Author details

Full Name

Kristin K Brown

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37216554	The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis.		2023
35216681	YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth.	Developmental Cell	2022
35851845	Glutamine addiction promotes glucose oxidation in triple-negative breast cancer.	Oncogene	2022
34862195	Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death.	Cancer Discov	2022
34582060	AMPK CA(R)Sts a new light on amino acid sensing.	EMBO Journal	2021
34285415	The PROTACtable genome.	Nat Rev Drug Discov	2021
33436370	Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia.	Cancer Discov	2021
30655532	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.	Nat Commun	2019
29776993	Tumor immune evasion arises through loss of TNF sensitivity.	Sci Immunol	2018
30108951	Approaches to target tractability assessment - a practical perspective.	MedChemComm	2018
30348863	Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.	EMBO Journal	2018
30138551	Biocatalytic Synthesis of Chiral N-Functionalized Amino Acids.	Angewandte Chemie - International Edition	2018
28255083	Adaptive Reprogramming of Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer.	Cancer Discovery	2017
27588899	Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.	Proc Natl Acad Sci U S A	2016
27428308	Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.	Nature Cell Biology	2016
26027929	MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.	Cell Rep	2015
25750731	The phosphoinositide 3-kinase pathway and therapy resistance in cancer.	F1000Prime Reports	2015
25086508	A human fatty acid synthase inhibitor binds Î²-ketoacyl reductase in the keto-substrate site.	Nature Chemical Biology	2014
24388745	S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury.	Cell Rep	2014
22722202	Sequence analysis of mutations and translocations across breast cancer subtypes.	Nature	2012
22975325	PKD controls Î±vÎ²3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5.	Developmental Cell	2012
21704127	Biological targets of isothiocyanates.		2011
21524095	A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of Î±HG.	Biochemistry	2011
20420387	Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase.	Journal of Medicinal Chemistry	2010
20686482	Type IIA topoisomerase inhibition by a new class of antibacterial agents.	Nature	2010
20176019	Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin.	FEBS Letters	2010
20006500	Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines.	Bioorg Med Chem Lett	2010
20005102	2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles.	Bioorg Med Chem Lett	2010
19776019	Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.	Journal of Biological Chemistry	2009
19381595	Proteomic detection of oxidized and reduced thiol proteins in cultured cells.	Methods in Molecular Biology	2009
18789312	The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation.	Biochemical Pharmacology	2008
18662907	Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2.	Protein Science	2008
18501718	Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.	Free Radical Biology and Medicine	2008
18457946	Cradle-loop barrels and the concept of metafolds in protein classification by natural descent.	Current Opinion in Structural Biology	2008
18639976	Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL.	Cancer Letters	2008
18073108	A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels.	Structure	2007
17705509	Binding of TPX2 to Aurora A alters substrate and inhibitor interactions.	Biochemistry	2007
17965184	Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.	Protein Science	2007
16675268	Model structure of the prototypical non-fimbrial adhesin YadA of Yersinia enterocolitica.	Journal of Structural Biology	2006
17027498	Common evolutionary origin of swapped-hairpin and double-psi beta barrels.	Structure	2006
16818653	Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2.	Cancer Research	2006
15939023	AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels.	Structure	2005
15476560	Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs.	BMC Evol Biol	2004
12576022	Bioinformatic analysis of ClpS, a protein module involved in prokaryotic and eukaryotic protein degradation.	Journal of Structural Biology	2003
12021456	Fold recognition without folds.	Protein Sci	2002
11964185	Characterization of Streptococcus pneumoniae thymidylate kinase: steady-state kinetics of the forward reaction and isothermal titration calorimetry.	Biochemical Journal	2002
11157938	Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis.	J Bacteriol	2001
11835483	Fold recognition from sequence comparisons.	Proteins	2001
11418856	Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebrates.	Nature	2001
11110912	Evolution of two-component signal transduction.	Mol Biol Evol	2000