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Author Details

Diane Joseph-McCarthy
Boston University
1987
75
33
PMIDPaper TitleJournal TitlePublished Year
36862685Machine learning for the identification of respiratory viral attachment machinery from sequences data.PLoS One2023
37112765Vaccines Alone Cannot Slow the Evolution of SARS-CoV-2.Vaccines (Basel)2023
36530725No magic bullet: Limiting in-school transmission in the face of variable SARS-CoV-2 viral loads.Front Public Health2022
34799659Controlling long-term SARS-CoV-2 infections can slow viral evolution and reduce the risk of treatment failure.Sci Rep2021
33909660Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein.PLoS One2021
34818335Rapid relaxation of pandemic restrictions after vaccine rollout favors growth of SARS-CoV-2 variants: A model-based analysis.PLoS One2021
29931092Japan-United States of America Harmonized Assessment by Randomized Multicentre Study of OrbusNEich's Combo StEnt (Japan-USA HARMONEE) study: primary results of the pivotal registration study of combined endothelial progenitor cell capture and drug-eluting stent in patients with ischaemic coronary disease and non-ST-elevation acute coronary syndrome.Eur Heart J2018
28923873An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections.Antimicrob Agents Chemother2017
25948407Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.BMJ Open2015
26542501A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial.Am Heart J2015
26176600Evaluating Free Energies of Binding and Conservation of Crystallographic Waters Using SZMAP.J Chem Inf Model2015
24490951Fragment-based lead discovery and design.J Chem Inf Model2014
24881672Ensemble-based docking using biased molecular dynamics.J Chem Inf Model2014
22869295Virtual fragment screening: exploration of MM-PBSA re-scoring.J Comput Aided Mol Des2012
23043329Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).J Med Chem2012
22908966In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound.ACS Chem Biol2012
21315207A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial.Am Heart J2011
21982657A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction.Am Heart J2011
20666458Identification and characterization of acidic mammalian chitinase inhibitors.J Med Chem2010
19286091Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study.Lancet2009
19565336Challenges of fragment screening.J Comput Aided Mol Des2009
19495993Virtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide.J Comput Aided Mol Des2009
19241384Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.Protein Sci2009
18411262Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.J Biol Chem2008
18783200Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.J Med Chem2008
18798205Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.ChemMedChem2008
18465849Investigation of MM-PBSA rescoring of docking poses.J Chem Inf Model2008
18612831CONFIRM: connecting fragments found in receptor molecules.J Comput Aided Mol Des2008
17064892Identification of potent and selective TACE inhibitors via the S1 pocket.Bioorg Med Chem Lett2007
17956269Structure-based optimization of PKCtheta inhibitors.Biochem Soc Trans2007
17606376Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.Bioorg Med Chem2007
17531482Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.Bioorg Med Chem Lett2007
17554852Lead optimization via high-throughput molecular docking.Curr Opin Drug Discov Devel2007
17705360Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.J Med Chem2007
17657565Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.J Comput Aided Mol Des2007
17715908Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.J Med Chem2007
17336064Probing acid replacements of thiophene PTP1B inhibitors.Bioorg Med Chem Lett2007
16303309Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.Bioorg Med Chem2006
16806920Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.Bioorg Med Chem Lett2006
165455641,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.Bioorg Med Chem Lett2006
16335920Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.J Med Chem2005
16215511A helpline for patients with chronic dermatological conditions.Br J Nurs2005
16209958The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics.Am Heart J2005
14684293Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.Bioorg Med Chem Lett2004
15566296Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.J Med Chem2004
15464679Optimal duration of eptifibatide infusion in percutaneous coronary intervention (an ESPRIT substudy).Am J Cardiol2004
15364937Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).J Biol Chem2004
12660987Pharmacophore-based molecular docking to account for ligand flexibility.Proteins2003
12972102Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).Am J Cardiol2003
14643356Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.Bioorg Med Chem Lett2003
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Collaborators

Harvard University
Co-authored papers 8
Co-authored papers 6
Duke University
Co-authored papers 5
Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University
Co-authored papers 5
Duke University Medical Center
Co-authored papers 4
From the National Institutes of Health
Co-authored papers 3
Schrodinger Inc.
Co-authored papers 3
Lilly Research Laboratories
Co-authored papers 3
Universidade Federal de Sao Paulo
Co-authored papers 2
Co-authored papers 2
Albert Einstein College of Medicine
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Broad Institute
Co-authored papers 1
Brody School of Medicine, East Carolina University
Co-authored papers 1
University of Maryland School of Medicine, University of Maryland
Co-authored papers 1
Co-authored papers 1
University of California san francisco
Co-authored papers 1
University of Kentucky
Co-authored papers 1
Duke University School of Medicine
Co-authored papers 1
Co-authored papers 1
Fox Chase Cancer Center
Co-authored papers 1
Duke University School of Medicine
Co-authored papers 1
Geisel School of Medicine at Dartmouth
Co-authored papers 1
Stanford University Medical School
Co-authored papers 1
Vanderbilt University Medical Center
Co-authored papers 1
E-Da Hospital, College of Medicine, I-Shou University
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
Oncology R&D
Co-authored papers 1
University of Illinois at Urbana-Champaign
Co-authored papers 1