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Author Details

Livio Trusolino
Candiolo Cancer Institute - FPO IRCCS
1993
132
58
PMIDPaper TitleJournal TitlePublished Year
36862005MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis.Mol Oncol2023
37585503Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer.Sci Transl Med2023
37189167Multi-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity.Genome Med2023
37079732CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.Bioinformatics2023
37063647EGAsubmitter: A software to automate submission of nucleic acid sequencing data to the European Genome-phenome Archive.Front Bioinform2023
36697438An mTOR feedback loop mediates the 'flare' ('rebound') response to MET tyrosine kinase inhibition.Sci Rep2023
36622698Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.Clin Cancer Res2023
36759506Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT).Cell Death Dis2023
34635836Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin.Nat Biotechnol2022
36332574Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.Cell Stem Cell2022
35931031Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.Cell Stem Cell2022
36151307Towards precision oncology with patient-derived xenografts.Nat Rev Clin Oncol2022
35240232TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer.Cancer Lett2022
35197630Effective drug combinations in breast, colon and pancreatic cancer cells.Nature2022
34359705Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.Cancers (Basel)2021
33795873Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.Nat Cell Biol2021
33820776Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes.Cancer Discov2021
33864051Precision oncology in metastatic colorectal cancer - from biology to medicine.Nat Rev Clin Oncol2021
34426441Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.Clin Cancer Res2021
34133926The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation.Cell Rep2021
34344756The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRAS<sup>G12C</sup> Inhibitors.Cancer Discov2021
32430388EGFR Blockade Reverts Resistance to KRAS<sup>G12C</sup> Inhibition in Colorectal Cancer.Cancer Discov2020
33066609Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models.Cancers (Basel)2020
32919890Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer.Clin Colorectal Cancer2020
32578942Innovations, challenges, and minimal information for standardization of humanized mice.EMBO Mol Med2020
33015526Intratumoral Transcriptome Heterogeneity Is Associated With Patient Prognosis and Sidedness in Patients With Colorectal Cancer Treated With Anti-EGFR Therapy From the CO.20 Trial.JCO Precis Oncol2020
32759276Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.Sci Transl Med2020
32988996Pertuzumab and trastuzumab emtansine in patients with HER2-amplified metastatic colorectal cancer: the phase II HERACLES-B trial.ESMO Open2020
32700762Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.Int J Cancer2020
32183295Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer.Cancers (Basel)2020
31164152Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models.J Exp Clin Cancer Res2019
31813455Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga.Trends Cancer2019
31699882Adaptive mutability of colorectal cancers in response to targeted therapies.Science2019
31375513Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.Clin Cancer Res2019
31287988The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy.Cancer Cell2019
31253177Evolving neoantigen profiles in colorectal cancers with DNA repair defects.Genome Med2019
31126969INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.Mol Syst Biol2019
30952821HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.Oncologist2019
30808777Plasma HER2 (<i>ERBB2</i>) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.Clin Cancer Res2019
30979792INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.Mol Syst Biol2019
30971826Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.Nature2019
28974546A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.Clin Cancer Res2018
29990497Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.Cancer Cell2018
29674709Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy.Nat Rev Cancer2018
29659677Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.Ann Oncol2018
29538669RET fusions in a small subset of advanced colorectal cancers at risk of being neglected.Ann Oncol2018
28561063Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.Nat Commun2017
28104906Interrogating open issues in cancer precision medicine with patient-derived xenografts.Nat Rev Cancer2017
29092942PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.Cancer Res2017
28912576Interrogating open issues in cancer medicine with patient-derived xenografts.Nat Rev Cancer2017
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Collaborators

Candiolo Cancer Institute - FPO IRCCS
Co-authored papers 72
Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO) - IRCCS
Co-authored papers 24
Co-authored papers 14
Royal College of Surgeons in Ireland (RCSI)
Co-authored papers 6
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 4
Netherlands Cancer Institute
Co-authored papers 4
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 4
Wellcome Sanger Institute
Co-authored papers 3
Netherlands Cancer Institute
Co-authored papers 3
Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital
Co-authored papers 3
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus
Co-authored papers 3
CNRS URA 5
Co-authored papers 3
CRUK Cambridge Institute, University of Cambridge
Co-authored papers 3
Oncode Institute, The Netherlands Cancer Institute
Co-authored papers 3
University of Cambridge
Co-authored papers 3
Co-authored papers 3
Netherlands Cancer Institute
Co-authored papers 3
Co-authored papers 2
Queen's University Belfast
Co-authored papers 2
University of Turin, Candiolo Cancer Institute, FPO-IRCCS
Co-authored papers 2
University Medical Centre Mannheim, University of Heidelberg
Co-authored papers 2
European Institute of Oncology IRCCS
Co-authored papers 2
Co-authored papers 2
The Jackson Laboratory Cancer Center
Co-authored papers 2
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Guardant Health Inc.
Co-authored papers 2
Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 1
Imperial College London
Co-authored papers 1
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1