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Author Details

Linda Z Penn
University of Toronto
1990
132
62
PMIDPaper TitleJournal TitlePublished Year
37987734Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality.Cancer Res2023
35244724The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.Nucleic Acids Res2022
35768578Statins and prostate cancer-hype or hope? The biological perspective.Prostate Cancer Prostatic Dis2022
35732821Statins and prostate cancer-hype or hope? The epidemiological perspective.Prostate Cancer Prostatic Dis2022
35536872Bimodal Gene Expression in Patients with Cancer Provides Interpretable Biomarkers for Drug Sensitivity.Cancer Res2022
36280687Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins.Nat Commun2022
32665698The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.Leukemia2021
33602786Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced <i>N</i>-glycosylation Abundance and Branching.Cancer Res2021
33509943Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.Cancer Res2021
33617523Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.PLoS Comput Biol2021
33563030Quantitative Prostate MRI Analysis Following Fluvastatin Therapy for Localized Prostate Cancer - A Pilot Study.Can Assoc Radiol J2021
34188192MYC protein interactors in gene transcription and cancer.Nat Rev Cancer2021
34019286Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies.Methods Mol Biol2021
32620539The Suggested Unique Association Between the Various Statin Subgroups and Prostate Cancer.Eur Urol Focus2021
32203069A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.Prostate Cancer Prostatic Dis2020
32887721Statins as Anticancer Agents in the Era of Precision Medicine.Clin Cancer Res2020
32641738The deleterious association between proton pump inhibitors and prostate cancer-specific mortality - a population-based cohort study.Prostate Cancer Prostatic Dis2020
32749766Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death.Mol Oncol2020
31023626An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer.Mol Metab2019
31686052Multiple direct interactions of TBP with the MYC oncoprotein.Nat Struct Mol Biol2019
31350286Modelling the MYC-driven normal-to-tumour switch in breast cancer.Dis Model Mech2019
29229608Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins.Cancer Res2018
30158517MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.Nat Commun2018
30415952MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.Mol Cell2018
30300580MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.Cancer Cell2018
28587062MYC Deregulation in Primary Human Cancers.Genes (Basel)2017
30263178Association between depression, glycaemic control and the prevalence of diabetic retinopathy in a diabetic population in Cameroon.S Afr J Psychiatr2017
28806398Lysine-52 stabilizes the MYC oncoprotein through an SCF<sup>Fbxw7</sup>-independent mechanism.Oncogene2017
28806396Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth.Oncogene2017
27139377ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data.Genome Biol2016
27562463The interplay between cell signalling and the mevalonate pathway in cancer.Nat Rev Cancer2016
27267444MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation.Cell Cycle2016
24933113Myc and its interactors take shape.Biochim Biophys Acta2015
26353928Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.Oncotarget2015
28031882Guiding principles for a successful multidisciplinary research collaboration.Future Sci OA2015
25631767AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.Blood2015
25452129BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.J Proteomics2015
25609067Integrating RAS status into prognostic signatures for adenocarcinomas of the lung.Clin Cancer Res2015
23435422MYC activity is negatively regulated by a C-terminal lysine cluster.Oncogene2014
27308369Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one.Mol Cell Oncol2014
26217692BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors.Data Brief2014
25522242Identification of c-MYC SUMOylation by mass spectrometry.PLoS One2014
24994712Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.Cancer Res2014
24990622The role of ligand density and size in mediating quantum dot nuclear transport.Small2014
24337703Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells.Breast Cancer Res Treat2014
23359703Involvement of Toso in activation of monocytes, macrophages, and granulocytes.Proc Natl Acad Sci U S A2013
24006057Identifying Myc interactors.Methods Mol Biol2013
24030976MYC phosphorylation at novel regulatory regions suppresses transforming activity.Cancer Res2013
23699408Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.Genes Dev2013
23589495Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP.J Cell Biol2013
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Collaborators

Paul C Boutros
University of California los angeles
Co-authored papers 24
Igor Jurisica
Schroeder Arthritis Institute
Co-authored papers 20
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 14
Manpreet Kalkat
Van Andel Institute
Co-authored papers 13
Joseph Longo
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 12
David W Andrews
Sunnybrook Research Institute, University of Toronto
Co-authored papers 11
Corey Lourenco
University of Toronto
Co-authored papers 11
Amanda R Wasylishen
The University of Texas MD Anderson Cancer Center
Co-authored papers 10
Romina Ponzielli
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 10
Peter J Mullen
University of St Andrews
Co-authored papers 10
William B Tu
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 10
Fereshteh Khosravi
b Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 9
Aleksandra A Pandyra
Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf
Co-authored papers 8
James W Clendening
The Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto
Co-authored papers 8
Wendy Wei-Lynn Wong
Institute of Experimental Immunology, University of Zurich .
Co-authored papers 8
Pak-Kei Chan
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 8
Sam S Kim
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 6
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 6
Diana Resetca
University of Toronto
Co-authored papers 6
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 6
Angelina Stojanova
University of Toronto
Co-authored papers 6
Anna Martirosyan
West Virginia University
Co-authored papers 6
Maria Sunnerhagen
Linkoping University
Co-authored papers 6
Dharmendra Dingar
Montreal Heart Institute Montreal Quebec Canada.
Co-authored papers 6
Daniel Y L Mao
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 6
Carolyn A Goard
Princess Margaret Cancer Centre, Ontario Cancer Institute
Co-authored papers 5
Neil E Fleshner
University of Toronto
Co-authored papers 5
Melania Pintilie
Princess Margaret Cancer Centre, University Health Network
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Release 1.2