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Author Details

David M Lewinsohn
Oregon Health and Science University
1986
149
54
PMIDPaper TitleJournal TitlePublished Year
37231163Divergent metabolic programmes control two populations of MAIT cells that protect the lung.Nat Cell Biol2023
38003817Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis.Pathogens2023
37693580Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis.Res Sq2023
37693561Modulation of riboflavin biosynthesis and utilization in mycobacteria.bioRxiv2023
37275871Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with <i>Mycobacterium tuberculosis</i>.Front Immunol2023
35149285Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies.EBioMedicine2022
35493495The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell.Front Immunol2022
35428268Cascade Immune Mechanisms of Protection against Mycobacterium tuberculosis (IMPAc-TB): study protocol for the Household Contact Study in the Western Cape, South Africa.BMC Infect Dis2022
36581641Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.Sci Rep2022
36085311Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive.Commun Biol2022
33360378T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells.Mol Immunol2021
33828558Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting.Front Immunol2021
33897687MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection.Front Immunol2021
35164552Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence.mBio2021
34740474Donor Unrestricted T Cells: Linking innate and adaptive immunity.Vaccine2021
33951066Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.PLoS One2021
32568415The MAIT TCRβ chain contributes to discrimination of microbial ligand.Immunol Cell Biol2020
32014117The status of tuberculosis vaccine development.Lancet Infect Dis2020
31792826Generation of MR1-Restricted T Cell Clones by Limiting Dilution Cloning of MR1 Tetramer<sup>+</sup> Cells.Methods Mol Biol2020
31763996Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs.J Clin Invest2020
33042140Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans.Front Immunol2020
32963314Alternative splicing of MR1 regulates antigen presentation to MAIT cells.Sci Rep2020
32817339Atypical TRAV1-2[-] T cell receptor recognition of the antigen-presenting molecule MR1.J Biol Chem2020
32699177Correction: Quantitative and Qualitative Perturbations of CD8<sup>+</sup> MAITs in Healthy <i>Mycobacterium tuberculosis</i>-Infected Individuals.Immunohorizons2020
32983150Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments.Front Immunol2020
32582206Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses.Front Immunol2020
32341160Ligand-dependent downregulation of MR1 cell surface expression.Proc Natl Acad Sci U S A2020
32499216Quantitative and Qualitative Perturbations of CD8<sup>+</sup> MAITs in Healthy <i>Mycobacterium tuberculosis</i>-Infected Individuals.Immunohorizons2020
32267943Peripheral Blood Mucosal-Associated Invariant T Cells in Tuberculosis Patients and Healthy Mycobacterium tuberculosis-Exposed Controls.J Infect Dis2020
30335466Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.Am J Respir Crit Care Med2019
31731979New Concepts in Tuberculosis Host Defense.Clin Chest Med2019
31611259MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria.J Immunol2019
31231693TRAV1-2<sup>+</sup> CD8<sup>+</sup> T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.Commun Biol2019
31250810New hope for tuberculosis vaccines.Lancet Infect Dis2019
31099768Tuberculosis Screening, Testing, and Treatment of U.S. Health Care Personnel: Recommendations from the National Tuberculosis Controllers Association and CDC, 2019.MMWR Morb Mortal Wkly Rep2019
30923183Recognition of CD8<sup>+</sup> T-cell epitopes to identify adults with pulmonary tuberculosis.Eur Respir J2019
31040086Harnessing donor unrestricted T-cells for new vaccines against tuberculosis.Vaccine2019
30886396MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens.Sci Rep2019
30789961Casting a wider net: Immunosurveillance by nonclassical MHC molecules.PLoS Pathog2019
29451704MAIT cells and microbial immunity.Immunol Cell Biol2018
30021818Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.Clin Microbiol Rev2018
29940408Role of MAIT cells in pulmonary bacterial infection.Mol Immunol2018
30071544Diagnostic Challenge of Tuberculosis Heterogeneity.Semin Respir Crit Care Med2018
30205969Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis.Tuberculosis (Edinb)2018
29904578Early clearance versus control: what is the meaning of a negative tuberculin skin test or interferon-gamma release assay following exposure to <i>Mycobacterium tuberculosis</i>?F1000Res2018
30006464MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.Sci Immunol2018
30514508Characterization of specific CD4 and CD8 T-cell responses in QuantiFERON TB Gold-Plus TB1 and TB2 tubes.Tuberculosis (Edinb)2018
30449535MR1-dependent antigen presentation.Semin Cell Dev Biol2018
29356555Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells.Am J Respir Cell Mol Biol2018
29661928Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine.Infect Immun2018
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Collaborators

Oregon Health and Science University
Co-authored papers 50
Oregon Health and Science University
Co-authored papers 23
Oregon Health and Science University
Co-authored papers 16
Oregon Health and Science University
Co-authored papers 15
Oregon Health and Science University
Co-authored papers 9
Case Western Reserve University and University Hospitals Cleveland Medical Center
Co-authored papers 8
Case Western Reserve University
Co-authored papers 7
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Co-authored papers 6
University of Oklahoma Health Sciences Center
Co-authored papers 6
Oregon Health & Science University
Co-authored papers 4
Busitema University
Co-authored papers 4
University of Washington
Co-authored papers 4
College of Medicine, University of Arizona
Co-authored papers 4
Portland VA Medical Center, 3710 U.S. Veterans Hospital Road
Co-authored papers 3
University of Washington
Co-authored papers 3
Tuberculosis Research Unit, Case Western Reserve University School of Medicine
Co-authored papers 3
Oregon Health and Science University
Co-authored papers 3
University of Washington School of Medicine
Co-authored papers 3
Pacific Northwest National Laboratory
Co-authored papers 2
Pacific Northwest National Laboratory
Co-authored papers 2
St. Jude Children's Research Hospital
Co-authored papers 2
Oregon Health & Science University, University of California Berkeley
Co-authored papers 2
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 2
Case Western Reserve University
Co-authored papers 2
School of Public Health, Makerere University
Co-authored papers 2
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Pacific Northwest National Laboratory
Co-authored papers 2
Texas Biomedical Research Institute
Co-authored papers 2
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 2
Co-authored papers 2