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Author Details

Brian E Krumm
University of North Carolina School of Medicine
2003
32
21
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36302898Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.Nat Chem Biol2023
37221270Structural genomics of the human dopamine receptor system.Cell Res2023
36906681Molecular mechanism of biased signaling at the kappa opioid receptor.Nat Commun2023
36087581Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.Neuron2022
35835867Inactive and active state structures template selective tools for the human 5-HT<sub>5A</sub> receptor.Nat Struct Mol Biol2022
36450989Molecular basis for selective activation of DREADD-based chemogenetics.Nature2022
34789874Structure, function and pharmacology of human itch GPCRs.Nature2021
33548201Structures of the human dopamine D3 receptor-G<sub>i</sub> complexes.Mol Cell2021
33571431Structural insights into the human D1 and D2 dopamine receptor signaling complexes.Cell2021
33750903Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.Cell Res2021
32367019TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.Nat Chem Biol2020
32946782Structure of a Hallucinogen-Activated Gq-Coupled 5-HT<sub>2A</sub> Serotonin Receptor.Cell2020
32123359A self-activating orphan receptor.Nature2020
32130889A Structural Understanding of Class B GPCR Selectivity and Activation Revealed.Structure2020
29307491Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.Cell2018
29752449Activation mechanisms for a universal signalling protein.Nature2018
28352119Identification of small molecule inhibitors of Interleukin-18.Sci Rep2017
27924846Structure and dynamics of a constitutively active neurotensin receptor.Sci Rep2016
25852552Peptide ligand recognition by G protein-coupled receptors.Front Pharmacol2015
26578811Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.Proc Natl Acad Sci U S A2015
26205105Structural prerequisites for G-protein activation by the neurotensin receptor.Nat Commun2015
26057800Crystallization of interleukin-18 for structure-based inhibitor design.Acta Crystallogr F Struct Biol Commun2015
24677376Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses.Protein Sci2014
22927815A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein.PLoS Pathog2012
21486005Gambogic acid, a natural product inhibitor of Hsp90.J Nat Prod2011
19781641The R1441C mutation alters the folding properties of the ROC domain of LRRK2.Biochim Biophys Acta2009
18602399Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.J Mol Biol2008
19104048Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein.Proc Natl Acad Sci U S A2008
17426153Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.Proc Natl Acad Sci U S A2007
16978643Structural and functional studies of EpsC, a crucial component of the type 2 secretion system from Vibrio cholerae.J Mol Biol2006
15532979Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin.Int J Med Microbiol2004
14556751Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae.J Mol Biol2003
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Collaborators

Bryan L Roth
UNC Chapel Hill School of Medicine
Co-authored papers 12
Xi-Ping Huang
University of North Carolina School of Medicine
Co-authored papers 6
Kuglae Kim
University of North Carolina School of Medicine
Co-authored papers 5
Xiangzhi Meng
University of California Los Angeles
Co-authored papers 5
Jonathan F Fay
University of North Carolina School of Medicine
Co-authored papers 5
Jeffrey F DiBerto
University of North Carolina at Chapel Hill
Co-authored papers 4
Ryan H Gumpper
UNC School of Medicine
Co-authored papers 4
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Bryan L Roth
UNC School of Medicine
Co-authored papers 3
Can Cao
University of North Carolina School of Medicine
Co-authored papers 3
Hualiang Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Co-authored papers 3
Christophe L M J Verlinde
University of Washington
Co-authored papers 2
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 2
David E Nichols
Eshelman School of Pharmacy, University of North Carolina
Co-authored papers 2
Michael J Robertson
Stanford University School of Medicine
Co-authored papers 2
Alpay B Seven
Stanford University School of Medicine
Co-authored papers 2
Petr Popov
Skolkovo Institute of Science and Technology
Co-authored papers 2
Georgios Skiniotis
Stanford University School of Medicine
Co-authored papers 2
Carl-Mikael Suomivuori
Stanford University School of Medicine
Co-authored papers 1
Marc A D??mgen
Stanford University
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Ron O Dror
Co-authored papers 1
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Timothy Cardozo
Co-authored papers 1
Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Gye Won Han
Bridge Institute, University of Southern California
Co-authored papers 1
Shicheng Zhang
University of North Carolina at Chapel Hill
Co-authored papers 1
Sheng Wang
University of North Carolina at Chapel Hill School of Medicine
Co-authored papers 1
Ouliana Panova
Stanford University School of Medicine, Stanford University
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