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Author Details

Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
1999
82
51
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37591465Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.Neurobiol Dis2023
34981791Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.J Clin Invest2022
35413950Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.Nat Commun2022
33715827Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.Biol Psychiatry2022
34368631Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats.J Alzheimers Dis Rep2021
33854069Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.Nat Commun2021
33852912Reducing acetylated tau is neuroprotective in brain injury.Cell2021
34851693AD-linked R47H-<i>TREM2</i> mutation induces disease-enhancing microglial states via AKT hyperactivation.Sci Transl Med2021
33054973A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.Elife2020
31906970Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.Mol Neurodegener2020
31873194Microglial microRNAs mediate sex-specific responses to tau pathology.Nat Neurosci2020
31945125Astrocyte senescence promotes glutamate toxicity in cortical neurons.PLoS One2020
33312721Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer's disease.Transl Neurosci2020
30617321An exercise-induced messenger boosts memory in Alzheimer's disease.Nat Med2019
31640778Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.Acta Neuropathol Commun2019
32096027Regulation of Tau Homeostasis and Toxicity by Acetylation.Adv Exp Med Biol2019
31542321Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.Neuron2019
31226473Rabies virus glycoprotein (RVG29)-linked microRNA-124-loaded polymeric nanoparticles inhibit neuroinflammation in a Parkinson's disease model.Int J Pharm2019
31367015Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.Nat Genet2019
30735499Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.PLoS Biol2019
31171460Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?Trends Mol Med2019
29028540Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.Curr Opin Neurobiol2018
30053424The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.Cell2018
30232263Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.Proc Natl Acad Sci U S A2018
30258237Converging pathways in neurodegeneration, from genetics to mechanisms.Nat Neurosci2018
29924488Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.Curr Protoc Cell Biol2018
30510490Serum miR-146a and miR-150 as Potential New Biomarkers for Hip Fracture-Induced Acute Lung Injury.Mediators Inflamm2018
30415806Military-related risk factors for dementia.Alzheimers Dement2018
29753269Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.Curr Opin Neurobiol2018
29551491Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.Neuron2018
29522838Region-specific differences in bioenergetic proteins and protein response to acute high fat diet in brains of low and high capacity runner rats.Neurosci Lett2018
29518360TREM2 and Amyloid Beta: A Love-Hate Relationship.Neuron2018
28972160An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.J Biol Chem2017
28438992Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Proc Natl Acad Sci U S A2017
28083916Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.Bioessays2017
28404863Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Sci Transl Med2017
28155818Fate of Neural Progenitor Cells Transplanted Into Jaundiced and Nonjaundiced Rat Brains.Cell Transplant2017
28966121Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.Stem Cell Reports2017
29124108An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from <i>GRN</i> gene mutations.Alzheimers Dement (N Y)2017
29198827Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.Stem Cell Reports2017
27100611Targeting microglia for the treatment of Alzheimer's Disease.Glia2016
27356871Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.Mol Neurodegener2016
27246804Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.Glia2016
27041503Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.Neuron2016
26828300Study of breakthrough cancer pain in an animal model induced by endothelin-1.Neurosci Lett2016
25589773SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.J Neurosci2015
26273137The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture.Mediators Inflamm2015
26390242Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.Nat Med2015
26206194Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.Biochem Pharmacol2015
25705859Significance of Serum mtDNA Concentration in Lung Injury Induced by Hip Fracture.Shock2015
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Gladstone Institutes
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Gladstone Institutes
Co-authored papers 16
Lennart Mucke
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Co-authored papers 12
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Buck Institute for Research on Aging
Co-authored papers 12
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Harvard Medical School
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National Institute of Neurological, National Institutes of Health (NIH)
Co-authored papers 10
Peter Dongmin Sohn
Gladstone Institutes
Co-authored papers 10
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Dokkyo Medical University
Co-authored papers 9
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Gladstone Institutes
Co-authored papers 9
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UCSF Weill Institute for Neurosciences, University of California san francisco
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Gladstone Institutes
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Co-authored papers 5
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Harvard T.H. Chan School of Public Health
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Giovanni Coppola
David Geffen School of Medicine, University of California los angeles
Co-authored papers 4
Sue-Ann Mok
University of Alberta
Co-authored papers 4
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 3
Steven Finkbeiner
J. David Gladstone Institutes
Co-authored papers 3
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Mehrdad Shamloo
Stanford University School of Medicine
Co-authored papers 2
Anna Karydas
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Tejal A Desai
University of California San Francisco
Co-authored papers 2
Nino Devidze
Gladstone Institute of Neurological Disease
Co-authored papers 2
Shiaoching Gong
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Release 1.2