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Author Details

Stephanos Ioannidis
H3 Biomedicine Inc.
2008
26
16
PMIDPaper TitleJournal TitlePublished Year
34636321USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.Elife2021
33600552Correction: The deubiquitylase USP9X controls ribosomal stalling.J Cell Biol2021
33507233The deubiquitylase USP9X controls ribosomal stalling.J Cell Biol2021
32551016Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.ACS Med Chem Lett2020
33488969Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.ACS Med Chem Lett2020
32017919Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.Cell Chem Biol2020
32636217USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.Life Sci Alliance2020
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
29301085Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.J Med Chem2018
29045389Molecular basis of USP7 inhibition by selective small-molecule inhibitors.Nature2017
25815142Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.ACS Med Chem Lett2015
26546219Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.Bioorg Med Chem Lett2015
24359159Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.J Med Chem2014
24881567Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.Bioorg Med Chem Lett2014
23562594Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.Bioorg Med Chem Lett2013
22551018Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.J Med Chem2012
24900538Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.ACS Med Chem Lett2012
21138246Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.J Med Chem2011
21493067In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.Bioorg Med Chem Lett2011
20144546Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors.Bioorg Med Chem Lett2010
19097792Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.Bioorg Med Chem Lett2009
19857966Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.Bioorg Med Chem Lett2009
19962667The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.Cancer Cell2009
18694641Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.Bioorg Med Chem Lett2008
18547806Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.Bioorg Med Chem Lett2008
18775810Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.J Biol Chem2008
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Nancy Su
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Thomas W Gero
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Co-authored papers 4
Sunkyu Kim
Korea University
Co-authored papers 4
Terry MacIntyre
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Martin Wild
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Steven W Criscione
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Kathleen Burke
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Ricky W Johnstone
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Edward J Hennessy
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Areya Tabatabai
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Andrea Newbold
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Srividya B Balachander
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Elizabeth A Coker
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Release 1.2