Author details

Full Name

Donna Reichart

Affiliation

ORCID

Career Start Year

1987

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36797483	Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice.	Nat Med	2023
37767697	Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation.	Circ Genom Precis Med	2023
35787042	Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.	Proc Natl Acad Sci U S A	2022
35926050	Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.	Science	2022
36321451	Pathogenesis of Cardiomyopathy Caused by Variants in <i>ALPK3</i>, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere.	Circulation	2022
25139986	Phospholipase A2 regulates eicosanoid class switching during inflammasome activation.	Proc Natl Acad Sci U S A	2014
24189069	25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.	J Biol Chem	2013
23021221	Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.	Cell	2012
21653236	Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype.	J Leukoc Biol	2011
21499735	Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.	J Mol Med (Berl)	2011
22174696	Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.	PLoS Genet	2011
21703401	Migration of fibrocytes in fibrogenic liver injury.	Am J Pathol	2011
20923771	A mouse macrophage lipidome.	J Biol Chem	2010
20876532	Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy.	J Biol Chem	2010
18509338	Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.	Nature	2008
17525798	Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.	J Clin Invest	2007
17916553	A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.	J Biol Chem	2007
16479018	Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.	J Lipid Res	2006
12031980	Female rats do not exhibit free fatty acid-induced insulin resistance.	Diabetes	2002
11574414	Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.	Diabetes	2001
11707596	Synthesis of an organoinsulin molecule that can be activated by antibody catalysis.	Proc Natl Acad Sci U S A	2001
11118020	Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.	Diabetes	2000
9515800	Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.	Cancer Research	1998
9737973	Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport.	J Biol Chem	1998
9166671	Mechanisms of the kinetic defect in insulin action in obesity and NIDDM.	Diabetes	1997
8665514	Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.	Cancer Research	1996
8826975	Protein tyrosine phosphatase 1B interacts with the activated insulin receptor.	Diabetes	1996
7622001	Kinetics of insulin action in vivo. Identification of rate-limiting steps.	Diabetes	1995
7895674	A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.	Endocrinology	1995
7642582	Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein.	J Biol Chem	1995
8262308	Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle.	Diabetes	1994
7525547	Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.	J Biol Chem	1994
8106637	Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.	J Clin Endocrinol Metab	1994
8116725	Mechanisms of cellular insulin resistance in human pregnancy.	Am J Obstet Gynecol	1994
1322430	Cellular mechanisms of insulin resistance in polycystic ovarian syndrome.	J Clin Endocrinol Metab	1992
1645756	In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.	J Clin Invest	1991
3170749	Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.	J Clin Invest	1988
3540010	Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.	J Clin Invest	1987