| 37308266 | Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis. | J Pharmacol Exp Ther | 2023 |
| 37598239 | JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. | Sci Rep | 2023 |
| 37973811 | Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. | Sci Rep | 2023 |
| 36279149 | Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor. | J Med Chem | 2022 |
| 35428514 | Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies. | Placenta | 2022 |
| 32142284 | Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase. | J Med Chem | 2020 |
| 34345355 | New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. | ACS Med Chem Lett | 2020 |
| 29874096 | Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening. | Assay Drug Dev Technol | 2018 |
| 30134246 | Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist. | Pharmacology | 2018 |
| 24847974 | A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). | J Med Chem | 2014 |
| 22174317 | Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. | Mol Cell Proteomics | 2012 |
| 22051512 | DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. | J Mol Biol | 2012 |
| 22123199 | The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold. | J Mol Biol | 2012 |
| 20677820 | Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries. | ACS Chem Biol | 2010 |
| 20869252 | Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport. | Bioorg Med Chem | 2010 |
| 16288868 | A neural network based classification scheme for cytotoxicity predictions:Validation on 30,000 compounds. | Bioorg Med Chem Lett | 2006 |
| 16040602 | A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations. | J Biol Chem | 2005 |
| 14725788 | Differential substrate and inhibitor profiles for human MASP-1 and MASP-2. | Mol Immunol | 2004 |
| 15364579 | The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions. | J Mol Biol | 2004 |
| 12538697 | Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments. | J Immunol | 2003 |
| 12396001 | C1s, the protease messenger of C1. Structure, function and physiological significance. | Immunobiology | 2002 |
| 12396008 | The biological functions of MBL-associated serine proteases (MASPs). | Immunobiology | 2002 |
| 12369900 | Structure and function of complement activating enzyme complexes: C1 and MBL-MASPs. | Curr Protein Pept Sci | 2001 |
| 10925288 | The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex. | J Immunol | 2000 |
| 10698339 | Activities of the MBL-associated serine proteases (MASPs) and their regulation by natural inhibitors. | Mol Immunol | 1999 |