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Author Details

Kevin R Coombes
Medical College of Georgia
1990
203
59
PMIDPaper TitleJournal TitlePublished Year
37131792Transcriptome Complexity Disentangled: A Regulatory Molecules Approach.bioRxiv2024
36715691Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration.Cancer Discov2023
37023372Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.Blood2023
36216587Sequences of Events from the Electronic Medical Record and the Onset of Infection.Chem Biodivers2022
36250792CEDA: integrating gene expression data with CRISPR-pooled screen data identifies essential genes with higher expression.Bioinformatics2022
35966389<i>SITH:</i> An R package for visualizing and analyzing a spatial model of intratumor heterogeneity.Comput Syst Oncol2022
34601554RCytoGPS: an R package for reading and visualizing cytogenetics data.Bioinformatics2021
33515233Mercator: a pipeline for multi-method, unsupervised visualization and distance generation.Bioinformatics2021
33648439Pattern recognition in lymphoid malignancies using CytoGPS and Mercator.BMC Bioinformatics2021
33707228DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia.Genome Res2021
33862229Simulation-derived best practices for clustering clinical data.J Biomed Inform2021
33750375A novel model to label delirium in an intensive care unit from clinician actions.BMC Med Inform Decis Mak2021
32483590Unsupervised machine learning and prognostic factors of survival in chronic lymphocytic leukemia.J Am Med Inform Assoc2020
31794247Explaining Gene Expression Using Twenty-One MicroRNAs.J Comput Biol2020
33059160CytoGPS: A large-scale karyotype analysis of CML data.Cancer Genet2020
33110146Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model.Sci Rep2020
32554930LC-FACSeq is a method for detecting rare clones in leukemia.JCI Insight2020
30408569Co-Expression Analysis Reveals Mechanisms Underlying the Varied Roles of NOTCH1 in NSCLC.J Thorac Oncol2019
31861985A protocol to evaluate RNA sequencing normalization methods.BMC Bioinformatics2019
31582354Time-to-progression after front-line fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy for chronic lymphocytic leukaemia: a retrospective, multicohort study.Lancet Oncol2019
31292113Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia.Blood2019
31263896CytoGPS: a web-enabled karyotype analysis tool for cytogenetics.Bioinformatics2019
31105032LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML.EBioMedicine2019
31161200Inferring clonal heterogeneity in cancer using SNP arrays and whole genome sequencing.Bioinformatics2019
30563911Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.Genome Res2019
30689715Inferring clonal heterogeneity in cancer using SNP arrays and whole genome sequencing.Bioinformatics2019
29310570Thresher: determining the number of clusters while removing outliers.BMC Bioinformatics2018
30017829Proteogenomic Analysis of Surgically Resected Lung Adenocarcinoma.J Thorac Oncol2018
29881252Decomposing the Apoptosis Pathway Into Biologically Interpretable Principal Components.Cancer Inform2018
29976738Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways.Haematologica2018
30305013Thirty biologically interpretable clusters of transcription factors distinguish cancer type.BMC Genomics2018
29681454Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.Cell2018
29624814eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.Cancer Sci2018
29506475IntLIM: integration using linear models of metabolomics and gene expression data.BMC Bioinformatics2018
29505696Histone Modification Patterns Using RPPA-Based Profiling Predict Outcome in Acute Myeloid Leukemia Patients.Proteomics2018
27573556Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.Leukemia2017
28412730The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.Oncotarget2017
28165654Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer.Cancer Sci2017
28270436Focal Adhesion Kinase as a Potential Target in AML and MDS.Mol Cancer Ther2017
28185526Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.Leuk Lymphoma2017
29560090Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention.Oncotarget2017
28538184Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.Cell Rep2017
27885271p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status.Leukemia2017
27542854Genetic variants in thyroid cancer distant metastases.Endocr Relat Cancer2016
26420858A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition.Clin Cancer Res2016
26256940Atorvastatin for the Prophylaxis of Acute Graft-versus-Host Disease in Patients Undergoing HLA-Matched Related Donor Allogeneic Hematopoietic Stem Cell Transplantation (allo-HCT).Biol Blood Marrow Transplant2016
27663479Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer.Semin Oncol2016
27480147The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer.J Clin Oncol2016
27199546Selecting Reliable mRNA Expression Measurements Across Platforms Improves Downstream Analysis.Cancer Inform2016
27533304Risk Factors of <sup>131</sup>I-Induced Salivary Gland Damage in Thyroid Cancer Patients.J Clin Endocrinol Metab2016
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Collaborators

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Co-authored papers 35
The University of Texas MD Anderson Cancer Center
Co-authored papers 30
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 20
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University of Texas Southwestern Medical Center at Dallas
Co-authored papers 19
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 16
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Co-authored papers 14
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Co-authored papers 9
Co-authored papers 8
Co-authored papers 8
The University of Texas MD Anderson Cancer Center
Co-authored papers 8
Co-authored papers 7
Co-authored papers 7
National Cancer Institute (NCI)
Co-authored papers 6
The University of Texas MD Anderson Cancer Center
Co-authored papers 6
Yale School of Medicine
Co-authored papers 5
Co-authored papers 5
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
Co-authored papers 5
University of Texas at San Antonio
Co-authored papers 5
Tokyo University of Science
Co-authored papers 5
Co-authored papers 5
Co-authored papers 5
University of California San Diego
Co-authored papers 4
Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
Co-authored papers 4
Elsevier Inc.
Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
University of Texas MD Anderson Cancer Center
Co-authored papers 4
Institute for Informatics, Washington University School of Medicine in St. Louis
Co-authored papers 4
University of California San Diego
Co-authored papers 4