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Author Details

Leonard D Shultz
The Jackson Laboratory Cancer Center
1971
484
94
PMIDPaper TitleJournal TitlePublished Year
37816504Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.Mol Cancer Ther2024
37816504Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.Mol Cancer Ther2024
36635480Humanized mouse models for immuno-oncology research.Nat Rev Clin Oncol2023
38014123A human immune/muscle xenograft model of FSHD muscle pathology.bioRxiv2023
38049589Genetic risk converges on regulatory networks mediating early type 2 diabetes.Nature2023
37219526Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.FASEB J2023
36635480Humanized mouse models for immuno-oncology research.Nat Rev Clin Oncol2023
37327334Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.Sci Adv2023
37386161Generation of the NeoThy mouse model for human immune system studies.Lab Anim (NY)2023
36801998NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.J Leukoc Biol2023
36800412Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis.Sci Immunol2023
36851579Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection.Viruses2023
38014123A human immune/muscle xenograft model of FSHD muscle pathology.bioRxiv2023
38049589Genetic risk converges on regulatory networks mediating early type 2 diabetes.Nature2023
37219526Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.FASEB J2023
37386161Generation of the NeoThy mouse model for human immune system studies.Lab Anim (NY)2023
37327334Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.Sci Adv2023
36851579Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection.Viruses2023
36801998NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.J Leukoc Biol2023
36800412Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis.Sci Immunol2023
34057741A novel clinically relevant graft-versus-leukemia model in humanized mice.J Leukoc Biol2022
35908547Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.Immunity2022
35619037Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.Methods Mol Biol2022
36476935Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.Cell Metab2022
36684105Clathrin light chain-conjugated drug delivery for cancer.Bioeng Transl Med2022
34057741A novel clinically relevant graft-versus-leukemia model in humanized mice.J Leukoc Biol2022
34773575Circulating CD34+â¿¿cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.Int J Hematol2022
35619037Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.Methods Mol Biol2022
36476935Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.Cell Metab2022
36684105Clathrin light chain-conjugated drug delivery for cancer.Bioeng Transl Med2022
35908547Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.Immunity2022
34773575Circulating CD34+â¿¿cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.Int J Hematol2022
34477920Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models.Mamm Genome2021
33581643Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.EBioMedicine2021
33552509Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.Clin Transl Immunology2021
34571853Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models.Cells2021
34599030Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.J Immunother Cancer2021
34477920Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models.Mamm Genome2021
35121960Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia.Nat Cancer2021
33581643Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.EBioMedicine2021
33552509Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.Clin Transl Immunology2021
35121960Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia.Nat Cancer2021
34571853Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models.Cells2021
34599030Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.J Immunother Cancer2021
32428240Dapagliflozin Does Not Directly Affect Human α or β Cells.Endocrinology2020
31914605Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.FASEB J2020
32428240Dapagliflozin Does Not Directly Affect Human α or β Cells.Endocrinology2020
32022317TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.J Leukoc Biol2020
31941840Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.JCI Insight2020
32387410Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.Drug Discov Today2020
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Collaborators

John P Mordes
Co-authored papers 22
Merrill Eric Gershwin
Allergy and Clinical Immunology, University of California at Davis
Co-authored papers 12
Osamu Ohara
Co-authored papers 11
Terry F Davies
Thyroid Research Unit, Icahn School of Medicine at Mount Sinai
Co-authored papers 8
John E Dick
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Nripesh Prasad
HudsonAlpha Institute for Biotechnology, Heersink School of Medicine
Co-authored papers 4
Shawn Levy
HudsonAlpha Institute for Biotechnology
Co-authored papers 4
Christian Mueller
Co-authored papers 4
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Co-authored papers 3
Diane C Saunders
Vanderbilt University Medical Center
Co-authored papers 3
Shristi Shrestha
Center for Stem Cell Biology, Vanderbilt University
Co-authored papers 3
James E Bradner
Co-authored papers 3
Edison T Liu
USA The Jackson Laboratory Cancer Center
Co-authored papers 3
Curt I Civin
Center for Stem Cell Biology & Regenerative Medicine and.
Co-authored papers 2
Clive Wasserfall
Co-authored papers 2
Teresa P DiLorenzo
Universidad Cardenal Herrera-CEU, CEU Universities
Co-authored papers 2
Neal C Goodwin
Co-authored papers 2
Francesco Abate
Columbia University
Co-authored papers 2
Hiroshi Kitamura
Co-authored papers 2
Kevan C Herold
Yale University
Co-authored papers 2
Giorgio Inghirami
Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital
Co-authored papers 2
Terence R Flotte
Co-authored papers 2
Ravi Bhatia
University of Alabama at Birmingham
Co-authored papers 2
Carol J Bult
The Jackson Laboratory Cancer Center
Co-authored papers 2
Craig W Vander Kooi
Co-authored papers 2
Fran??oise R??dini
Nantes Universite, Inserm UMR 7, CNRS UMR 6075, Universite d'Angers
Co-authored papers 2
Jeremy Luban
Co-authored papers 2
Leslie M Shaw
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Qiushi Tang
Co-authored papers 2
Pradeep D Uchil
Co-authored papers 2
Release 1.2