des2011
22173434Designing antimicrobial peptides: form follows function.Nat Rev Drug Discov2011
21576504Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells.J Immunol2011
19055425Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs.ACS Chem Biol2009
19171306Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.Chem Biol2009
19296598Identification of novel antibacterial peptides by chemoinformatics and machine learning.J Med Chem2009
17847019QSAR modeling and computer-aided design of antimicrobial peptides.J Pept Sci2008
18726572Short linear cationic antimicrobial peptides: screening, optimizing, and prediction.Methods Mol Biol2008
18442133Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome.Proteins2008
17210078DiscoverySpace: an interactive data analysis application.Genome Biol2007
17683374Evaluating different descriptors for model design of antimicrobial peptides with enhanced activity toward P. aeruginosa.Chem Biol Drug Des2007
17341497AMPer: a database and an automated discovery tool for antimicrobial peptides.Bioinformatics2007
17488239A physical map of the highly heterozygous Populus genome: integration with the genome sequence and genetic map and analysis of haplotype variation.Plant J2007
16381958cisRED: a database system for genome-scale computational discovery of regulatory elements.Nucleic Acids Res2006
16026963A physical map of the genome of Atlantic salmon, Salmo salar.Genomics2005
15057822Genome sequence of the Brown Norway rat yields insights into mammalian evolution.Nature2004
14871860Automated ordering of fingerprinted clones.Bioinformatics2004
15060021Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome.Genome Res2004
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Collaborators

University of British Columbia
Co-authored papers 20
St. Paul's Hospital, University of British Columbia
Co-authored papers 16
University of British Columbia
Co-authored papers 14
University of British Columbia
Co-authored papers 14
University of British Columbia
Co-authored papers 8
University of British Columbia
Co-authored papers 8
Canada British Columbia Cancer Research Centre, University of British Columbia
Co-authored papers 7
Boston Children's Hospital
Co-authored papers 6
BC Cancer Research Center
Co-authored papers 6
University of British Columbia
Co-authored papers 6
Department of Research and Development, Inc.
Co-authored papers 4
Co-authored papers 4
Center for Genetics, Children's Hospital Oakland Research Institute
Co-authored papers 4
Co-authored papers 3
Ontario Institute for Cancer Research
Co-authored papers 3
University of Pennsylvania Philadelphia
Co-authored papers 2
Co-authored papers 2
University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
University of Washington
Co-authored papers 2
Co-authored papers 2
European Bioinformatics Institute
Co-authored papers 2
BC Cancer Research Institute
Co-authored papers 2
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 2
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Baylor College of Medicine
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
National Human Genome Research Institute
Co-authored papers 1