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Author Details

Christopher Dirk Keene
University of Washington
1998
239
50
PMIDPaper TitleJournal TitlePublished Year
37333251Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology.bioRxiv2024
37985223Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.Alzheimers Dement2024
37984853Sex-specific genetic architecture of late-life memory performance.Alzheimers Dement2024
35949106Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease.Brain2023
37953850Mapping the individual human cortex using multidimensional MRI and unsupervised learning.Brain Commun2023
37903257Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease.Proc Natl Acad Sci U S A2023
37624381Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2.Acta Neuropathol2023
37620363Cross-species comparative analysis of single presynapses.Sci Rep2023
37824669Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex.Science2023
37824655Transcriptomic cytoarchitecture reveals principles of human neocortex organization.Science2023
37824649Interindividual variation in human cortical cell type abundance and expression.Science2023
37645998Mapping Human Tissues with Highly Multiplexed RNA in situ Hybridization.bioRxiv2023
37605362Ferroptosis of Microglia in Aging Human White Matter Injury.Ann Neurol2023
37459083Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.JAMA Neurol2023
37059743A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease.Sci Data2023
37248328Human microglia show unique transcriptional changes in Alzheimer's disease.Nat Aging2023
37279935Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid.Clin Chem2023
37173305Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease.Nat Commun2023
37195467Performance of a condensed protocol to assess limbic-predominant age-related TDP-43 encephalopathy neuropathologic change.J Neuropathol Exp Neurol2023
37461624Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.medRxiv2023
36879321Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures.J Neuroinflammation2023
36692179The status of digital pathology and associated infrastructure within Alzheimer's Disease Centers.J Neuropathol Exp Neurol2023
36399262Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.Methods Mol Biol2023
36512061LATE-NC staging in routine neuropathologic diagnosis: an update.Acta Neuropathol2023
36870337The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia.Lancet Healthy Longev2023
36538112Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change.Acta Neuropathol2023
36732296Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change.Brain2023
36927167Alzheimer's Disease-Related Dementias Summit 2022: National Research Priorities for the Investigation of Post-Traumatic Brain Injury Alzheimer's Disease and Related Dementias.J Neurotrauma2023
34364650Traumatic Brain Injury and Risk of Neurodegenerative Disorder.Biol Psychiatry2022
35612774Association of cerebral microvascular dysfunction and white matter injury in Alzheimer's disease.Geroscience2022
35697880Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.Acta Neuropathol2022
35779466Reduced gene dosage is a common mechanism of neuropathologies caused by ATP6AP2 splicing mutations.Parkinsonism Relat Disord2022
35552371Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.Brain2022
36490316SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers.Proc Natl Acad Sci U S A2022
35997131Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.Mov Disord2022
36164936Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain.ASN Neuro2022
36343257Aβ and tau prions feature in the neuropathogenesis of Down syndrome.Proc Natl Acad Sci U S A2022
35319013Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse.Nature2022
35099792Mass Synaptometry: Applying Mass Cytometry to Single Synapse Analysis.Methods Mol Biol2022
34853071Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis.Cancer Res2022
35178571TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.Dis Model Mech2022
34992294Author Correction: Human neocortical expansion involves glutamatergic neuron diversification.Nature2022
34818016Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease.J Proteome Res2022
34813858Viable human brain microvessels for the study of aging and neurodegenerative diseases.Microvasc Res2022
34753215Spinal cord-predominant neuropathology in an adult-onset case of POLR3A-related spastic ataxia.Neuropathology2022
34482642Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain.Alzheimers Dement2022
32170790The application of in vitro-derived human neurons in neurodegenerative disease modeling.J Neurosci Res2021
33796061The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample.Front Neurol2021
33822070Association of Sex and Age With Mild Traumatic Brain Injury-Related Symptoms: A TRACK-TBI Study.JAMA Netw Open2021
33789096Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex.Cell Rep2021
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Collaborators

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Co-authored papers 77
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Co-authored papers 42
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University of Washington
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University of Washington School of Medicine
Co-authored papers 30
Allen Institute for Brain Science
Co-authored papers 16
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Co-authored papers 12
Indiana University School of Medicine
Co-authored papers 11
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Co-authored papers 11
Seattle Children's Hospital
Co-authored papers 11
University of Pennsylvania
Co-authored papers 11
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Co-authored papers 10
Allen Institute for Brain Science
Co-authored papers 10
University of Washington, USA Institute for Stem Cell and Regenerative Medicine
Co-authored papers 9
and Clinical Center
Co-authored papers 9
Co-authored papers 9
University of Pennsylvania
Co-authored papers 9
Co-authored papers 9
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 8
Uniformed Services University School of Medicine
Co-authored papers 8
Columbia University Medical Center
Co-authored papers 8
University of Washington
Co-authored papers 8
Allen Institute for Brain Science
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University of Kentucky
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