Author details

Full Name

Hiroyuki Mano

Affiliation

ORCID

Career Start Year

1970

Papers

333

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37099440	A new era of the Asian clinical research network: a report from the ATLAS international symposium.	Jpn J Clin Oncol	2023
35906852	Dramatic response to entrectinib in a patient with malignant peripheral nerve sheath tumor harboring novel SNRNP70-NTRK3 fusion gene.	Genes Chromosomes and Cancer	2023
36442478	High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer.	Molecular Cancer Therapeutics	2023
36404139	Cells with stem-like properties are associated with the development of HPV18-positive cervical cancer.	Cancer Science	2023
37596408	Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers.	Br J Cancer	2023
37592448	Extensive analysis of 59 sarcoma-related fusion genes identified pazopanib as a potential inhibitor to COL1A1-PDGFB fusion gene.		2023
37819940	Phase 2 trial of nivolumab in metastatic rare cancer with dMMR or MSI-H and relation with immune phenotypic analysis (the ROCK trial).		2023
38073632	Case report and literature review: exploration of molecular therapeutic targets in recurrent malignant meningioma through comprehensive genetic analysis with Todai OncoPanel.		2023
38071343	Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia.		2023
37479138	Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland.	Lab Invest	2023
37133223	The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan.		2023
37067535	The pathogenic role of the BRCA2 c.7847C>T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition.		2023
36732592	Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.		2023
36601953	Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.	Cancer Sci	2023
36919757	Molecular pathology quality control in Southeast Asia: Results of a multiregional quality assurance study from MASTER KEY Asia.		2023
35343095	Exploration of predictive biomarkers for postoperative recurrence of stage II/III colorectal cancer using genomic sequencing.	Cancer Medicine	2022
36166639	Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.	Cancer Research	2022
35579198	Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies.	Cancer Sci	2022
36277904	Primary Intracranial Spindle Cell Sarcoma, -Mutant, with Amplification Diagnosed on the Basis of Extensive Molecular Profiling.	Clinical Medicine Insights: Case Reports	2022
36333410	Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling.	NPJ Precis Oncol	2022
35482395	Tumor mutational burden measurement using comprehensive genomic profiling assay.	Japanese Journal of Clinical Oncology	2022
36321305	C-CAT: The National Datacenter for Cancer Genomic Medicine in Japan.	Cancer Discovery	2022
36923281	Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration.		2022
34687740	HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.	Gastroenterology	2022
35039617	Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.	Scientific Reports	2022
35255903	Genetic diagnosis of pseudomyxoma peritonei originating from mucinous borderline tumor inside an ovarian teratoma.	BMC Medical Genomics	2022
35254400	Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti-PD-1 Therapy.	Clinical Cancer Research	2022
34911818	Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non-small Cell Lung Cancer PDX Models with Driver Genetic Alterations.	Molecular Cancer Therapeutics	2022
35108529	PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted TÂ cell clonotypes.	Cell Reports	2022
35090594	Lactic acid promotes PD-1 expression in regulatory TÂ cells in highly glycolytic tumor microenvironments.	Cancer Cell	2022
34695176	Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations.	Blood	2022
35304574	Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.	Oncogene	2022
35199052	Composite Clonal Analysis Reveals Transition of NSCLC Subtypes Through Accumulation of Gene Mutations: A Case Report.	JTO Clinical and Research Reports	2022
35344043	HSP90 Inhibition Overcomes Resistance to Molecular Targeted Therapy in BRAFV600E-mutant High-grade Glioma.	Clinical Cancer Research	2022
35121863	Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities.	Nature Cancer	2021
32472275	Safety and usefulness of endoscopic submucosal dissection for early esophageal cancers in elderly patients aged 80Â years or older.	Esophagus	2021
33484069	Development of an optimal protocol for molecular profiling of tumor cells in pleural effusions at single-cell level.	Cancer Science	2021
34272467	Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.	npj Precision Oncology	2021
34158601	Comprehensive molecular profiling of pulmonary pleomorphic carcinoma.	npj Precision Oncology	2021
34000301	Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.	Journal of Biological Chemistry	2021
33782572	Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels.	Nature Biomedical Engineering	2021
33444924	Comprehensive molecular and clinicopathological profiling of desmoid tumours.	European Journal of Cancer	2021
33926917	A Low Tumor Mutational Burden and Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors.	Clinical Cancer Research	2021
33870130	Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution.	iScience	2021
33761896	EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells.	BMC Cancer	2021
33759313	Characterization of the large-scale Japanese patient-derived xenograft (J-PDX) library.	Cancer Science	2021
34310819	Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers.	Cancer Science	2021
32654197	Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus.	Histopathology	2021
33196586	Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma.	Clinical Orthopaedics and Related Research	2021
33395611	Extensive functional evaluation of exon 20 insertion mutations of EGFR.	Lung Cancer	2021