Author details

Full Name

Alykhan F Shamji

Affiliation

Center for the Science of Therapeutics, Broad Institute

ORCID

Career Start Year

1999

Papers

H Index

Expertise

CM4AI Collaborator

Nevan J Krogan (CM4AI)

PMID	Paper Title	Journal Title	Published Year
34124936	The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4<sup>+</sup> T Cells via a Novel CDK8-GATA3-FOXP3 Pathway.	Mol Cell Biol	2021
34124936	The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4<sup>+</sup> T Cells via a Novel CDK8-GATA3-FOXP3 Pathway.	Mol Cell Biol	2021
31461650	Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.	Cell Rep	2019
31461650	Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.	Cell Rep	2019
30046103	Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.	Nature	2018
30046103	Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.	Nature	2018
28805801	Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.	Nat Chem Biol	2017
28678785	Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.	Nature	2017
28805801	Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.	Nat Chem Biol	2017
28327978	A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay.	Gigascience	2017
29073062	Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.	Proc Natl Acad Sci U S A	2017
29195078	A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.	Cell	2017
28327978	A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay.	Gigascience	2017
29195078	A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.	Cell	2017
29073062	Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.	Proc Natl Acad Sci U S A	2017
28678785	Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.	Nature	2017
27109210	A genetic basis for the variation in the vulnerability of cancer to DNA damage.	Nat Commun	2016
27109210	A genetic basis for the variation in the vulnerability of cancer to DNA damage.	Nat Commun	2016
26928769	High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.	Nat Biotechnol	2016
27012813	DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.	Clin Cancer Res	2016
27329820	Integrated genetic and pharmacologic interrogation of rare cancers.	Nat Commun	2016
27224444	Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.	ACS Chem Biol	2016
26656090	Correlating chemical sensitivity and basal gene expression reveals mechanism of action.	Nat Chem Biol	2016
26656089	Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.	Nat Chem Biol	2016
27774134	Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.	ACS Med Chem Lett	2016
26656090	Correlating chemical sensitivity and basal gene expression reveals mechanism of action.	Nat Chem Biol	2016
26656089	Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.	Nat Chem Biol	2016
27774134	Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.	ACS Med Chem Lett	2016
27329820	Integrated genetic and pharmacologic interrogation of rare cancers.	Nat Commun	2016
27224444	Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.	ACS Chem Biol	2016
27012813	DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.	Clin Cancer Res	2016
26928769	High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.	Nat Biotechnol	2016
25501949	Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.	Cancer Discov	2015
25501949	Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.	Cancer Discov	2015
25660025	Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.	Cell Rep	2015
25860544	Discovery of a Small-Molecule Probe for V-ATPase Function.	J Am Chem Soc	2015
25968887	KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.	Cancer Res	2015
26482930	Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.	Cancer Discov	2015
26046436	Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.	Cell	2015
25998054	The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.	Elife	2015
26375002	Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.	Nature	2015
26195741	Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.	Proc Natl Acad Sci U S A	2015
26488816	Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.	Immunity	2015
26488816	Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.	Immunity	2015
26482930	Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.	Cancer Discov	2015
26375002	Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.	Nature	2015
26046436	Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.	Cell	2015
26195741	Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.	Proc Natl Acad Sci U S A	2015
25860544	Discovery of a Small-Molecule Probe for V-ATPase Function.	J Am Chem Soc	2015
25968887	KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.	Cancer Res	2015

1 - 50 of 116

Aurelien Dugourd

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University

Career Start Year 2016

Number of shared co-authors 3

Wail Ba-Alawi

Princess Margaret Cancer Centre, University Health Network, University Ave.

Career Start Year 2013

Number of shared co-authors 0

Nehme El-Hachem

Centre Hospitalier Universitaire Sainte-Justine Research Centre

Career Start Year 2011

Number of shared co-authors 0

Frederick S Vizeacoumar

College of Medicine, University of Saskatchewan

Career Start Year 2010

Number of shared co-authors 0

Murat Iskar

Friedrich Miescher Institute for Biomedical Research

Career Start Year 2010

Number of shared co-authors 0

Saurabh Mendiratta

University of Texas Southwestern Medical Center

Career Start Year 2009

Number of shared co-authors 3

Andrew T Magis

Institute for Systems Biology

Career Start Year 2007

Number of shared co-authors 0

Wenwei Lin

St. Jude Children's Research Hospital

Career Start Year 2007

Number of shared co-authors 1

Malia B Potts

St. Jude Children's Research Hospital

Career Start Year 2004

Number of shared co-authors 2

Nicholas A Graham

University of Southern California

Career Start Year 2004

Number of shared co-authors 1

Aik Choon Tan

Huntsman Cancer Institute, The University of Utah

Career Start Year 2003

Number of shared co-authors 0

Xiaohu Zhang

National Center for Advancing Translational Sciences

Career Start Year 2003

Number of shared co-authors 0

Luke L Lairson

The Scripps Research Institute

Career Start Year 2003

Number of shared co-authors 3

Anang A Shelat

St. Jude Children's Research Hospital

Career Start Year 2003

Number of shared co-authors 2

Noel Southall

National Center for Advancing Translational Sciences, National Institutes of Health

