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Author Details

Stephen O'Rahilly
1983
499
126
PMIDPaper TitleJournal TitlePublished Year
36722378Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity.2023
37601970Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.Cell Genom2023
37659411High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor.2023
38092039GDF15 linked to maternal risk of nausea and vomiting during pregnancy.2023
38087113Academic clinician-scientists risk becoming an endangered species.2023
37339320Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty.J Clin Endocrinol Metab2023
37398065Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy.2023
36693378Loci for insulin processing and secretion provide insight into type 2 diabetes risk.Am J Hum Genet2023
37116469Cachexia: A systemic consequence of progressive, unresolved disease.2023
36722855A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.2023
34875679Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution.Journal of Clinical Endocrinology and Metabolism2022
35796717The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.journal of applied laboratory medicine, The2022
35675318Reply to G Taubes, MI Friedman, and V Torres-Carot et al.American Journal of Clinical Nutrition2022
36064109Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice.Molecular Metabolism2022
35920656Describing the natural history of clinical, biochemical and radiological outcomes of children with familial partial lipodystrophy type 2 (FPLD2) from the United Kingdom: A retrospective case series.Clinical Endocrinology2022
35976089Reference ranges for GDF-15, and risk factors associated with GDF-15, in a large general population cohort.Clin Chem Lab Med2022
36530175Damaging missense variants in implicate a role for IGF-1 resistance in the etiology of type 2 diabetes.2022
35134825The energy balance model of obesity: beyond calories in, calories out.American Journal of Clinical Nutrition2022
34475432Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.Scientific Reports2021
34297931The islet's bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies.Cell2021
33691105Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion.Cell Reports2021
33901270Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance.J Clin Endocrinol Metab2021
33846642Colchicine-an old dog with new tricks.Nature Metabolism2021
34045736Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.Nat Med2021
34210869Finding genes that control body weight.Science2021
33831374The islet's bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies.Cell2021
33510216Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells.Scientific Reports2021
33932335Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study.Lancet Diabetes and Endocrinology,The2021
33826913Obesity therapeutics: The end of the beginning.2021
34187898Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.Proceedings of the National Academy of Sciences of the United States of America2021
33355307Treasure Your Exceptions-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture.2021
33242659A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes.Molecular Metabolism2021
34732894MC3R links nutritional state to childhood growth and the timing of puberty.Nature2021
34819667Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.Nature2021
34648354Mapping the proteo-genomic convergence of human diseases.Science2021
32838359When Two Pandemics Meet: Why Is Obesity Associated with Increased COVID-19 Mortality?Med2020
31853550GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement.Journal of Clinical Endocrinology and Metabolism2020
32310257GDF15: A Hormone Conveying Somatic Distress to the Brain.Endocrine Reviews2020
32051582Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.Nature2020
31875646GDF15 mediates the effects of metformin on body weight and energy balance.Nature2020
32392278Leptin-Mediated Changes in the Human Metabolome.J Clin Endocrinol Metab2020
32492392Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.Cell Metab2020
32439336Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.Mol Metab2020
32640247Constitutional Thinness: tALKing the tALK or wALKing the wALK?2020
32694841The wasting hormone GDF15 frees up fat to fight infection.Nature Metabolism2019
31801546Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome.Journal of Translational Medicine2019
31666564Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.Scientific Reports2019
29360107Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.Sci Data2018
30408605European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale.Contemporary Clinical Trials2018
29980761GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity.Int J Obes (Lond)2018
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William Harvey Research Institute, Queen Mary University of London
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King's College London
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