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Author Details

G??za Ambrus
University of California San Diego (university of california san diego)
1999
25
15
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37308266Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.J Pharmacol Exp Ther2023
37598239JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.Sci Rep2023
37973811Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.Sci Rep2023
36279149Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.J Med Chem2022
35428514Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies.Placenta2022
32142284Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.J Med Chem2020
34345355New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.ACS Med Chem Lett2020
29874096Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening.Assay Drug Dev Technol2018
30134246Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist.Pharmacology2018
24847974A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).J Med Chem2014
22174317Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.Mol Cell Proteomics2012
22051512DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.J Mol Biol2012
22123199The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.J Mol Biol2012
20677820Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.ACS Chem Biol2010
20869252Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport.Bioorg Med Chem2010
16288868A neural network based classification scheme for cytotoxicity predictions:Validation on 30,000 compounds.Bioorg Med Chem Lett2006
16040602A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations.J Biol Chem2005
14725788Differential substrate and inhibitor profiles for human MASP-1 and MASP-2.Mol Immunol2004
15364579The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.J Mol Biol2004
12538697Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.J Immunol2003
12396001C1s, the protease messenger of C1. Structure, function and physiological significance.Immunobiology2002
12396008The biological functions of MBL-associated serine proteases (MASPs).Immunobiology2002
12369900Structure and function of complement activating enzyme complexes: C1 and MBL-MASPs.Curr Protein Pept Sci2001
10925288The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex.J Immunol2000
10698339Activities of the MBL-associated serine proteases (MASPs) and their regulation by natural inhibitors.Mol Immunol1999
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