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Author Details

Scott A Oakes
Pritzker School of Medicine, University of Chicago
1995
45
29
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37097227Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration.Invest Ophthalmol Vis Sci2023
35266954The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.J Cell Biol2022
35405004Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms.Blood Cancer Discov2022
35821981SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells.bioRxiv2022
33758843Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response.bioRxiv2021
32112719Endoplasmic Reticulum Stress Signaling in Cancer Cells.Am J Pathol2020
30431452A Medical Student Inquiry Behavior Assessment Tool: Development and Validity Evidence.Acad Med2019
31369399Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.J Clin Invest2019
27856431Endoplasmic reticulum proteostasis: a key checkpoint in cancer.Am J Physiol Cell Physiol2017
28139654CPEB4 links the clock and the UPR to protect the liver.Nat Cell Biol2017
29157429Bilateral Choroidal Metastases from Pancreatic Adenocarcinoma.Ophthalmology2017
25387057The role of endoplasmic reticulum stress in human pathology.Annu Rev Pathol2015
26585277Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.Curr Biol2015
26123108Proteostasis control by the unfolded protein response.Nat Cell Biol2015
26239530Erratum: Proteostasis control by the unfolded protein response.Nat Cell Biol2015
25733019CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.Stem Cell Reports2015
25501598Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.Cell Death Differ2015
24708899Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.Acta Neuropathol Commun2014
25018104Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Cell2014
25136121Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.Proc Natl Acad Sci U S A2014
22130538Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.J Virol2012
23086298Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.Nat Chem Biol2012
23042294IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Science2012
22802621Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.Proc Natl Acad Sci U S A2012
22883233IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Cell Metab2012
21146390Signaling cell death from the endoplasmic reticulum stress response.Curr Opin Cell Biol2011
22179045The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.Nat Cell Biol2011
20890041Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.J Clin Invest2010
21062993Akt and autophagy cooperate to promote survival of drug-resistant glioma.Sci Signal2010
19665977IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Cell2009
18035051A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.Biochem Biophys Res Commun2008
18426910Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.Mol Cell Biol2008
17881558Mitochondria control calcium entry at the immunological synapse.Proc Natl Acad Sci U S A2007
16472117The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.Curr Mol Med2006
15613488Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.Proc Natl Acad Sci U S A2005
15010700Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.EMBO J2004
15469833Untangling the web: mitochondrial fission and apoptosis.Dev Cell2004
12624178BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.Science2003
14555206Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.Biochem Pharmacol2003
11782314A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.Dev Cell2002
9054429Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency.J Biol Chem1997
9354668Structural and functional basis for JAK3-deficient severe combined immunodeficiency.Blood1997
8676091In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.J Exp Med1996
8986719Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.Immunity1996
7499365Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.J Biol Chem1995
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Collaborators

Feroz R Papa
University of California san francisco
Co-authored papers 10
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National Institute of Arthritis, National Institutes of Health
Co-authored papers 5
Andrei Goga
University of California San Francisco
Co-authored papers 4
Michael C Bassik
Stanford University Medical Center
Co-authored papers 3
Noelle E Huskey
Co-authored papers 3
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Stanford University School of Medicine
Co-authored papers 2
Charles D James
Co-authored papers 2
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University of California, San Diego and VA San Diego Healthcare System (D.G.
Co-authored papers 2
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Inserm U2, University of Rennes
Co-authored papers 2
Stephan C Sch??rer
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Co-authored papers 2
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Co-authored papers 2
Kevan M Shokat
University of California San Francisco
Co-authored papers 2
Archana Shenoy
Co-authored papers 1
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University of California san francisco
Co-authored papers 1
Theodore Nicolaides
Co-authored papers 1
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Co-authored papers 1
Davide Ruggero
University of California San Francisco
Co-authored papers 1
Timothy C Cox
University of Missouri-Kansas City Kansas City
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Robert J Nichols
Stanford University
Co-authored papers 1
Scott R VandenBerg
University of California san francisco
Co-authored papers 1
Christian Mirescu
Merck & Co. Inc.
Co-authored papers 1
Ala Trusina
Niels Bohr Institute, University of Copenhagen
Co-authored papers 1
Torsten Wittmann
University of California san francisco
Co-authored papers 1
Stewart Cooper
California Pacific Medical Center Research Institute
Co-authored papers 1
Molly FitzGibbon
University of California San Diego
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
Erik Verschueren
University of California San Francisco
Co-authored papers 1
Jayanta Debnath
University of California San Francisco
Co-authored papers 1
Eric J Huang
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Release 1.2