Career Start Year 2002

Number of shared co-authors 6

Susanne Heynen-Genel

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute

Career Start Year 2002

Number of shared co-authors 1

Craig J Thomas

Center for Cancer Research, National Cancer Institute

Career Start Year 2001

Number of shared co-authors 8

Mariano J Alvarez

Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center

Career Start Year 2000

Number of shared co-authors 6

Dalia Barsyte-Lovejoy

University of Toronto, College St

Career Start Year 1999

Number of shared co-authors 3

Tero Aittokallio

Institute for Molecular Medicine Finland (FIMM), University of Helsinki

Career Start Year 1999

Number of shared co-authors 11

Stephan C Sch??rer

Institute for Data Science and Computing, University of Miami

Career Start Year 1998

Number of shared co-authors 9

Jason Moffat

University of Toronto

Career Start Year 1997

Number of shared co-authors 7

Michael C Bassik

Stanford University Medical Center

Career Start Year 1997

Number of shared co-authors 8

Yingyao Zhou

Genomics Institute of the Novartis Research Foundation

Career Start Year 1997

Number of shared co-authors 8

Jack Taunton

University of California san francisco

Career Start Year 1996

Number of shared co-authors 5

Jeremy S Caldwell

Sirna Therapeutics a former subsidiary of Merck & Co., Inc.

Career Start Year 1994

Number of shared co-authors 2

Krister Wennerberg

University of Copenhagen

Career Start Year 1994

Number of shared co-authors 9

Marc Ferrer

National Institutes of Health, National Center for Advancing Translational Sciences

Career Start Year 1992

Number of shared co-authors 5

David M Sabatini

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology

Career Start Year 1990

Number of shared co-authors 24

Stefan Knapp

Institute of Pharmaceutical Chemistry, Goethe University

Career Start Year 1983

Number of shared co-authors 5

row(s) 1 - 30 of 30

Stuart L Schreiber

Broad Institute

Co-authored papers 55

Paul A Clemons

Broad Institute

Co-authored papers 27

Vlado Dan????k

Broad Institute

Co-authored papers 14

Ramnik J Xavier

Broad Institute of MIT and Harvard

Co-authored papers 14

Bridget K Wagner

Co-authored papers 13

Todd R Golub

Broad Institute of MIT and Harvard

Co-authored papers 11

Joshua A Bittker

Co-authored papers 10

Jaime H Cheah

Johns Hopkins University School of Medicine

Co-authored papers 10

Matthew G Rees

Co-authored papers 8

Bernard Khor

Center for Translational Immunology, Benaroya Research Institute at Virginia Mason

Co-authored papers 6

Thomas B Sundberg

Cutaneous Biology Research Center

Co-authored papers 6

Pablo Tamayo

University of California San Diego

Co-authored papers 5

Nathanael S Gray

Harvard Medical School

Co-authored papers 5

Steven A Carr

Broad Institute of MIT and Harvard

Co-authored papers 5

William C Hahn

Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute

Co-authored papers 4

David E Root

Broad Institute of Harvard and MIT

Co-authored papers 4

Aviad Tsherniak

Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard

Co-authored papers 4

Anne E Carpenter

Broad Institute of MIT and Harvard

Co-authored papers 4

Brent R Stockwell

Columbia University

Co-authored papers 4

Isabel Latorre

Co-authored papers 4

Mark J Daly

Massachusetts General Hospital

Co-authored papers 4

Stefan Kubicek

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences

Co-authored papers 4

Jesse S Boehm

Broad Institute of Harvard and MIT

Co-authored papers 4

Finny G Kuruvilla

Co-authored papers 4

Levi A Garraway

Broad Institute of Harvard and MIT

Co-authored papers 3

Rajiv Narayan

Co-authored papers 3

Ted Liefeld

Moores Cancer Center, University of California San Diego

Co-authored papers 3

Benjamin Alexander

Co-authored papers 3

Barbara A Weir

Janssen Research and Development LLC

Co-authored papers 3

Joshua Gould

Co-authored papers 3

1 - 30

Author Details

Column Actions

Recommended Authors

Collaborators